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Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

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71–80 of 106 posts

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#71

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

> Could ASD be helped by reducing salt? or increasing salt? Personal story here (N=1, not claiming anything other than that). My dad is clearly ASD, and has battled high blood pressure for as long as I can remember. He's now suffering the consequences of 40 years of absolute salt avoidance. 1) I never saw and reduction in the ASD over the past 40 years, 2) lack of salt never changed his blood pressure, and 3) now he'…

My prediction: in fifty years, "low-salt" will have gone the way of "low-fat." Too late for millions of people whose health was injured and lives shortened by these terrible fads.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#72
post #71

Earlier quoted context omitted.

> Could ASD be helped by reducing salt? or increasing salt? Personal story here (N=1, not claiming anything other than that). My dad is clearly ASD, and has battled high blood pressure for as long as I can remember. He's now suffering the consequences of 40 years of absolute salt avoidance. 1) I never saw and reduction in the ASD over the past 40 years, 2) lack of salt never changed his blood pressure, and 3) now he'…

My prediction: in fifty years, "low-salt" will have gone the way of "low-fat." Too late for millions of people whose health was injured and lives shortened by these terrible fads.

Improbable since reducing added fats is still as good advice today as it was 5 decades ago.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#73
post #31

Earlier quoted context omitted.

ASD diagnoses have skyrocketed in the past few decades (years?) with no clear cause. I'm just old enough to remember a childhood without cell phones - we didn't have a computer in my house until middle school but we were lower income than most of my friends - and people are definitely inside more and outside less than they were when I was 8 or 9 years old. It seems like a plausible theory.

When left handedness was seen as a disorder and students who used their left hand were beaten, rates of this disorder were a few percent. When the idea of left handedness became mainstream, rates skyrocketed and we know the base rate is about 10%. Homosexuality was considered a disorder in the DSM until 1974. Self-reported rates of homosexuality have skyrocketed since then. Most likely explanation is that the true ba…

I wrote a response that argues against your hypothesis, and then I realized ... "do I really know what I'm saying? Or are these my preconceptions and biases?"

> and we know the base rate is about 10%.

Sinister.

I think it would be cool to be left-handed in a country where the language is written from right to left.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#74
post #71

Earlier quoted context omitted.

My prediction: in fifty years, "low-salt" will have gone the way of "low-fat." Too late for millions of people whose health was injured and lives shortened by these terrible fads.

Improbable since reducing added fats is still as good advice today as it was 5 decades ago.

Exactly right. Reducing dietary fats is "as good" advice as it was or ever will be.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#75

Earlier quoted context omitted.

> Could ASD be helped by reducing salt? or increasing salt? Personal story here (N=1, not claiming anything other than that). My dad is clearly ASD, and has battled high blood pressure for as long as I can remember. He's now suffering the consequences of 40 years of absolute salt avoidance. 1) I never saw and reduction in the ASD over the past 40 years, 2) lack of salt never changed his blood pressure, and 3) now he'…

Avoiding table salt thoroughly could potentially lead to iodine deficiency. It was somewhat common in the past so most table salt over the past century has had iodine added to it to avoid this, but it's cropping back up a bit as people avoid salt or prefer to use "natural rock salts" common in fine cuisine, which are not reinforced with iodine.

Iodine is in a lot of foods.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#76
post #31
post #25

Earlier quoted context omitted.

Could you elaborate on what you mean by "novel social conditions"?

ASD diagnoses have skyrocketed in the past few decades (years?) with no clear cause. I'm just old enough to remember a childhood without cell phones - we didn't have a computer in my house until middle school but we were lower income than most of my friends - and people are definitely inside more and outside less than they were when I was 8 or 9 years old. It seems like a plausible theory.

Correlation, as the saying goes, does not prove causation.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#77
post #30

That’s a fascinating introduction - they are concerned that dual (!) name of the molecule might be hiding all of its functions! It looks like naming thing is not just a problem for programmers.

When I was diagnosed with a neurological condition that was having mostly physical symptoms, the first-line defense was antidepressants. So-named because they were developed to relieve depression, but really what they do is inhibit absorption of serotonin and/or norepinephrine leaving more free in the body to act on myriad different bodily functions. In my case, it actually caused serious digestion issues. It really…

Was an anti- inflammatory diet for me

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#78
post #7

Earlier quoted context omitted.

One thing I always found interesting is that inducing a fever in autistic people, in some of them it will reduce the severity of their autistic characteristics.

The one that weirds me out is that sleep deprivation can quite rapidly reduce depression, if only temporarily: https://www.pennmedicine.org/news/news-releases/2017/septemb...

I did this in my late young years. It worked. Got started reading into “polyphasic sleeping “ , we were deluded for thinking it could be a long term healthy schedule but it definitely seems to have given me a mood reset and cured my insomnia.

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#79
post #7

Doing quick search, there is also interactions between Vasopressin and salt and blood pressure. Could ASD be helped by reducing salt? or increasing salt? I'm not knowledgeable enough to untangle all of the studies where these terms are also used, which I guess is part of the problem this paper is pointing out, that the terminology/naming is confusing. Is this saying if you have blood pressure problems you might also…

One thing I always found interesting is that inducing a fever in autistic people, in some of them it will reduce the severity of their autistic characteristics.

Some of them also respond to anti biotics

Re: Vasopressin deficiency: driver of social impairment and fluid imbalance in ASD? [pdf]

#80
I was a guinea pig in a clinical trial for a drug that was meant to help with social symptoms of autism, the mechanism of which had something to with vasopressin (I don't know the details): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260643/ .

It didn't do anything for me and the study got cancelled after I'd been taking the drug for some months.

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