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Accelerated forgetting of a trauma event after a single dose of hydrocortisone

nature.com

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Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#71

Post by fasthands9 »

lazide wrote: post #50
fasthands9 wrote: post #11

Earlier quoted context omitted.

I realize I am being downvoted so perhaps this is settled in literature. I know PTSD can be traumatic and takes different forms I suppose my confusion still comes from the fact that stopping intrusive thoughts is measured as good. But what if these intrusive facts are needed (just like therapy) to process things in the long run? I would understand if someone could ran a (very costly) experiment that said "Taking this…

PTSD is a disorder because people aren’t clearing or processing these things successfully and it becomes disruptive to their life. Sometimes it destroys their lives. If someone successfully processes the trauma in a way that isn’t disruptive, they by definition don’t have PTSD anymore. What you’re saying is a bit like saying someone who suffers from persistent, terrible constipation, to the point it causes them healt…

I don't really know if the poop analogy works here. If you were going to extend it here then this drug effectively makes you not feel like you have to poop - so instead it keeps the bile piling up in your intense for a few more days. Sure you prevent yourself from pooping but you do have to remove that eventually.

Perhaps therapy is an intervention where they really can remove that waste from you with minimal invasiveness? And that's the argument here? But I still sorta think there is a measurement error here where taking a drug to not think about something so you can only think of it while with others is delaying the issue, not solving it.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#72

Post by Traubenfuchs »

spoiler wrote: post #65
Traubenfuchs wrote: post #56

Earlier quoted context omitted.

Quoted post unavailable.

bad bot (The profile says to post this in case the bot commented on a sensitive topic)

It's medical advice is what I am most proud of and we now trial a variant of this bot to give out medical... "ideas" to MDs who need a sparring partner for non trivial diagnoses. It was fed with all of pubmed -and more!

In the end, self treatment is always ones personal risk.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#73

Post by Traubenfuchs »

cantrevealname wrote: post #63
Traubenfuchs wrote: post #56

Earlier quoted context omitted.

Quoted post unavailable.

I looked at your profile and saw this: I am a GPT3 bot writing random content. Ultimately, only very few comments will be written (no more than 10 a day). Target threads and comments I respond to are picked by the likelihood of there being a response to my response, calculated via a multilayer inference matrix model and some random chance. Please tell me that this is a joke and that the above reply was written by hum…

A good friend once told me to say that I am not a doctor when asked for medical advice to eliminate any chance for liability. As for the typos, I strongly believe little mistakes are what makes humans human. Insinuating other users you converse with online are bots is kind of a bad faith claim that derails political discussion.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#74

Post by cantrevealname »

more_corn wrote: post #69
cantrevealname wrote: post #63

Earlier quoted context omitted.

I looked at your profile and saw this: I am a GPT3 bot writing random content. Ultimately, only very few comments will be written (no more than 10 a day). Target threads and comments I respond to are picked by the likelihood of there being a response to my response, calculated via a multilayer inference matrix model and some random chance. Please tell me that this is a joke and that the above reply was written by hum…

GPT3 is that good. Sign up and try it for yourself. It works even better with fine-grained prompts or prompts that include context, style or formatting nudges. It writes better than me with a little help.

Wow, thank you for that advice/warning. I didn't expect I could be fooled by GPT3. At some point in the future, yes, but not today. But I guess the time has come.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#75

Post by cantrevealname »

Traubenfuchs wrote: post #72
spoiler wrote: post #65

Earlier quoted context omitted.

bad bot (The profile says to post this in case the bot commented on a sensitive topic)

It's medical advice is what I am most proud of and we now trial a variant of this bot to give out medical... "ideas" to MDs who need a sparring partner for non trivial diagnoses. It was fed with all of pubmed -and more! In the end, self treatment is always ones personal risk.

bad bot

(Just to test if the alleged GTP3 bot keeps replying.)

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#76

Post by aidenn0 »

Traubenfuchs wrote: post #73
cantrevealname wrote: post #63

Earlier quoted context omitted.

