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Covid-19 Vaccine Candidates

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61–65 of 65 posts

Re: Covid-19 Vaccine Candidates

#61

Earlier quoted context omitted.

Third option: we fight it with drugs and we prevent / reduce hospitalizations, and it becomes a disease like every other.

The obvious comparison is tuberculosis, where vaccination (albeit not universal vaccination) is a critical component of our control measures. Even if we find a strongly effective treatment, which I agree there's reason for optimism on, we'll still want a vaccine.

Yeah, lockdown == prevent. ICU == treat. At the moment thats all we have

Re: Covid-19 Vaccine Candidates

#62
post #34

Earlier quoted context omitted.

Previous pandemics (most notably 1918 Spanish flu) have “disappeared” in the sense that they had either exhausted the pool of hosts and had no natural reservoir with which to fall back on or they mutated to become less deadly or less symptomatic.

How does mutating eradicate the non-mutated individuals?

My personal theory is that lethal mutations or the ones that cause severe symptoms get detected and isolated where possible, while the mutations that cause only mild or no symptoms can continue spreading silently without anyone noticing. If both create the same immunity, the non lethal mutations will win. If this theory holds, testing only if a person is showing symptoms would be the right thing to do. Filter the dangerous mutations, let the other ones spread.

Re: Covid-19 Vaccine Candidates

#63
post #34

Earlier quoted context omitted.

Previous pandemics (most notably 1918 Spanish flu) have “disappeared” in the sense that they had either exhausted the pool of hosts and had no natural reservoir with which to fall back on or they mutated to become less deadly or less symptomatic.

How does mutating eradicate the non-mutated individuals?

A mutated virus that spreads faster gives immunity to the hosts it infects from the ones that spread slower. The hope is that the more transmissible strain is also less lethal.

Re: Covid-19 Vaccine Candidates

#64

Earlier quoted context omitted.

The obvious comparison is tuberculosis, where vaccination (albeit not universal vaccination) is a critical component of our control measures. Even if we find a strongly effective treatment, which I agree there's reason for optimism on, we'll still want a vaccine.

Yeah, lockdown == prevent. ICU == treat. At the moment thats all we have

Many doctors are actually experimenting different treatments, even handling in the ICU has shifted compared to two months ago.

The problem is that most of the pharmacological evidence is sparse and anecdotal at worst (except for remedisivir, and now lopinavir/ritonavir/ribavirin/interferon beta). Trials are ongoing and should at least give better answers, or hints.

Protocols change among countries or even across hospitals, so it's kind of hard to figure out which treatment is best. There's a lot of road to cover to come to proper treatments, but if we are to believe case reports, it is undoubtedly much better than when the pandemic started hitting the West.

Re: Covid-19 Vaccine Candidates

#65
post #50
post #42

Earlier quoted context omitted.

There are plenty of people under 65 who are being killed or suffering major medical issues due to COVID-19. A friend of mine is in great health, 40, and spent 6 days in the ICU and may never recover fully (lung function damage). A vaccine would be great.

As I understand it its a very small proportion of people that age.

Roughly 25% of deaths in the US are people under 65. I think those people and their families would see the value in a vaccine.
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