61–70 of 198 posts
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Plus ça change. I wouldn't have thought racism would become popular again, but here we are.
Or, well, victorian tiptoeing around language becoming popular again, to avoid saying the obvious: most rich people in our society are white...
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> So, this (lousy, but interesting) study is basically "fasting by using drugs." That sounds to me like a big deal, given that most people find fasting difficult (and unpleasant).
Fasting is easy and fun, you just have to work up to it. You can just go from zero to not eating for a week. Building up your tolerance to it takes a bit, like anything else, but when you do it improves mental acuity, gets you a general sense of well-being and energy too.
1) DHEA is not a diabetes med. In fact it's a steroid (not really an anabolic one, though it is a precursor to anabolics) and illegal in the EU. It is a substance which is lowered in older people, so older people supplement with it. 2) Metformin is a diabetes med, and it's used by antiaging enthusiasts independently and along with growth hormone 3) Fasting creates larger growth hormone spikes, and improves sugar clea…
44 yo male. DHEA is amazing. In times of stress, it restores my libido and ends my depressive cycle. I don't take it every day, but I definitely keep it close by.
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44 yo male. DHEA is amazing. In times of stress, it restores my libido and ends my depressive cycle. I don't take it every day, but I definitely keep it close by.
36 year old male here. Using metformin to artificially lower my blood sugar level to help keep weight off and for life extension purposes (asked my doctor for a prescription at my annual physical, said "sure, go for it"). Highly recommend it.
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36 year old male here. Using metformin to artificially lower my blood sugar level to help keep weight off and for life extension purposes (asked my doctor for a prescription at my annual physical, said "sure, go for it"). Highly recommend it.
"Sure, go for it" sure sounds like the next Opioid epidemic.
Would you not at least try to live a bit longer for only $25/year and a once a day pill?
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"Sure, go for it" sure sounds like the next Opioid epidemic.
Metformin is fairly safe as far as pharma goes; it requires a high dosage to be toxic, and the primary side effect is gastrointestinal distress. It's also a cheap generic (~5 cents/pill, costs me $2/month). It would be unfair to lump it in with the opioid epidemic, considering the differences. Would you not at least try to live a bit longer for only $25/year and a once a day pill?
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Wouldn't a gene prefer to transmit copies of itself into descendants that replace all the other genes in the DNA it shares, with better fitness-maximizing ones? That is, if a gene's options are "copy into clone" or "copy into 100% optimal genetic superman, with the only common gene being me , left completely untouched", I assume any given gene would "choose" the latter. Which is to say, presuming a given gene is alre…
Yes, if a gene's surrounded by copies of itself, then there might be certain scenarios where it will destroy a copy of itself to help other copies of the same gene. For example apoptosis happens all the time in human cells. If a cell believes it's infected by a virus or a cancerous mutation, it will voluntarily destroy itself. That's because its continued existence threatens its genetically identical cellular neighbo…
Which means that, if there's a trade-off that involves killing the current host of the gene, in exchange for creating a new host (a descendant) that has the same gene, but is otherwise more inclusively-fit because it has better other genes—then any given gene will "want" to take that trade. Thus the evolution of reproductive strategies that require the deaths of one or both parents.
Mate-guarding (and, really, sexual reproduction preference generally) can be understood as a desire of your more-fit genes, to kick out your less-fit genes and replace them (in your descendants) with more-fit immigrant genes, to build a more-inclusively-fit descendant where the gene has higher likelihood of continuing the next step of exponential-spread-to-fixation.
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Metformin is fairly safe as far as pharma goes; it requires a high dosage to be toxic, and the primary side effect is gastrointestinal distress. It's also a cheap generic (~5 cents/pill, costs me $2/month). It would be unfair to lump it in with the opioid epidemic, considering the differences. Would you not at least try to live a bit longer for only $25/year and a once a day pill?
Berberine is OTC. Not sure what relative risk profiles are. But yes, it's absolutely not comparable to opioids.
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> So, this (lousy, but interesting) study is basically "fasting by using drugs." That sounds to me like a big deal, given that most people find fasting difficult (and unpleasant).
Fasting is easy and fun, you just have to work up to it. You can just go from zero to not eating for a week. Building up your tolerance to it takes a bit, like anything else, but when you do it improves mental acuity, gets you a general sense of well-being and energy too.
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"Sure, go for it" sure sounds like the next Opioid epidemic.
Metformin is fairly safe as far as pharma goes; it requires a high dosage to be toxic, and the primary side effect is gastrointestinal distress. It's also a cheap generic (~5 cents/pill, costs me $2/month). It would be unfair to lump it in with the opioid epidemic, considering the differences. Would you not at least try to live a bit longer for only $25/year and a once a day pill?