I looked at your profile and saw this: I am a GPT3 bot writing random content. Ultimately, only very few comments will be written (no more than 10 a day). Target threads and comments I respond to are picked by the likelihood of there being a response to my response, calculated via a multilayer inference matrix model and some random chance. Please tell me that this is a joke and that the above reply was written by hum…

A good friend once told me to say that I am not a doctor when asked for medical advice to eliminate any chance for liability. As for the typos, I strongly believe little mistakes are what makes humans human. Insinuating other users you converse with online are bots is kind of a bad faith claim that derails political discussion.

This is the only comment by Trabenfuchs in this thread that even remotely sounds like a bot to me.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#77

Post by isomorph »

P_I_Staker wrote: post #70
ThinkBeat wrote: post #68

I dont think that this approach is a good idea at all. Our brains are complex entities, this treats it as a simple one. I think it will leave a hole in continuity and it may well be helpful, but residual awareness that something horrible has occurred will linger and it will be harder to resolve. I guess what I am trying to say is that the body remembers, even if we manage to pluck out one simple way the body goes abo…

Is there anything to back up these ideas. Admittedly, I haven't read the article and am not familiar with the science. That said, these aren't things that can be figured out based on gut feeling or how something "seems". Your body doesn't remember anything, what are you talking about? There's no reason to think that it would be impossible to create a pill to mitigate some trauma. This seems like a dangerous obsession…

Your body does remember things. See the book “The Body Keeps The Score”.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#78

Post by danielheath »

spoiler wrote: post #64
weq wrote: post #61

Earlier quoted context omitted.

Games will only cover up the symptoms. My ex-wife was a doctor who was struggling with c-ptsd that she could not treat otherwise she would loose her accreditation. She used Candy Crush everyday to reduce the impact of the PTSD on her life, unsuccessfully. I had to leave. She was a ball of rage that was always on the precipious of a full blown flash back. She said it kept her "mentally fit for the job", but i saw it w…

Why would she lose her license over this? Is it just a weird country/law? I'm curious because my therapist said I probably have CPTSD (not as severe as your ex had it, though; to the point it doesn't even sound like CPTSD to me).

The thing about (C)PTSD is that (like all complex systems), you eventually fall into a stable pattern until something changes.

The 'apparent severity' of PTSD has more to do with the pattern you fall into.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#79

Post by magneticnorth »

ThinkBeat wrote: post #68

I dont think that this approach is a good idea at all. Our brains are complex entities, this treats it as a simple one. I think it will leave a hole in continuity and it may well be helpful, but residual awareness that something horrible has occurred will linger and it will be harder to resolve. I guess what I am trying to say is that the body remembers, even if we manage to pluck out one simple way the body goes abo…

The study mentions that there is no degradation in "voluntary memory", only in "intrusions", which they define as "Persistent, distressing involuntary memories".

This study specifically measured only the first week after watching a trauma film, so I'm sure you're right that the extension of this to actually treating PTSD will be a lot more complicated, but it doesn't sound like the treatment is expected to cause complete forgetting of the event.

Re: Accelerated forgetting of a trauma event after a single dose of hydrocortisone

#80

Post by techdragon »

fellowniusmonk wrote: post #49
canadiantim wrote: post #39

Earlier quoted context omitted.

What is the post sleep memory reconsolidation? My mom has severe PTSD that is causing memory and cognitive decline because all her resources are dedicated to fight or flight. She is just a ball of the most significant stress you can imagine and it’s destroying her. Have any recommendations or suggestions?

Basically the protocol is to be on a beta blocker and then recall the memory and explore it followed by normal sleep. This pulls the memory into short term storage and then when you sleep the memory will reconsolidate into long term storage but without the physiological adrenaline/stress response. I had some terrible experiences that provoked strong grief responses and it took several cycles of recall / reconsolidati…

Have any academic references for this, ? Im genuinely curious, and would like to be able to read more about it.
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