Paracetamol disrupts early embryogenesis by cell cycle inhibition
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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#2Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle.
I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#3> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development."
Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#4Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.
I think rapid cell division might occur during embryo development. Not a biologist. Just a guess.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#5Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.
The authors touch on potential wider implications in the abstract:
> These results suggest that APAP should be used with caution by women attempting to conceive. Given that cell division is fundamental to all development, further investigation is now warranted to substantiate these findings and to elucidate possible implications for other developmental processes, such as gonadal and brain differentiation.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#6> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development." Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.
Nature really, really, really wants you to have kids. It took us collectively as a species most of our existence to find genuinely effective methods to alter our biology sufficient to block this process, and we still have a hard time doing it without dramatically impacting the host organism.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#7It's probably worth mentioning that this drug is called Acetaminophen in the US, and is the active ingredient in Tylenol and other over the counter medicines.
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#8It's probably worth mentioning that this drug is called Acetaminophen in the US, and is the active ingredient in Tylenol and other over the counter medicines.
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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#9Can the effects of a drug on the body be reversed after a person stops taking it?
Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition
#10Acetaminophen/Paracetamol is a cox3 inhibitor
it also messes with bone formation so be careful using it for any length of time
especially after athletic activity