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The mutation that helps Delta spread

nature.com

591–600 of 641 posts

Re: The mutation that helps Delta spread

#591

Covid is going to be endemic like the flu and cold. It's not going to be eradicated, unfortunately, and I don't think we've come to terms with this yet. Now what's our plan exactly? Get vaccinated every 6 - 12 months indefinitely and always wear masks? What's our goal and what's our new normal?

[deleted]

Re: The mutation that helps Delta spread

#593
post #151

Purely anecdotal but I'm double vaccinated (Astra Zeneca) and I caught Covid recently. It was probably Delta as 99% of cases in UK are. I know of quite a few vaccinated friends who've caught it recently too. Mainly AZ I think but one was Pfizer (single jabbed). Anyway, none of us had severe illness although I felt pretty rough for a few days like I had a really bad cold and smell went for a week completely. I was bas…

There’s a question of preferences that too often gets buried in this debate. If Covid becomes endemic at around its current severity, what level of pandemic restrictions are you willing to accept forever? For me personally, Covid would have to be at least 100 times worse before I’d support masking forever. But I get the sense that some people barely see any downside to it. I think these cross-views drive so much if t…

> But because we’re not talking about the hard long-term questions we’re getting bogged down in largely short term spats about case spikes, vaccine boosters, etc.

Masking is not a hard long-term question though. Masking is easy and doesn't require much.

Restrictions in liberties implemented through a mandatory covid pass to enter a restaurant, a concert hall, cross a border or travel too far, mandatory vaccinations for certain working categories of people, etc. are way harder.

Re: The mutation that helps Delta spread

#594

Earlier quoted context omitted.

We're in the middle of a novel pandemic and children are apparently filling up ICUs, I could care less about what people on hackernews's 'preferences' on masks are. Let's be grown up and listen to the Doctors.

> children are apparently filling up ICUs They are??

It's unclear at this point, but it's not looking great

https://yourlocalepidemiologist.substack.com/p/pediatric-num...

Re: The mutation that helps Delta spread

#595
post #76

Earlier quoted context omitted.

Take Vitamin D/C/Zinc/Niacin and build up natural immunity?

There's a social-acceptability phenomenon where people say one thing (e.g. in surveys) and do another (e.g. what they buy). Relatively early in 2020, some grocery and pharmacy shelves were completely emptied of Vit C/D/Zinc/Quercetin. When they were restocked, they would sell out again, even with per-customer quotas. This took place even with a complete news blackout on early treatments. As with HCQ/Ivermectin, we ha…

CQ doesn’t work in the real world as opposed to in the lab because the virus uses TMPRSS2 as opposed to cathepsins to enter.

Re: The mutation that helps Delta spread

#596
post #548

Earlier quoted context omitted.

Please tell me you're joking.

OP is probably making some kind of reference to this: https://www.bmj.com/content/373/bmj.n954 I think they’ve got things a bit mixed up re the spike protein being the crucial element, though. We now know beyond doubt that the risk of blood clots associated with any of the major vaccines is tiny, and very probably zero. Despite a lot of scare stories in the media, there has never really been any good evidence of a li…

>> If the vaccines were dangerous we’d be seeing their harmful effects on a massive scale by now.

That's a bit all-or-nothing. There have been cases of bad reactions to them (small scale). That's not my point though, and to be clear I'm not anti-vax, just wondering if the spike proteins actually cause damage, possibly cumulative. I don't recall where I got the idea that they are responsible for damage though.

Re: The mutation that helps Delta spread

#597

Earlier quoted context omitted.

>Let me approach it from another angle. Pre-vaccine, it appears that Covid roughly doubled everyone's all-cause mortality.[1] Like it killed 30 year olds at a much lower rate than 90 year olds, but 30 year olds have a much lower baseline mortality to begin with. This isn't an exact relationship, but approximately about double mortality across the board. (Even interestingly enough men's excess Covid death rate is abou…

>Covid would have way higher stats if it was allowed to spread unrestricted. This is scientifically false; there's no correlation between lockdown severity and covid fatality rates. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5... : " Lastly, government actions such as border closures, full lockdowns, and a high rate of COVID-19 testing were not associated with statistically significant reductions in t…

In Western Australia it's worked really well for us. Meanwhile NSW is suffering dearly.

Re: The mutation that helps Delta spread

#598
post #548

Earlier quoted context omitted.

OP is probably making some kind of reference to this: https://www.bmj.com/content/373/bmj.n954 I think they’ve got things a bit mixed up re the spike protein being the crucial element, though. We now know beyond doubt that the risk of blood clots associated with any of the major vaccines is tiny, and very probably zero. Despite a lot of scare stories in the media, there has never really been any good evidence of a li…

>> If the vaccines were dangerous we’d be seeing their harmful effects on a massive scale by now. That's a bit all-or-nothing. There have been cases of bad reactions to them (small scale). That's not my point though, and to be clear I'm not anti-vax, just wondering if the spike proteins actually cause damage, possibly cumulative. I don't recall where I got the idea that they are responsible for damage though.

It’s not all or nothing. It’s the only sensible conclusion that can be drawn after hundreds of millions of vaccinations. We know that the associated risks are tiny. There is always a non-zero risk from being injected with anything at all, but there is no reasonable sense in which COVID vaccines are “dangerous”.

> and to be clear I'm not anti-vax, just wondering if the spike proteins actually cause damage, possibly cumulative. I don't recall where I got the idea that they are responsible for damage though.

If you can’t even remember the source, it’s maybe not such a great idea to spread these sorts of unfounded rumors in the middle of a public health crisis.

Re: The mutation that helps Delta spread

#599
post #522
post #377

Earlier quoted context omitted.

Less dangerous on an average individual level, more dangerous since its so contagious and can infect every last unvaccinated person who doesn't have antibodies (and a few who do).

I haven’t seen any credible evidence yet that delta is less dangerous at the individual level than alpha or than the original virus. We know that if a person is vaccinated, then exposure to the original variant is less dangerous than exposure to delta (based on limited controlled studies).

It’s less dangerous on an individual level because most individuals are vaccinated and most of those who aren’t are in low risk groups

Re: The mutation that helps Delta spread

#600
post #151

Purely anecdotal but I'm double vaccinated (Astra Zeneca) and I caught Covid recently. It was probably Delta as 99% of cases in UK are. I know of quite a few vaccinated friends who've caught it recently too. Mainly AZ I think but one was Pfizer (single jabbed). Anyway, none of us had severe illness although I felt pretty rough for a few days like I had a really bad cold and smell went for a week completely. I was bas…

There’s a question of preferences that too often gets buried in this debate. If Covid becomes endemic at around its current severity, what level of pandemic restrictions are you willing to accept forever? For me personally, Covid would have to be at least 100 times worse before I’d support masking forever. But I get the sense that some people barely see any downside to it. I think these cross-views drive so much if t…

Well in a year or two, barring extra bad mutations, well have reached a Covid steady state of sorts. Right now we’re still very much in the initial phase.

Are you saying you want mask restrictions to end now or are you saying you support them until we’re out of the initial phases in a year or so?

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