Diabetes in mice cured rapidly using human stem cell strategy • Hacker News Board

Re: Diabetes in mice cured rapidly using human stem cell strategy

#71

Post by jfritsch1984 » Sun, Mar 15, 2020, 4:25 PM UTC

flexblue wrote: post #65

jfritsch1984 wrote: post #64

Earlier quoted context omitted.

Who says that B12 supplementation works less good than eating meat? The last studies I read on supplementation all showed good results. Better results than among omnivorous people.

Vitamin B12 supplements require very high doses due to poor bio-availability. You have to ask yourself, could this be a healthy diet when you effectively need a pharmacy to maintain it? What else is your body missing out on that we might not be aware of? That's why I say a plant-based diet is science experiment with no plausible basis in evolutionary history. I'm not saying it's bad per se, I'm saying we don't actual…

Also: Check how many people on SAD are fiber deficient.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#72

Post by bsanr2 » Sun, Mar 15, 2020, 8:45 PM UTC

flexblue wrote: post #22

pengaru wrote: post #21

Earlier quoted context omitted.

It is true, the produce department has some of the cheapest food in the store. How much is a bundle of bananas? That's a week's breakfast. Unless you only buy organic, then you might go broke while hungry.

Bananas by themselves are not healthy food, they're very high in sugar and have little else to offer. Produce may look cheap, but if you add up the macros (and also some of the micros), it doesn't look cheap at all.

Also, the time cost of preparation.

I don't think there's a common understanding of how much time working class people have to spend on work. It's frequently on the order of 50-60 hours across more than one job, plus the attendant transit and pre-work chores. Your job doesn't provide you with cheap, healthy food on-site. You frequently can't eat on the way to or from work, per transit rules or enhanced police presence on your route. Lunch breaks are a strict 30 minutes, and being late can get you fired (hope whatever you're eating doesn't have too much fiber). You may have to go out of your way to shop, if you live in a food desert, and apartment fridges preclude buying in bulk. Oh, and for a racial angle, produce in cities (and, not uncommonly, in majority-minority suburbs) costs more than in white suburbs and rural areas.

We have so many UX experts on here, is it really that difficult to think of this problem as an experiential narrative instead of an engineering problem that can be solved by tweaking a few variables?

Re: Diabetes in mice cured rapidly using human stem cell strategy

#73

Post by lolc » Sun, Mar 15, 2020, 10:21 PM UTC

TylerE wrote: post #40

lolc wrote: post #26

> A common problem when you’re trying to transform a human stem cell into an insulin-producing beta cell — or a neuron or a heart cell —is that you also produce other cells that you don’t want In my world this is called cancer. So yeah interesting how they're actually able to tell cells how to grow. But you don't want liver cells mixed into your pancreas, do you? > But if a quarter of the cells you make are actually…

No, that's just mutation, or something. It isn't cancer unless it continuously reproduces.

> No, that's just mutation, or something.

Mutation is how one gets cancer. If only they knew how to detect mutated cells! They might just cure cancer!

Re: Diabetes in mice cured rapidly using human stem cell strategy

#74

Post by ficklepickle » Mon, Mar 16, 2020, 2:25 AM UTC

jfritsch1984 wrote: post #53

pengaru wrote: post #19

Earlier quoted context omitted.

> When you can buy twinkies and pork chops you're not actually poor. When you are really poor you eat rice and beans and some vegetables you grow for yourself. And then you don't have diabetes typically. The EBT program here in the US completely distorts the situation. My local grocery store serves a very poor community, most of the customers pay with EBT. I get to see what kind of things these folks buy, it's idioti…

As I said: These people should be educated and motivated. They have to learn about the consequences of these decisions. Only if that does not work I would restrict EBT to healthier foods. On a personal note: I agree with you. It‘s hilarious what people buy even when they are on a tight budget.

Is it hilarious? Is the misfortune of others humorous?

Perhaps it's the people with poor impulse control and lack of education that end up economically poor. Maybe they never learned better.

Taking pleasure from those less fortunate than yourself is a trick of the ego. It makes you feel better about yourself by labeling someone else inferior. It comes from a place of insecurity about one's own worth.

By simplifying the problem to a group of people simply being inferior, you miss all the nuance, the complex system of factors that created the result.

It's much easier to dehumanize. But if we don't counter these primitive tribal urges, we are bound to repeat the tragedies of history.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#75

Post by chx » Mon, Mar 16, 2020, 11:14 AM UTC

hombre_fatal wrote: post #43

chx wrote: post #42

Earlier quoted context omitted.

https://www.medicalnewstoday.com/articles/321864 > New research suggests that intermittent fasting may raise insulin levels, damage pancreatic cells, and increase the amount of abdominal fat. > Specifically, the new study — led by Ana Cláudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil — suggests that intermittent fasting may impair the normal activity of the pancreas and the production of i…

Dr Nicola Guess, Lecturer in Nutritional Sciences at King’s College London, responding to that study: > Firstly, it’s important to bear in mind there are important differences between rodents and humans – particularly with regard to diet. For example, a high fat diet causes insulin resistance in rats but it does not appear to in humans. > The exact method is unclear from the abstract, but if the rats were fasted for…

This is hard to put into the right words especially in a short way but

The entire "what should I eat" field is so full of bad science that I disbelieve everything. There is so much money to made here it's astonishing and it makes everyone's motives questionable.

I believe in a somewhat closer-to-the-nature approach without going stir crazy.

Moving from very processed foods to their less processed versions felt like a good move. I am playing this by the ear because as our conversation shows there is a study to counter every other study.

I personally believe that general food advice can't exist because surely our genetics play a role in how our body reacts to different foods -- foodstuff itself is very complex chemically, biologically.

In short, intermittent fasting is unnatural and

Re: Diabetes in mice cured rapidly using human stem cell strategy

#76

Post by grep_name » Mon, Mar 16, 2020, 5:01 PM UTC

geden wrote: post #57

Closed loop insulin delivery systems functionally “cure” t1 diabetics and are here today. Have implemented for a t1 friend. Has transformed his long term outlook. https://loopkit.github.io/loopdocs/ Relies on currently quite expensive hardware (continuous glucose monitors / insulin pump / iPhone / Bluetooth to radio device) but that could all be combined into 2 cheap devices easily. Regulation and inertia just seems…

> Closed loop insulin delivery systems functionally “cure” t1 diabetics and are here today.

You should be careful using that word around type 1 diabetics. Incidentally I was on medtronic's loop system for about a year and a half, but you couldn't pay me enough to go back to it. Not saying it doesn't work for some people (often people with very stable hormonal systems who don't have large variations in their physical activity levels), but even in the best case calling it a cure is rough claim to hear being familiar with the reality of dealing with these things. I'm glad that it was a success for your friend though.