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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#541

Post by faangguyindia »

7734128 wrote: post #406
faangguyindia wrote: post #151

Earlier quoted context omitted.

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care? Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? if there is no resistance, simply prescribin…

I have a hard time imagining an actual human being as hateful as you are. Why would you spending so much energy trying to make people feel bad about an issue they have? I spent every ounce of effort I could muster last year to lose weight and dropped 36 kg, however there was never a point where that got easy to maintain, where my body wasn't screaming at me to eat. Crying oneself to sleep from hunger after walking 20…

>I spent every ounce of effort I could muster last year to lose weight and dropped 36 kg, however there was never a point where that got easy to maintain, where my body wasn't screaming at me to eat. Crying oneself to sleep from hunger after walking 20000 steps per day is not how I could live the rest of my life

Basically, you walking 20,000 boosts your maintenance calories up, since

deficit = tdee (maintenance) - intake

Once you've lost the weight, there is no need to maintain "deficit" to stay at that weight when you do not understand something as simple as this. I’ve no doubt what you did was perhaps over-restrictive, which made you suffer.

which means no you do not need to walk 20K steps for life, nor you need to perma lower your calorie intake, you just need to eat at maintenance calories after getting to your target weight.

>There are people literally starving to death because they can't force themselves to eat and of course many more people eating until it kills them.

They are rare, so rare i don't run into them at all.

Re: What Ozempic does to the gut-brain axis

#542

Post by faangguyindia »

s1artibartfast wrote: post #513
amanaplanacanal wrote: post #374

Earlier quoted context omitted.

I don't think I could do it, but 3.5 cups of peanut butter would get you there. Or four 16 ounce ribeyes.

It doesnt have to be one sitting. Eat 2500 diet and add a cup of roast nuts twice a day and you are basically there. Moreover, you dont need to eat anywhere close to 5k to be morbidly obese. 1 cup of roast nuts over TDEE will gain you 100lbs in a couple short years

Assuming you maintain same activity level, the increase in weight wouldn't be that simple.

TDEE rises as body weight rises (heavier body burns more)

Overfeeding increases NEAT in some people (more fidgeting, movement)

Re: What Ozempic does to the gut-brain axis

#543

Post by Scalestein »

cjbgkagh wrote: post #484
Scalestein wrote: post #436

Earlier quoted context omitted.

Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically. Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.

That reaction could very much be dose dependent. I think those in most need of the effect start out very hypersensitive to it and that reaction could easily obscure any benefits. I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants. My overall theory is that a c…

Super interesting - friend is on a Adderall and Trazedone stack for energy/focus + sleep aid. Amitriptyline looks very interesting though I don't think they've tried that.

Thanks for the information, it's such a frustrating condition with a dearth of good information and research.

Re: What Ozempic does to the gut-brain axis

#545

Post by butlike »

babuskov wrote: post #367
mycall wrote: post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

That's the problem with the definition of "healthy". No single food is "healthy" on it's own. It's a wrong way to look at it and why most people fail at finding a good diet. There's no super food you can just eat unlimited amounts of. A diet can be healthy if it's the nutrient combination of different foods that result in certain number of calories, protein, fat, carbs, minerals and vitamins per unit of time.

The more colorful the plate, generally; the better it is for you.

Re: What Ozempic does to the gut-brain axis

#546

Post by butlike »

faangguyindia wrote: post #275
mycall wrote: post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.

I don't think you'll struggle to get tons of calories out of whole foods, but you'll be satiated faster eating whole foods, which will in all practicality, mean you ate less.

Re: What Ozempic does to the gut-brain axis

#547

Post by butlike »

wpm wrote: post #21
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

But isn't the point to not have to be tethered to a medication forever?

Re: What Ozempic does to the gut-brain axis

#548

Post by habinero »

SoftTalker wrote: post #452
habinero wrote: post #341

Earlier quoted context omitted.

Yeah, that does nothing. I love to cook, and I can cook super healthy and like it. I'm still hungry lol. There's a part of my brain that constantly thinks about food. It's like tinnitus. GLPs stopped that cold.

Do you have addictive/compulsive tendencies in other things besides eating? Did GLPs reduce those as well (I've heard that it does)? For me, stopping fast food, most restaurant/takeout food, and processed food such as bread, pastries, chips, cookies, and any prepared/convenient "snack" items drastically reduced how often I felt hungry or just wanted to eat for no apparent reason.

No, I don't have anything like that. I have a friend with diagnosed OCD and that is an entirely different beast. And I have tried cutting that stuff out (was never big on most of it anyway) and it did absolutely nothing for this sort of thing lol.

Tinnitus really is the best way I can describe it. I didn't even realize how pervasive it was until it shut off.

Re: What Ozempic does to the gut-brain axis

#549

Post by fwip »

hack1312 wrote: post #272
macintux wrote: post #228

Earlier quoted context omitted.

At a large enough scale, being beholden to a drug is far more sustainable. We’ve tried shaming people into being healthy. Amazingly enough, it doesn’t work very well.

You claim shame was tried and was unsuccessful thus we should drug people. But what about the opposite of shame? Education, encouragement, non-judgementalism, and providing all other support required.

Feel free to cite any intervention that is proven to be longitudinally successful over a long time frame.

Re: What Ozempic does to the gut-brain axis

#550

Post by mathgladiator »

cagenut wrote: post #403
dyauspitr wrote: post #47

What’s the downside to this magical drug. There has to be a downside…

the downside is it allows us to continue to avoid solving the real problem ideologues will tell you this is that all mankind suddenly lost their ability to exert self-discipline a few decades ago science points to a broad combination of things like corn syrup and seed oils simply making food too addictivly-rewarding and calorie rich for our nervous and endocrine systems to handle. so, do we reform the farm bill and f…

Solving the underlying problem has been amazing. I wish more people could do it.

I have given up helping others since my solution was to embrace a carnivore lifestyle. But then im just in a tribal cult with amazing health.

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