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Memory decline after menopause linked to loss of estrogen production in brain

news.northwestern.edu

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Re: Memory decline after menopause linked to loss of estrogen production in brain

#61

Post by analog8374 »

stevenhuang wrote: post #24
phoronixrly wrote: post #8

Earlier quoted context omitted.

Eh, have you seen any research on this or are you quoting own experience?

All of the claims above wrt memory reads quite mundane and adequately non assertive, but I'm a layperson. I do believe it's well established that memory is associative. It's why roses are associated with love, because of Valentine's Day. If you see roses or smell roses, you will recall memories of your loved ones maybe, especially if you have given them roses. Whether the decline in estrogen content of a room can be…

Most people are profoundly conformist in their opinions and very defensive towards the smallest contradiction. It's a conversation-killer. It's the cement that binds society. It is what it is.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#62

Post by grvdrm »

Scroll_Swe wrote: post #39
grvdrm wrote: post #29

Earlier quoted context omitted.

And for me - total stomach mess too.

For sure, beer is a great cure for constipation in that it causes liquid stools.

That and my god the odors! The interaction is so much worse in my 40s than it used to be.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#63

Post by shiandow »

gavinray wrote: post #48
ranger207 wrote: post #15

Earlier quoted context omitted.

Re #2, in the mtf trans experience high estrogen and low testosterone are correlated with low libido, with some individuals even temporarily stopping antiandrogen medications in order to get some back

Unfortunately, anti-androgens have myriad effects beyond basic T suppression. There are two primary drivers behind why anti-androgens would cause loss of libido beyond effect on T: 1) AA's cause androgen receptor blockade systemically. This blocks action at the AR that would be residual across systems from adrenal production. Most important for libido are the AR activity that occurs inside of neurons and astrocytes i…

It will depend exactly which anti androgen is used. I think you're describing the effects of cyproterone. Spironolactone has other side effects (a lot of them), while triptoreline targets the production of LH and FSH directly and seems to have fewer effects on other systems (though honestly it's a bit hard to tell)

Re: Memory decline after menopause linked to loss of estrogen production in brain

#64

Post by swat535 »

Aurornis wrote: post #36
gavinray wrote: post #11

Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation. Here are a few facts about estradiol that others might find surprising: 1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for ob…

Estrogen becomes a real problem for people experimenting with anabolic steroids or even taking some of the TRT regimens which go past replacement doses and into performance enhancing territory. Testosterone is converted into estradiol by aromatase, so people who boost their testosterone up to high levels get more estradiol as a result. As an aside: Aromatase is present in body fat, so higher body fat will produce mor…

Anything that increases Testosterone will increase E2 , you don't even need TRT!

For example I'm on HCG treatment due to Secondary Hypogonadism causing low Testosterone levels.

My urologist prescribed on a _moderate_ of HCG instead of TRT. I have to do regular blood checks every 3 months just to make sure all is in order.

The treatment was successful, as in my Testosterone and Free Testosterone returned to normal and all my side effects disappeared. My sperm count also doubled which was great.

However, even with a _moderate_ dose, it caused a spike in my Estradiol! Luckily, not enough that would require medication to counter that.

It's been 3+ years now. My recommendation to all men is to get checked, but don't self inject yourself with Testosterone without professional medical oversight.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#65

Post by phoronixrly »

analog8374 wrote: post #61
stevenhuang wrote: post #24

Earlier quoted context omitted.

All of the claims above wrt memory reads quite mundane and adequately non assertive, but I'm a layperson. I do believe it's well established that memory is associative. It's why roses are associated with love, because of Valentine's Day. If you see roses or smell roses, you will recall memories of your loved ones maybe, especially if you have given them roses. Whether the decline in estrogen content of a room can be…

Most people are profoundly conformist in their opinions and very defensive towards the smallest contradiction. It's a conversation-killer. It's the cement that binds society. It is what it is.

I am in fact agreeing with your opinion, however I refuse to accept it without any evidence. And I don't think asking for sources or expressing a contradicting opinion is a conversation killer.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#67

Post by CSSer »

Qem wrote: post #31
zulux wrote: post #16

Earlier quoted context omitted.

Men have significant estrogen: Men: roughly 10–40 pg/mL Women (not at ovulation): roughly 30–40 pg/mL At Ovulation, women spike. Hence, libido changes. If you know, you know.

Think you. I didn't know there was such overlap in the levels between both genders. Do men's levels also take a hit with age?

Those numbers are bullshit. The bottom of a grown woman’s cycle is around 100 pg/ml. I have no idea where they’re getting those numbers but I assure you they’re wrong, and even if they were remotely correct about E levels being close to one another at some point in the cycle the majority of the time they’re much farther apart.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#68

Post by joxdosba »

swat535 wrote: post #64
Aurornis wrote: post #36

Earlier quoted context omitted.

Estrogen becomes a real problem for people experimenting with anabolic steroids or even taking some of the TRT regimens which go past replacement doses and into performance enhancing territory. Testosterone is converted into estradiol by aromatase, so people who boost their testosterone up to high levels get more estradiol as a result. As an aside: Aromatase is present in body fat, so higher body fat will produce mor…

Anything that increases Testosterone will increase E2 , you don't even need TRT! For example I'm on HCG treatment due to Secondary Hypogonadism causing low Testosterone levels. My urologist prescribed on a _moderate_ of HCG instead of TRT. I have to do regular blood checks every 3 months just to make sure all is in order. The treatment was successful, as in my Testosterone and Free Testosterone returned to normal and…

For what it’s worth, hCG disproportionately affects E2 levels relative to how much it increases T levels due to increased aromatisation activity.

This is particularly visible in bodybuilders who add hcg on top of existing supraphysiological T levels. E2 shoots up, T levels stay pretty much flat.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#69

Post by e40 »

nerdsniper wrote: post #50
gavinray wrote: post #43

Earlier quoted context omitted.

This is anecdata, but as someone who has used exogenous testosterone for the past 10 years, I feel significantly better with low T + high E2 than high T + low E2. I've had E2 levels as high as the low end of female ovulatory range (see attached image at bottom) and felt fantastic, though personal response varies. I stopped using aromatase inhibitors after the first few years due to having a worse sense of wellbeing c…

Same here. My cis-male body and brain really does strongly prefer high E2 levels. Just below “growing breast tissue” seems to be the sweet spot. Testosterone / DHT levels matter much less. Raising E2 a bit basically cured lifelong suicidal ideation and major depressive disorder for me overnight. And it’s been working for 6 years now. Libido is still fine - my girlfriends are satisfied unless i’m having a very stressf…

Your libido sounds more than fine if you have multiple girlfriends.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#70

Post by zparky »

ranger207 wrote: post #15
gavinray wrote: post #11

Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation. Here are a few facts about estradiol that others might find surprising: 1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for ob…

Re #2, in the mtf trans experience high estrogen and low testosterone are correlated with low libido, with some individuals even temporarily stopping antiandrogen medications in order to get some back

libido is fixed with progesterone (which is commonly taken ~1-2 years into hrt) for better breast growth. anecdotally it makes you completely f*king feral
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