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First physiological test for autism proves high accuracy in second trial

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Re: First physiological test for autism proves high accuracy in second trial

#61
post #38

Earlier quoted context omitted.

It was more for the aesthetic of the sentence, but if you have a spectrum including 'normalcy' that is infinite width and infinite height, with x being ability (a combined measurement of communication ability, sensitivities, etc) and y being level of function, it is possible to include 'normalcy' as it is defined at the farthest top right corner. This could even have more dimensions to it, represented as 0-1 on each.…

This is wrong twice I'm afraid. First: a graph with two infinite dimensions doesn't have a top right point, it has a top right extent. Second: when graphing, you don't get to pick what the normal is. That's a property of the graph. It is not the (impossible) property you've described.

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Re: First physiological test for autism proves high accuracy in second trial

#62
post #38

Earlier quoted context omitted.

It was more for the aesthetic of the sentence, but if you have a spectrum including 'normalcy' that is infinite width and infinite height, with x being ability (a combined measurement of communication ability, sensitivities, etc) and y being level of function, it is possible to include 'normalcy' as it is defined at the farthest top right corner. This could even have more dimensions to it, represented as 0-1 on each.…

This is wrong twice I'm afraid. First: a graph with two infinite dimensions doesn't have a top right point, it has a top right extent. Second: when graphing, you don't get to pick what the normal is. That's a property of the graph. It is not the (impossible) property you've described.

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Re: First physiological test for autism proves high accuracy in second trial

#63
post #38

Earlier quoted context omitted.

> spectrum is of infinite width and infinite height If this were true, everyone is diagnosable.

It was more for the aesthetic of the sentence, but if you have a spectrum including 'normalcy' that is infinite width and infinite height, with x being ability (a combined measurement of communication ability, sensitivities, etc) and y being level of function, it is possible to include 'normalcy' as it is defined at the farthest top right corner. This could even have more dimensions to it, represented as 0-1 on each.…

[deleted]

Re: First physiological test for autism proves high accuracy in second trial

#64
post #38

Earlier quoted context omitted.

It was more for the aesthetic of the sentence, but if you have a spectrum including 'normalcy' that is infinite width and infinite height, with x being ability (a combined measurement of communication ability, sensitivities, etc) and y being level of function, it is possible to include 'normalcy' as it is defined at the farthest top right corner. This could even have more dimensions to it, represented as 0-1 on each.…

This is wrong twice I'm afraid. First: a graph with two infinite dimensions doesn't have a top right point, it has a top right extent. Second: when graphing, you don't get to pick what the normal is. That's a property of the graph. It is not the (impossible) property you've described.

Choosing the normal in this case would mean the most common among the population would it not?

Re: First physiological test for autism proves high accuracy in second trial

#65
post #64

Earlier quoted context omitted.

This is wrong twice I'm afraid. First: a graph with two infinite dimensions doesn't have a top right point, it has a top right extent. Second: when graphing, you don't get to pick what the normal is. That's a property of the graph. It is not the (impossible) property you've described.

Choosing the normal in this case would mean the most common among the population would it not?

[deleted]

Re: First physiological test for autism proves high accuracy in second trial

#66
post #5
post #4

Very surprising result. I don't think I've ever heard of a blood test for a mental disorder -- at least, not one that actually works.

Be careful about that kind of wording. I and friends who're on the spectrum don't consider it a "mental disorder". It's simply a physiological difference, one that theoretically can be tested for.

Be careful about that kind of wording. Those of us with loved ones who have severe autism consider it a "mental disorder" and not simply a psychological difference. We'd really love for all of the "neurodivergent" people to have their own diagnosis.

Re: First physiological test for autism proves high accuracy in second trial

#67
post #47

Earlier quoted context omitted.

That seams reasonable enough. I have two thoughts: a) this risks become a personality test , which are notoriously poor as a medical diagnosis tool, and b) I don’t think we (society) should be in a hurry to slap a medical diagnosis on everything.

I don't agree with slapping a diagnosis on anything either, but I think it could be a reasonable tool for people who are in the process of being diagnosed, or looking to better understand their character traits combined while going through the sometimes complicated process of being diagnosed.

Good points.

I always upvote thoughtful responses even if I generally disagree with the overall theme.

As is typically the case, I’m probably wrong and will end up, over time, holding opinions opposed to my present collection, so I try not to stifle divergent opinions.

Re: First physiological test for autism proves high accuracy in second trial

#68
post #5

Earlier quoted context omitted.

Be careful about that kind of wording. I and friends who're on the spectrum don't consider it a "mental disorder". It's simply a physiological difference, one that theoretically can be tested for.

Be careful about that kind of wording. Those of us with loved ones who have severe autism consider it a "mental disorder" and not simply a psychological difference. We'd really love for all of the "neurodivergent" people to have their own diagnosis.

Thanks, but I care more about what a person with autism says than somebody who simply knows one.

Re: First physiological test for autism proves high accuracy in second trial

#69

Earlier quoted context omitted.

I wouldn't use this as a supporting argument. Didn't DSM-3 classify homosexuality as a disorder?

Really? A widely recognized reference manual is blanket discredited because it made a mistake in the past (1952-1974, not DSM-3)?

That makes it a book in which some statements are social reflections rather than statements rooted in good science, which makes other such statements somewhat suspect.

It doesn't mean you should reject the whole thing out of hand but it might be a good idea to try to figure out how much of it is todays bias rather than good science in cases where that is warranted.

Re: First physiological test for autism proves high accuracy in second trial

#70

Earlier quoted context omitted.

It's 88% correct classification on a validation data set consisting of 154 patients diagnosed with ASD. Their validation dataset did not contain a "typically developing" population since there's only one dataset for that data and it was consumed in their model generation. Their training data resulted in a 5% misclassification rate of their controls - that is 5% of patients that were not diagnosed with ASD in current…

If you give the test to everyone, your results are: ~4.9% incorrectly diagnosed with autism (0.05 x .983) ~1.5% correctly diagnosed with autism (0.88 x 0.017) Thus, 76% of those diagnosed would be diagnosed incorrectly.

That's true in a statistical sense. Or it's possible that the human-observers are less accurate about autism than this brain scan.

It's unclear if those who have the odd brain structure but aren't diagnosed are entirely asymptomatic.

Also they may be non-autistic in spite of this brain pattern, but nonetheless have a genetic predisposition to pass it on. Big step.

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