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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#52Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#53I for one would like to see the data rather than a press release. Is this even serious? A press release with no link to outside twitter? I feel like everything companies, and presidents, say now is directly geared to triggering AI trades. The only thing they are looking at with this drug is people living one more month over existing drugs. THIS IS NOTHING. "The median PFS (progression-free survival) for KEYTRUDA was…
No it isn’t. They did a test with great specificity and got undeniable P values. Now they can refine the action and start saving people. This is a huge, huge win.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#54Earlier quoted context omitted.
Saving a couple million people in the pandemic wasn’t validation enough?
100%. What I meant to say was that this proves that it wasn't somehow a one trick pony.
There is also a mRNU flu vaccine now: https://www.modernatx.com/ir-insights-mflusiva
I don't know if that counts as the same "trick" or not as it's another antiviral vaccine. Not that I disagree with you.
I read that this mRNA flu vaccine can be more effective then the regular annual flu shot, simply because the time to create it is shorter, therefor the guess at what strains will circulate that year is more accurate.
https://pubmed.ncbi.nlm.nih.gov/41701031/
But it is yet more validation. mRNA technology is here, get used to it.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#55Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#56Earlier quoted context omitted.
> They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. Not true. This was correctly disclosed in the trial results as a super super super tail risk. Once they realized that the (minuscule) risk could be even further mitigated by simply spacing out the booster schedule, they adjusted that (Feb 2022). N…
What's more, they found that myocarditis risk was higher in the unvaccinated population after infection. This information didn't get to the so-called "skeptics," who willfully ignored data that didn't fit their conspiracy theory. https://www.heart.org/en/news/2022/08/22/covid-19-infection-...
I also get a kick out of people only looking for side effects they think of as side effects, since they are what people think of as side effects for completely different types of technologies.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#57Substantially better link:
https://www.merck.com/news/merck-and-moderna-announce-phase-...
Still no actual Phase 3 data presented.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#58Earlier quoted context omitted.
> They also left the public in the dark about the risk of vaccine-associated myocarditis, especially in young males, many of whom experienced permanent heart tissue damage. Not true. This was correctly disclosed in the trial results as a super super super tail risk. Once they realized that the (minuscule) risk could be even further mitigated by simply spacing out the booster schedule, they adjusted that (Feb 2022). N…
again. over how long.
What?
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#59Earlier quoted context omitted.
+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.
I didn't know about the UV index or what it meant until like three years ago. It blows my mind I went that long without understanding. It was actually wonderful to learn that I could just see if I needed sunblock based on a 0-10 scale. We never wore sunscreen as kids because we didn't burn. I probably have had three sunburns in my life. Learned once I became an adult that that wasn't sound logic...
I think the Apple Watch or the Weather app or something finally taught me UV index about the same time. Has this information always been readily available? Similarly mind blown about it.
Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
#60I for one would like to see the data rather than a press release. Is this even serious? A press release with no link to outside twitter? I feel like everything companies, and presidents, say now is directly geared to triggering AI trades. The only thing they are looking at with this drug is people living one more month over existing drugs. THIS IS NOTHING. "The median PFS (progression-free survival) for KEYTRUDA was…
1. That's not what progression-free survival means.
2. I don't think AI was mentioned once in this press release.
3. This drug was approved for trial in 2014, so if it had something to do with deep learning, that would actually be a massive announcement.
4. The paragraph immediately following the one you clipped talks about Overall Response Rate (ORR) and throughout the release they discuss Overall Survival (OS).
5. This is not "NOTHING" in statistical terms, but even more so to people with melanoma.