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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#31

Post by throwforfeds »

hollerith wrote: post #28
some_random wrote: post #24

Earlier quoted context omitted.

I think that's a completely reasonable concern to have, it doesn't seem to be the case wrt obesity but for the myriad of other potential effects it's important to keep in mind.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

I've had a few friends on it. They definitely lost weight, but the GI issues were too much and when they went off of it they gained it all back.

Re: Ozempic shows anti-aging effects in trial

#32

Post by dexwiz »

NoMoreNicksLeft wrote: post #27
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

>My opinion is to wait long enough to validate there are no long term harms, What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

Not OP but 10-15 years for most drugs. Took about a decade for the general consensus around Oxy to change.

Re: Ozempic shows anti-aging effects in trial

#33

Post by Barrin92 »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

>seemingly need to believe that it's some kind of Faustian bargain

I mean, that's because that's literally what they need to believe. A majority of people has been brought up on an incredibly moralized account of human behavior, and if it turns out you can just pour some GLP-1 drugs into the drinking water and basically fix a whole bunch of issues it will become obvious that a therapeutic framing is the appropriate way to look at these things.

For people who live in a world of vices and sinners who have to swear off the devil, this throws a pretty big wrench into the whole story, it's much more than just a drug.

Re: Ozempic shows anti-aging effects in trial

#35

Post by 2OEH8eoCRo0 »

dexwiz wrote: post #32
NoMoreNicksLeft wrote: post #27

Earlier quoted context omitted.

>My opinion is to wait long enough to validate there are no long term harms, What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

Not OP but 10-15 years for most drugs. Took about a decade for the general consensus around Oxy to change.

Haven't these been out for a very long time, just not for weight loss?

A quick Wikipedia search shows Exenatide was FDA approved in 2005 for diabetes.

Re: Ozempic shows anti-aging effects in trial

#36

Post by radiofreeeuropa »

kjkjadksj wrote: post #26
pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

Any means of attaining weight loss at a similar rate will tend to do the same thing. Especially if you’re starting from quite-heavy, not just dropping 20lb or something.

Re: Ozempic shows anti-aging effects in trial

#37

Post by gryn »

NoMoreNicksLeft wrote: post #27
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

>My opinion is to wait long enough to validate there are no long term harms, What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

I'm a late adopter to most things.

my estimate would bigger than others and I would put it at 30-50years.

I take smoking as a cautionary tale, in the beginning it was pushed as not just a recreational thing but a healthy activity that bring benefits with papers published to sing praises about it. my parents were even nudged by their teachers/doctors/etc when they were young to try smoking.

now we all know that smoking is beyond bad and all that early "research" was just people paid off by big companies to promote it.

Re: Ozempic shows anti-aging effects in trial

#38

Post by alistairSH »

throwforfeds wrote: post #31
hollerith wrote: post #28

Earlier quoted context omitted.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

I've had a few friends on it. They definitely lost weight, but the GI issues were too much and when they went off of it they gained it all back.

I've read (anecdotes from people in the fitness/body-building space) that the default dosing could be too high for many people. And the side-effects seem to ramp up with the dose.

IE, if you're getting weight loss at 1/2 the default dose, you might want to stay there, even if your MD wants you to increase to the default.

[default uses loosely here - people build up from a low dose over the span of weeks/months]

And the weight gain is due to a lack of lifestyle change. The drug just numbs your appetite, so you don't eat as much. If you go off the drug and return to over-eating, yep, you gain the weight back.

I also suspect many people lose the weight too fast and go too far. "Ozempic butt" is a joke for a reason - people loose a bunch of fat, but the massive calorie deficit also means they aren't exercising (no energy, and they probably weren't before the drug either), so they've probably crashed their metabolism.

Re: Ozempic shows anti-aging effects in trial

#39

Post by Someone1234 »

thurn wrote: post #34

Are we close to having generic semaglutides e.g. available in India? Or locked into high prices for the foreseeable future?

Generic Semaglutide is already produced on a massive scale throughout the world. However, it is unlawful to import and sell and will remain so until 2032 in the USA.

In other markets, where it is under patent, it is significantly cheaper than the $500/month or more in the US currently. For example in the UK it is roughly $150/month USD privately (i.e. not through the NHS).

In China it will be out of patent within two years.

Re: Ozempic shows anti-aging effects in trial

#40

Post by readthenotes1 »

qgin wrote: post #18
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

There were even people who felt this way about anesthesia too. To survive in that era, they had to believe that suffering was somehow good for healing (or at least good spiritually) and talked about anesthesia as if it were cheating the natural god-given order.

Are you talking about MMother Teresa? She wasn't that long ago...
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