81–90 of 122 posts
(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition…
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it's a veritable fuck-ton. the usual modern dose is 325mg.
The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.
You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID).
I've personally never seen it given more than 325mg daily.
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>But not daily. I probably take it once per week on average. My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was. A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to…
Add me to the anecdotal evidence there. A regular dose of ibuprofen and I can't eat and I throw up blood for a day..
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you know what they say, ten aspirin tablets a-day keeps the emergency room busy.
Even a small amount of Asprin, if taken regularly, will mess up your stomach in my experience! I guess not everyone is sensitive to it, but for me I've avoided Asprin (and Ibuprofen, another NSAID drug) for years because of this.
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A friend of mine swears that the reason acetaminophen is added to opioids (like hydrocodone) is so that you cant abuse the opioid without being poisoned by the acetaminophen. If true, it's alarming that the way to "prevent abuse" is to poison the patient.
That is completely correct. It also has synergistic effects as a pain reliever, but it's mainly there to deter abuse. Of course, addicts have found ways to extract the opiates from the adulterants, so it's not even effective.
Adding it for synergism makes sense and is what I was taught in medical school. I doubt they add it to deter abusers, but I could be wrong...
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The maximum daily dose is usually around 4g. 325mg is probably the dose in one tablet.
Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.
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I do the same as well. It pretty much has changed my life. The only thing I have noticed is that it seems not work well for females (my wife is annoyed about that). Also strangely my blood sugar has been above normal lately which is strange because I don't eat a carb heavy diet and I have never had blood sugar problems. Last time it was checked it was ~105 mg/dl or so (and I was fasted of course). I have had some the…
What's your theory about the blood sugar? I have the same issue. Hovers around 100 when not eating. What's weird is it drops to 85 within 20 minutes after eating a meal. I'm not sure what that could mean.
[1] https://www.uspreventiveservicestaskforce.org/Page/Document/... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/
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>But not daily. I probably take it once per week on average. My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was. A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to…
Add me to the anecdotal evidence there. A regular dose of ibuprofen and I can't eat and I throw up blood for a day..
Earlier quoted context omitted.
Doctor here: very rarely does any prescribe anything more than 325mg daily. Most people get 81mg daily. 325mg is considered high dose. You are correct that it can be written for more, but the only indication you would prescribe a higher dose is as a pain or fever reducer, and we have more effective NSAIDs for that. Or tylenol (?NSAID). I've personally never seen it given more than 325mg daily.
What do you mean by (?NSAID) after tylenol?