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Memory decline after menopause linked to loss of estrogen production in brain

news.northwestern.edu

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Re: Memory decline after menopause linked to loss of estrogen production in brain

#11

Post by gavinray »

Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women

I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation.

Here are a few facts about estradiol that others might find surprising:

1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for obesity and metabolic disorders. Example: SLU-PP-332

2. Libido in males is regulated by E2. Androgens like testosterone/DHT seem to be required to support the biology of erectile function, but for mental libido estrogen is the primary component.

3. Estradiol is synergistically anabolic with androgens. This is why cattle hormone implants contain a blend of Trenbolone and E2

Estrogen has so many supporting functions in brain, muscle, adipose tissue, and bone health...

Apologies for no citations and rough formatting but currently on a phone. Happy to provide citations when home

Re: Memory decline after menopause linked to loss of estrogen production in brain

#12

Post by throw8394jrjr »

jona-f wrote: post #5
thridmddi9e93 wrote: post #2

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Women live much longer and more comfortable lives. Men are more likely to die before alzheimer can even manifest.

Well, I went out to disprove your thesis, thinking we can easily look at countries where men live longer than women in another country. For example, women in the US have a lower life expectancy than men in Australia (go figure). Now women are less than 1.4 times more likely than men to get dementia in australia, but about 2 times more likely to get alzheimer in the US. So that kind of points in your direction, but th…

[flagged]

Re: Memory decline after menopause linked to loss of estrogen production in brain

#13

Post by throw8394jrjr »

phoronixrly wrote: post #6
thridmddi9e93 wrote: post #2

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Women live much longer and more comfortable lives. Men are more likely to die before alzheimer can even manifest.

Eh, are you citing sone peer-reviewed research or are you making stuff up?

It is just a bro science, sorry. Correlation and simple statistics is not real scientific method, and does not fit into modern research!

Re: Memory decline after menopause linked to loss of estrogen production in brain

#14

Post by throw8394jrjr »

mirabilis wrote: post #10
thridmddi9e93 wrote: post #2

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Women live much longer and more comfortable lives. Men are more likely to die before alzheimer can even manifest.

US life expectancy in 2024 for women was 81.4 years; for men, 76.5 [1]; “non-early” symptoms of Alzheimer's typically begin after 65 [2]. I don’t think that the life expectancy average offset of ~5 years is the main factor here. 1. https://www.cdc.gov/nchs/products/databriefs/db548.htm 2. https://www.mayoclinic.org/diseases-conditions/alzheimers-di...

It also said "comfortable lives".

Also compare retirement ages, years worked, income (hard mental work)... it is well known that alzhaimer is corellated with brain activity (like solving suduku puzzles). Watching tv all day is not very healthy for brain...

Re: Memory decline after menopause linked to loss of estrogen production in brain

#15

Post by ranger207 »

gavinray wrote: post #11

Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation. Here are a few facts about estradiol that others might find surprising: 1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for ob…

Re #2, in the mtf trans experience high estrogen and low testosterone are correlated with low libido, with some individuals even temporarily stopping antiandrogen medications in order to get some back

Re: Memory decline after menopause linked to loss of estrogen production in brain

#16

Post by zulux »

Qem wrote: post #7

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Scientists have long theorized that the loss of estrogen after menopause may reduce the brain’s natural protection against memory loss and neurodegeneration. The part that makes no sense for me is men ending with smaller rates of dementia, given they had much less est…

Men have significant estrogen:

Men: roughly 10–40 pg/mL Women (not at ovulation): roughly 30–40 pg/mL

At Ovulation, women spike. Hence, libido changes. If you know, you know.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#18

Post by Supernaut »

Qem wrote: post #7

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Scientists have long theorized that the loss of estrogen after menopause may reduce the brain’s natural protection against memory loss and neurodegeneration. The part that makes no sense for me is men ending with smaller rates of dementia, given they had much less est…

> baldness, and the downside of the condition for sexual attractiveness of its bearers

Just a guess, and I highly doubt there are any reliable statistics on this, but perhaps balding men are less likely to be tempted to abandon their family unit, thereby making it more likely that their children will thrive and carry on their genes?

I base this theory on my own experience, which is that I went completely bald in my early thirties and haven't had a second look from a woman ever since. Even if I were the sort to want to cheat on my wife, there wouldn't be any takers![0]

[0] I'm not claiming that bald men are necessarily sexually unattractive. I just know that it didn't work for me, looks-wise.

Re: Memory decline after menopause linked to loss of estrogen production in brain

#19

Post by toisanji »

gavinray wrote: post #11

Estrogen (specifically Estradiol, E2) is one of the most important systemic hormones in both men and women I've spent a significant amount of my free time for the last 15 years studying androgen physiology and self-experimentation. Here are a few facts about estradiol that others might find surprising: 1. E2 acts as a master metabolic/energy regulator in humans. ER-alpha and pan-ER agonists are being developed for ob…

Any remedies to reverse this?

Re: Memory decline after menopause linked to loss of estrogen production in brain

#20

Post by XorNot »

Supernaut wrote: post #18
Qem wrote: post #7

> Nearly two-thirds of Americans with Alzheimer’s disease (AD) are women, but the reasons why women are more vulnerable are still not fully understood. Scientists have long theorized that the loss of estrogen after menopause may reduce the brain’s natural protection against memory loss and neurodegeneration. The part that makes no sense for me is men ending with smaller rates of dementia, given they had much less est…

> baldness, and the downside of the condition for sexual attractiveness of its bearers Just a guess, and I highly doubt there are any reliable statistics on this, but perhaps balding men are less likely to be tempted to abandon their family unit, thereby making it more likely that their children will thrive and carry on their genes? I base this theory on my own experience, which is that I went completely bald in my e…

This seems like an odd conclusion to draw. I'm married with a full head of hair and I couldn't tell you whether or not any woman has ever been interested because I'm not paying attention nor am I trying to draw it.
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