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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#501

Post by padjo »

pandaman wrote: post #422
chrisco255 wrote: post #229

Earlier quoted context omitted.

Most people are achieving weight loss by dietary changes. It takes a massive amount of exercise to significantly alter your calorie balance. Definitely good for you either way but most people who exercise also want to be toned or muscular.

Define "massive". People do successfully and reliably get in shape through exercise. Aerobic exercise that gets HR up for an hour or more will significantly alter your calorie balance. I agree that more people don't go through exercise rote though.

An hour of fairly vigorous cardio every day will give you what, 3-400 kcals of extra calories to play around? Something you can easily overcome by eating a donut, which you will absolutely crave after that hour and feel you deserve. Exercise is absolutely useless for weight loss if it isn't coupled with a controlled diet.

Re: What Ozempic does to the gut-brain axis

#502

Post by kube-system »

Jensson wrote: post #477
kube-system wrote: post #287

Earlier quoted context omitted.

It does which is why medically supervised weight loss with GLP1s includes diet recommendations to mitigate this. But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway.

> But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway. "Food noise" is much more than just craving calories, we have cravings for most of the different nutrients we need. That is how people ate a balanced diet in history even though it was much harder to do back then, peasants craved…

My doctor explicitly does target my dosing to “make sure I don’t lose my appetite entirely, but just reduce the food noise”

I think there’s a distinct difference between what people are describing as “food noise” and a normal appetite.

Re: What Ozempic does to the gut-brain axis

#503

Post by fragmede »

raffael_de wrote: post #495
fragmede wrote: post #408

Earlier quoted context omitted.

whatever we learned about gut brain axis dysfunctionality? I thought most of the biggest findings were in that it exists in the first place.

the term "gut feeling" exists for a reason. the findings substantiated this colloquial wisdom and its relevance ... the article hints at it by associating mental disorders with gut microbiome. I wouldn't be surprised at all if it turns out that Ozempic et al. harm this gut/brain cooperation ... I'd bet on it.

How much and how long do you want the bet you go for? How do you even want to define "harms". Let's say there's a road from the gut to the brain. If today's ultra processed food is motorcycles ripping down the road as fast as possible, and Ozempic is the police, saying whoa there, slow down, buddy, then from the POV of the motorcyclists that's harmful, but for everyone else around them, that's good.

Re: What Ozempic does to the gut-brain axis

#504

Post by raffael_de »

fragmede wrote: post #503
raffael_de wrote: post #495

Earlier quoted context omitted.

the term "gut feeling" exists for a reason. the findings substantiated this colloquial wisdom and its relevance ... the article hints at it by associating mental disorders with gut microbiome. I wouldn't be surprised at all if it turns out that Ozempic et al. harm this gut/brain cooperation ... I'd bet on it.

How much and how long do you want the bet you go for? How do you even want to define "harms". Let's say there's a road from the gut to the brain. If today's ultra processed food is motorcycles ripping down the road as fast as possible, and Ozempic is the police, saying whoa there, slow down, buddy, then from the POV of the motorcyclists that's harmful, but for everyone else around them, that's good.

https://en.wikipedia.org/wiki/Straw_man

Re: What Ozempic does to the gut-brain axis

#505

Post by Aaargh20318 »

microgpt wrote: post #448
Aaargh20318 wrote: post #416

Earlier quoted context omitted.

Ah yes, a therapist. One of those people who will try to gaslight you into thinking spending 40 hours a week in dayprison is a meaningful life.

What do you do with the other 128 hours?

Sit in front of the TV like a zombie because I’m too tired to do anything else.

Re: What Ozempic does to the gut-brain axis

#506

Post by gavinray »

OptionOfT wrote: post #36

My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...

Posted prices of Chinese gray market bulk peptides on Twitter recently

It's $95 for 10 vials of 30mg Tirzepatide, which at the highest dose of 15mg/wk, is still 20 weeks for less than $100...

https://x.com/GavinRayDev/status/2067348581418434564/photo/1

Finnrick will even test your peptides if you agree to them publicizing the results and the vendor:

https://www.finnrick.com/products/tirzepatide

Re: What Ozempic does to the gut-brain axis

#507

Post by tqi »

SOLAR_FIELDS wrote: post #138
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

Statins are a well understood mechanism of action for controlling cholesterol. We generally understand that people with cholesterol problems leverage statin therapy to address those, and there is a well audited corpus of placebo controlled double blind trials that demonstrate the efficacy of the solution for statin therapy. If you discontinue the statins, you lose the benefit to some extent. How is this situation fun…

Agree, same can be said of exercise.

I think people consciously or unconsciously consider being overweight a moral failing and so are quick to point out the flaws.

Re: What Ozempic does to the gut-brain axis

#508

Post by s1artibartfast »

gavinray wrote: post #466
mycall wrote: post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

I consumed +11lbs (5.1kg) of food yesterday for only 2,500kcal If you have a stomach and appetite that are capable of consuming the 15 to 20 lb you need to eat 3,500 to 4,000 calories of similar foods, you ought to call a research lab

In what world does that prove you cant get fat eating "healthy" or "whole" foods?

1) you didnt eat the most calorie dense foods

2) you dont need crazy calories to get fat, just above your burn rate.

What part are you confused about?

Re: What Ozempic does to the gut-brain axis

#509

Post by catigula »

derekja wrote: post #236
catigula wrote: post #218

Earlier quoted context omitted.

I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.

The primary concern is reduced stomach acid leading to nutrient deficiencies, particularly b12. There have been some long term studies correlating to dementia as a result. And some studies that have not found this. So the jury is still out, but keeping an eye on some nutritional markers is not a bad idea.

The dementia meta-analyses are a wash. It doesn’t lean strongly either way. I wouldn’t worry about it.

Re: What Ozempic does to the gut-brain axis

#510

Post by catigula »

mapkkk wrote: post #377
catigula wrote: post #218

Earlier quoted context omitted.

I’ve been taking high doses long term for over a decade and I don’t really have any substantial issues.

Definitely not a good idea to be on it longer than 2 months. If we can't treat the underlying condition and the patient needs life-long acid suppression therapy, we switch to H2 receptor antagonists, like cimetidine. Long term PPI use has non-trivial risks, including magnesium and other micronutrient deficiencies, and can lead to things like SIBO and other primarily gut related morbidity. I would definitely suggest s…

I hate to tell you this, but recommending cimetidine basically makes you a modern day sawbones.

I’d recommended getting up to date knowledge about the options before providing advice on them, starting with safer h2 antagonists like famotidine.

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