Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

What Ozempic does to the gut-brain axis

psychologytoday.com

Post reply on HN
Print view View original

511–520 of 555 posts

Re: What Ozempic does to the gut-brain axis

#511

Post by s1artibartfast »

imajoo wrote: post #467
theturtletalks wrote: post #280

Earlier quoted context omitted.

The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.

Sorry but isn’t GI about how “sugary” a food is…? I don’t believe it doesn’t measure to do how full you feel. https://www.verywellhealth.com/glycemic-index-vs-load-521436...

Not directly but they can be related. GI is about how quickly the carbs in food are metabolized and how quickly sugar is released into the blood.

Blood sugars spikes then drops can have different impacts on food appetite.

Re: What Ozempic does to the gut-brain axis

#512

Post by catigula »

dotcoma wrote: post #232
catigula wrote: post #218

Earlier quoted context omitted.

I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.

Good for you, but this mere fact does not mean it’s ideal. Not a doctor, but I would at least try to look into this. Best of luck!

Why do you think I haven’t looked into it?

You’re not providing anything of note, so merely saying “I’ve looked into it. I’m good” seems like it’s the correct reply.

Re: What Ozempic does to the gut-brain axis

#513

Post by s1artibartfast »

amanaplanacanal wrote: post #374
faangguyindia wrote: post #324

Earlier quoted context omitted.

What do you eat in those 5000kcal calories? Genuinely curious.

I don't think I could do it, but 3.5 cups of peanut butter would get you there. Or four 16 ounce ribeyes.

It doesnt have to be one sitting. Eat 2500 diet and add a cup of roast nuts twice a day and you are basically there.

Moreover, you dont need to eat anywhere close to 5k to be morbidly obese.

1 cup of roast nuts over TDEE will gain you 100lbs in a couple short years

Re: What Ozempic does to the gut-brain axis

#514

Post by nwienert »

npunt wrote: post #42
barake wrote: post #39

Earlier quoted context omitted.

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

oh say more?

I've been posting about this including here for years now. I wrote a long post about it a while ago here and on Reddit. At time no one was talking about it, and actually my Reddit post was buried behind tons of others which was frustrating at the time given I had basically shared a partial cure.

Now if you search "reddit eds glp-1" or tirzepatide you'll see tons and tons of long threads of people all saying the same thing - it's the only thing that actually helps.

For me it was something of a miracle, I have two overlapping immune issues and it seems to just turn me into a much more normal, functional person. Including fixing my sleep.

Never was overweight beyond maybe ~15lbs btw when I started or took it, and the effects are 100% not because of just fasting or weight loss. I had tried keto and OMAD before, and been at healthy weight my whole life.

There's a definite auto-immune modulating mechanism and it's so strong it seems better than basically most first-class drugs. Even things like prednisone which are like nuclear weapons don't give me relief like Tirzepatide does.

Btw highly recommend Tirzepatide of the three GLP-1 drugs, for me at least it's by far the most effective and least side effects.

Re: What Ozempic does to the gut-brain axis

#515

Post by nwienert »

cjbgkagh wrote: post #432
jelsisi wrote: post #421

Earlier quoted context omitted.

I'm in the same boat! I look very healthy, I'm young and most of my bloodwork is great but I have many autoimmune symptoms. I started on semaglutide 1 week ago and your comment brings me hope.

I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modaf…

Btw I have a couple autoimmune issues and found Tirzepatide strongly preferable to Semaglutide.

Re: What Ozempic does to the gut-brain axis

#516

Post by pandaman »

padjo wrote: post #501
pandaman wrote: post #422

Earlier quoted context omitted.

Define "massive". People do successfully and reliably get in shape through exercise. Aerobic exercise that gets HR up for an hour or more will significantly alter your calorie balance. I agree that more people don't go through exercise rote though.

An hour of fairly vigorous cardio every day will give you what, 3-400 kcals of extra calories to play around? Something you can easily overcome by eating a donut, which you will absolutely crave after that hour and feel you deserve. Exercise is absolutely useless for weight loss if it isn't coupled with a controlled diet.

>An hour of fairly vigorous cardio every day will give you what, 3-400 kcals of extra calories to play around?

This depends on your VO2max/FTP. At very modest 150W FTP it would be ~550 kcal.

> Something you can easily overcome by eating a donut

Don't eat a donut then? It's not like donuts randomly fly into your mouth and you have no control.

>Exercise is absolutely useless for weight loss if it isn't coupled with a controlled diet.

That's obvious. It's not "absolutely" useless as it will take much more effort to gorge on food (e.g. I don't know anyone who would be able to eat a donut after an hour of a vigorous exercise, least crave one) and you also have less time to stuff your face and think of snacks. But it's entirely possible to still overeat while exercising.

Re: What Ozempic does to the gut-brain axis

#518

Post by replwoacause »

s1artibartfast wrote: post #500
replwoacause wrote: post #41

Earlier quoted context omitted.

I've been on Mounjaro for a couple of years. Unfortunately this effect seems to plateau somewhat and you have to bump your dose. I've changed doses 3 times now, so I'm pretty familiar with how long each increase lasts. It still provides some appetite control, but those initial gains, or the honeymoon phase, definitely tapers. Still, I'm better off being on it versus not and I think it allows me to maintain a healthy…

Which was it? Did it plateau or taper? With same dose do you get flat and consistently low appetite or do the effects lose power if you dont up the dose?

It tapered to a plateau. :)

My experience has been the appetite suppression goes down after a while but doesn’t go away entirely. With each change in dose there’s always a more pronounced effect in the beginning. I don’t take it for weight loss though, I take it for T2 and my A1C is a 4.3 so it works very well for that and it’s unlikely I’ll change doses again because it’s well controlled.

Re: What Ozempic does to the gut-brain axis

#519

Post by dgabriel »

QuiEgo wrote: post #264
dgabriel wrote: post #170

Earlier quoted context omitted.

I understand calorie balance. I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now. I have logged every bite that goes into my mouth, and lived with a constant hunger for as long as I could take it. Then I ate until I felt satisfied and gained it all back. I know how many calories are in anything, and I can eyeball any serving size. I've been…

That sucks. If GLP-1s work for you, more power to you. Curious: how big of a calorie deficit did you run, and what was your macro (protein/fat/carbs) balance. My personal experience is going low on carbs (especially added sugars) and high on fiber and protein made running a deficit suck much less in terms of feeling satisfied. Also, a 10% deficit was okay (I was hungry but could mostly ignore it). A 25% deficit was v…

I did a lot of things, but all of them required a massive amount of sustained effort. I like that I can order the food I want to eat at a restaurant without looking up all the calories before I go. I like that I can just live my life without food thoughts taking up 60% of my brain space at any given time.

For some people, diet and lifestyle changes help control blood pressure. Other people need to take meds for the rest of their lives, anyway. We don't shame them for it.

Re: What Ozempic does to the gut-brain axis

#520

Post by microgpt »

Aaargh20318 wrote: post #505
microgpt wrote: post #448

Earlier quoted context omitted.

What do you do with the other 128 hours?

Sit in front of the TV like a zombie because I’m too tired to do anything else.

So that's the problem. Might you suffer from anhedonia, a common part of depression? It can also be ADHD-related. ADHD is a common co-diagnosis of autism which is a common co-diagnosis of using HN, and ADHD basically means your reward system is messed up on all axes, not just the ones that cause AD and H. I'm not diagnosing you, just throwing out words you might possibly look up.
Post reply on HN