Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

Post reply on HN
Print view View original

601–610 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#601

Post by potato3732842 »

zarzavat wrote: post #504
Llamamoe wrote: post #453

Earlier quoted context omitted.

> because most people can eat just fine even if not really hungry. I literally cannot imagine how this is possible. Don't you feel full? Doesn't your body start refusing to swallow? Doesn't the food turn tasteless and start making you nauseous? 100-200kcal over your BMR, sure, but beyond that?

Hunger and satiation are two different neural pathways. Hunger is low blood sugar. Satiation is stretching of the stomach. You can still eat even with normal blood sugar if your stomach isn't full.

Which is a large part of why weight loss diet advice usually included a bunch of stuff about stuffing your face with iceberg lettuce and other high volume low calorie foods. It makes you feel satiated sooner.

Re: Ozempic shows anti-aging effects in trial

#602

Post by lm28469 »

ben_w wrote: post #545
sjw987 wrote: post #511

Earlier quoted context omitted.

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

> If people can't be arsed doing that and we give easy shortcuts for everything in life, what's the point in being alive? Embrace the shortcuts. Life's too short not to. What's that Plato quote about writing? If men learn this, it will implant forgetfulness in their souls. They will cease to exercise memory because they rely on that which is written, calling things to remembrance no longer from within themselves, but…

The truth is that we designed a system in which a majority of people cannot thrive and in which a lot of people end up developing problems like obesity or being labeled as ADHD. Now the same system designed a cure, one that you have to pay for and take for years if not for life, just so that you can rewire your perfectly normal brain to fit in the very imperfect mold of what the system needs

Taking antidepressant won't fix your depressing environment

Taking sleeping pills won't fix your sleep depriving routine

Taking ozempic won't fix your stressful job that materialized into an compulsive eating

The extreme vast majority of people have perfectly normal bodies/hormones/&c. but are evolving in unhealthy environments, you're merely fixing the last link of the chain, if you stop there, like a lot of people do when they're being advertised magic pills, you're setting up yourself for failure. The fact that all of these lifestyle disease increased 100 folds in the last 50 years should be a clear sign that the problem isn't the human body/brain, but whatever the fuck we're collectively agreeing to take part in.

Also the fact that plato was wrong about one piece of progress 2000 years ago doesn't mean every new thing since then was a net positive for humanity. You could have used the same argument for decades about asbestos, leaded paint, leaded gas, freon, &c. and yet here we are...

Re: Ozempic shows anti-aging effects in trial

#603

Post by jghn »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> if it would improve the evolutionary fitness of the majority of people

The issue with this logic is that evolution tends to find local, not global, maxima

Re: Ozempic shows anti-aging effects in trial

#604

Post by radiofreeeuropa »

skeezyboy wrote: post #513
radiofreeeuropa wrote: post #58

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

> It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. um, go out and exercise? compared to your ancestors from a century ago, you live a relative life of luxury. THIS IS WHY YOU ARE FAT. Too much food in, not enough burning calories. So simple. Im sure there are people who are clinically fat, broken metabolism, but there are tens of millions of obese i…

Yep, overeating (and, to some degree, not enough moving around) is the reason. True.

But “just personally do better” doesn’t work very well when applied as a medical intervention (they have tried, and checked, over and over, a hundred different ways), even with lots of follow-up and monitoring, and it also doesn’t appear to be how other countries manage to be skinnier than the US. Between those two things, it really doesn’t look like a viable way to solve the obesity crisis—it doesn’t work when we try it, and it doesn’t seem to be what’s working anywhere else.

Re: Ozempic shows anti-aging effects in trial

#605

Post by sumeno »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

If not having cancer is so great why don't our bodies just not make cancer cells?

Weight loss aids are given far more scrutiny because people wrongly view it as a moral failing

Re: Ozempic shows anti-aging effects in trial

#606

Post by jonathan_h »

xienze wrote: post #538
guerrilla wrote: post #527

Earlier quoted context omitted.

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "disciplin…

> don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc. Not to be _too_ rude here, but clearly you missed the mark on at least one of those things. If you're burning more energy than you're consuming, it's impossible to not lose weight. Maybe you underestimated how many calories you were consuming, overestimated how many calories you were burning, didn't do it often en…

The missing piece is that the body does not burn a constant amount of energy, and often the body's response to calorie restriction is to reduce the amount of energy used. [1]

Play the weight-loss game with your body, and you'll find the goalposts get moved.

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9036397/

Re: Ozempic shows anti-aging effects in trial

#607

Post by alistairSH »

IncreasePosts wrote: post #396
anovikov wrote: post #389

I know why people hate Ozempic. It is because it devaluates struggle and voids moral superiority of those who did keep themselves from becoming obese by self-restriction before: now these people feel like fools because all of a sudden, everyone is becoming slim, and the advantage of being slim disappears. They naturally question how is it fair. Well, life's not fair.

I hate ozempic because I have no reason to be prescribed it and if it has these anti aging effects or improves self control with other vices, I'm missing out and the ex-fatties will all live longer than me

As noted in the article, and in some other posts here, the effects are seen in patients who are overweight or have diabetes (and thus generally qualify for Ozempic). None of the studies I've skimmed indicate Ozempic is directly slowing aging or whatever else - it's all a knock-on effect from weight loss and calorie restriction.

IE, if you can self-restrict, you get the same benefits. You just have to deal with that little voice in your head that keeps yelling "feed me a pizza!!!" (at least that's what mine usually says).

But, yeah, I hear ya, I wouldn't mind doing a few months at a low dose to get my body fat % back down near 10%, but I'm nowhere near "needing" the drug and the only way I'm getting a prescription is probably through a shady online doctor.

Re: Ozempic shows anti-aging effects in trial

#609

Post by SamPatt »

skeezyboy wrote: post #510
otikik wrote: post #454

Earlier quoted context omitted.

There is another way to look at it. People who don't experience difficulties moderating their diet and could flounder their "self discipline" are now on a level field with people who did have difficulties with their diet. So they feel threatened by it. Another example of a world in which people are not challenged to grow as people; instead of being happy that more people can get healthy they dismiss the medical advan…

go out and get some exercise, run around, why is this never an option?

Of course it is an option - I lost 100 lbs this way, and kept it off more than 5 yeads. As you know, that's very, very hard.

But I think these drugs are awesome. I have family members who are obese and don't seem to have whatever I have that allowed me to lose weight the old-fashioned way. I hope they'll be able to lose weight safety with the drugs.

Re: Ozempic shows anti-aging effects in trial

#610

Post by esperent »

radu_floricica wrote: post #498
simmerup wrote: post #433

Earlier quoted context omitted.

Statins change some peoples personalities https://www.bbc.co.uk/future/article/20200108-the-medication...

I don't think we really need to worry about rare and very rare side-effects. Or if we do, it'd be fair to also start worrying about all of them equally, but that would mean not taking any drugs ever.

> that would mean not taking any drugs ever.

It would mean quantifying the risks of side effects versus the risks of not taking the drugs, which we should be doing anyway.

Post reply on HN