Live data from Hacker News

Significant breakthrough in search for Parkinson's biomarker

michaeljfox.org

61–70 of 196 posts

Re: Significant breakthrough in search for Parkinson's biomarker

#61

I wonder if there is any relation to the odorous biomarker that dogs can sniff out in Parkinson’s patients: https://pubmed.ncbi.nlm.nih.gov/36054272/

First discovered by this Scottish woman being able to detect the smell herself https://www.theguardian.com/society/2022/sep/07/woman-who-ca...

Re: Significant breakthrough in search for Parkinson's biomarker

#62
post #45
post #20

Earlier quoted context omitted.

No way. About five years ago there was a quack-y study about reducing death in sepsis which called for high-dose vitamin C, thiamine and steroids. None of these are patent protected. The first study purported to show a 100% reduction in mortality. There were many RCTs done after this which did not bear out the effect, and it has now essentially been proven to be ineffective. it is possible to fund studies without ind…

Who actually thought that steroids help with an infection? Don't those usually make you more susceptible?

If most of the actual harm is being done by your immune system going into overdrive, then yeah, steroids can help. You'd want to simultaneously treat the infection, of course.

"Multiple randomized trials indicate that systemic corticosteroid therapy improves clinical outcomes and reduces mortality in hospitalized patients with COVID-19 who require supplemental oxygen, presumably by mitigating the COVID-19-induced systemic inflammatory response that can lead to lung injury and multisystem organ dysfunction."

https://www.covid19treatmentguidelines.nih.gov/therapies/imm...

But yes, you're also right that it usually makes you more susceptible to infection because your immune system isn't working as hard.

Re: Significant breakthrough in search for Parkinson's biomarker

#63
post #45
post #20

Earlier quoted context omitted.

No way. About five years ago there was a quack-y study about reducing death in sepsis which called for high-dose vitamin C, thiamine and steroids. None of these are patent protected. The first study purported to show a 100% reduction in mortality. There were many RCTs done after this which did not bear out the effect, and it has now essentially been proven to be ineffective. it is possible to fund studies without ind…

Who actually thought that steroids help with an infection? Don't those usually make you more susceptible?

Chronically, yes. Sometimes they can help address a more serious acute issue.

Re: Significant breakthrough in search for Parkinson's biomarker

#64
post #36
post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

Published in the "Journal of Integrative and Complementary Medicine", "The leading peer-reviewed journal providing scientific research for the evaluation and integration of complementary medicine into mainstream medical practice." "Integrative and Complementary Medicine" is a fancy way of saying quackery. Also, the video you linked to is on a channel run by a person describing himself as "a certified functional medic…

[deleted]

Re: Significant breakthrough in search for Parkinson's biomarker

#65
post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

> 100 mg of thiamine administered intramuscularly twice a week Is it possible to get anywhere near this much with dietary thiamine?

I read somewhere that gut can only let around 80mg thiamine/day and gut gets saturated over time, so only IM/IV would work long-term.

Re: Significant breakthrough in search for Parkinson's biomarker

#66
post #43

Earlier quoted context omitted.

>This is likely on the same level as horse dewormer for COVID You mean something that's demonstrated to have a statistically significant protective effect in a majority of studies but was attacked mercilessly by the pharma industry and the media they fund because they can't profit from a generic drug like that? https://c19ivm.org/meta.html

Looks great .. dive in (talk to your local professional epidemiologist) and it's a skewed collection of low N studies mixed in with studies in regions with large intestinal parasite issues. Does horse dewormer do anything significant for large populations in first world countries? No. ( Save for regions with a intestinal parasite problem ) Elsewhere it gets rid of a significant number of parasites, making people heal…

[flagged]

Re: Significant breakthrough in search for Parkinson's biomarker

#67
post #10
post #6

I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…

If this Was discovered 10 years ago, I’m assuming it must be fairly limited in helping, or the results haven’t lasted or something?

Most doctors would laugh at vitamin supplementation even at pharmaceutic megadoses despite people reporting they feel much better. I have seen both GPs and a neurosurgeon laughing about it.

Re: Significant breakthrough in search for Parkinson's biomarker

#69
post #43

Earlier quoted context omitted.

Looks great .. dive in (talk to your local professional epidemiologist) and it's a skewed collection of low N studies mixed in with studies in regions with large intestinal parasite issues. Does horse dewormer do anything significant for large populations in first world countries? No. ( Save for regions with a intestinal parasite problem ) Elsewhere it gets rid of a significant number of parasites, making people heal…

[flagged]

Fair point, it's also effective against a wider range of parasites, head lice, eyelash mites, and skin conditions.

In the case of COVID in populations sans those conditions .. not so much.

Re: Significant breakthrough in search for Parkinson's biomarker

#70
post #43

Earlier quoted context omitted.

Looks great .. dive in (talk to your local professional epidemiologist) and it's a skewed collection of low N studies mixed in with studies in regions with large intestinal parasite issues. Does horse dewormer do anything significant for large populations in first world countries? No. ( Save for regions with a intestinal parasite problem ) Elsewhere it gets rid of a significant number of parasites, making people heal…

[flagged]

The fact that the only part of everything they said you have any response for is the term they used to describe the medication, and then used it to dismiss anything else - that doesn't make you seem especially free of irrational thinking yourself.
Post reply on HN