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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#61

Post by kuschku »

a3w wrote: post #42
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

That's why it's recommended to combine a half dose of ibuprofen and a half dose of paracetamol at the same time. (Plus some vitamin C)

Together they have higher pain killung effects than each alone, and the side effects are reduced as they affect different body parts. And the vitamin C reduces the damage to the stomach lining.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#62

Post by anjel »

a3w wrote: post #42
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

Adding to this, its the margin between a therapeutic dose and a harmful dose is most relevant. That margin for aspirin is wide, the same effective vs toxic margin for paracematol is shockingly narrow. Furthermore, the "aspirin is rough on your stomach whereas Tylenol is gentle" turns out to be McNeil Marketing puffery.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#63

Post by moritzwarhier »

oliveiracwb wrote: post #52

I live in Brazil. We have broad access to non-steroidal anti-inflammatory drugs. Even the best-known medicines have unexpected and unknown adverse effects: in general and specifically in people with unexpected genetic, enzymatic, and protein variations. This has no solution. The medicine acts differently in each body, which is subtly diverse from the others. I see a lot of research criticizing any "old" general medic…

Interesting how you put metamizole at #1 for long-term treatment. As far as my experience goes, many doctors do the same in Germany. On the other hand, I've heard that the medication is banned in many other countries.

I guess the safest way is to take up the treatment in a hospital, to check for immediate bad reactions.

On the other hand, like with many medications, severe allergies and individual sensibilities causing side effects often don't show up often in the short term, but rather suddenly after many dose intakes.

So I'm back where I started. Not disagreeing with what you say. It seems like these non-steroidal pain relief medications are poorly understood regarding their interaction with the whole body though.

Many OTC medications and even some prescribed ones (especially psychiatric medications) suffer from a very poor understanding and apparent lack of effort in improving the understanding of their mechanisms of action.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#64

Post by VirusNewbie »

odyssey7 wrote: post #27
nine_k wrote: post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

The studies I saw had people taking a lot, it wasn’t looking at people taking 400mg once a week of their knee or shoulder got sore during the workout.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#65

Post by adaml_623 »

SoftTalker wrote: post #49
bitwize wrote: post #12

Earlier quoted context omitted.

The vaccine-autism smoking gun that Andrew Wakefield and RFK Jr. heroically tried to find has, so far, failed to turn up. But there was a study recently that showed that autism is correlated with the mother taking acetaminophen during pregnancy.

The general advice is to not take any medication during pregnancy without a physician’s advice. This includes all over the counter medicines.

Provide a reference please. Which country is that from?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#66

Post by privacyking »

e40 wrote: post #54
artvandelai wrote: post #50

Earlier quoted context omitted.

NSAIDs reduce inflammation. Since inflammation is part of healing, they can slow recovery, but they’re useful when inflammation itself is a problem.

paracetamol is not an NSAID.

True but one of the proposed mechanisms of action is on the same pathway as NSAIDs

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#67

Post by propter_hoc »

Rebellos wrote: post #45
propter_hoc wrote: post #13

[flagged]

Not denying that acetaminophen/paracetamol has a horrible therapeutic index, but there are reasons why it is still so widely used. Despite potential hepatoxicity, it is considered the safest pain relief drug (this emerging research notwithstanding) Ibuprofen is not better in every way. For instance ibuprofen, as well as other NSAIDs, is much less gentle on gastrointestinal tract and puts much more strain on kidneys.…

Your comment is fair; obviously I wrote a pretty flippant comment, but the message is largely useful for most people.

The fact is that (largely due to the incredible marketing of Johnson & Johnson's Tylenol brand in the US) way too many people think acetaminophen is "safe and effective" when it's actually both pretty unsafe and pretty ineffective. Most people just "pop a Tylenol" by default without realizing it's not much better than placebo.

Sure there are cases where people have unique risks and should avoid NSAIDs. But for the vast majority of the public, if they or their kid are dealing with a headache, fever, menstrual cramp, or other transient pain or fever, they should reach for ibuprofen (with a snack) over acetaminophen. It's not remotely a close call.

I'm frankly pleased that people are becoming more aware of this and I don't mind taking a couple correction comments for presenting the info in a superficial way.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#68

Post by bryanlarsen »

kuschku wrote: post #61
a3w wrote: post #42

Earlier quoted context omitted.

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

That's why it's recommended to combine a half dose of ibuprofen and a half dose of paracetamol at the same time. (Plus some vitamin C) Together they have higher pain killung effects than each alone, and the side effects are reduced as they affect different body parts. And the vitamin C reduces the damage to the stomach lining.

Or if you need stronger painkilling you can take a full dose of paracetomol and either ibuprofen or aspirin. OTOH aspirin and ibuprofen use the same pathways so combining a full dose of ibuprofen and aspirin is not recommended.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#69

Post by davikr »

moritzwarhier wrote: post #63
oliveiracwb wrote: post #52

I live in Brazil. We have broad access to non-steroidal anti-inflammatory drugs. Even the best-known medicines have unexpected and unknown adverse effects: in general and specifically in people with unexpected genetic, enzymatic, and protein variations. This has no solution. The medicine acts differently in each body, which is subtly diverse from the others. I see a lot of research criticizing any "old" general medic…

Interesting how you put metamizole at #1 for long-term treatment. As far as my experience goes, many doctors do the same in Germany. On the other hand, I've heard that the medication is banned in many other countries. I guess the safest way is to take up the treatment in a hospital, to check for immediate bad reactions. On the other hand, like with many medications, severe allergies and individual sensibilities causi…

Metamizole is safe to take on the long-term, which is not the case for NSAIDs (nephrotoxic) and corticosteroids.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#70

Post by davikr »

thisislife2 wrote: post #30
de6u99er wrote: post #9

Can the effects of a drug on the body be reversed after a person stops taking it?

Yes, in most cases. Or are you specifically asking about Paracetamol?

For paracetamol intoxication, there is n-acetylcysteine.
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