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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#51

Post by pjerem »

jonkoops wrote: post #34
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

As with all things, the poison is in the dose. A tonne of incredibly useful medicine can kill you if dosed incorrectly.

Sure but it’s pretty easy overdose on paracetamol.

Since it’s a mild and really common painkiller, sometimes seen as not dangerous, someone uneducated about it who is really suffering could easily take 3 or 4 times the dose.

Unlike a lot of drugs, you are not going to have a lot of immediate side effects if you overdose on paracetamol. You’ll just horribly die some days after,

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#52

Post by oliveiracwb »

I live in Brazil. We have broad access to non-steroidal anti-inflammatory drugs. Even the best-known medicines have unexpected and unknown adverse effects: in general and specifically in people with unexpected genetic, enzymatic, and protein variations. This has no solution. The medicine acts differently in each body, which is subtly diverse from the others. I see a lot of research criticizing any "old" general medicine and introducing the "new" one. I don't know if this is the case. Every medicine has its rush, half-life, and side effects, and its actions are not fully mapped. My preference for long-term treatments is: dipyrone. Short term: ibuprofen. Lymphatic pain: paracetamol. It may not make sense, but that's how I use it.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#53

Post by beejiu »

propter_hoc wrote: post #35
Xenoamorphous wrote: post #24

Earlier quoted context omitted.

I think Paracetamol is better for fever, but for other pain I always prefer Ibuprofen.

From wikipedia: At a standard dose, paracetamol slightly reduces fever,[13][17][18] though it is inferior to ibuprofen in that respect[19] [13] Warwick C (November 2008). "Paracetamol and fever management". J R Soc Promot Health. 128 (6): 320–323. doi:10.1177/1466424008092794. PMID 19058473. S2CID 25702228. [17] Chiumello D, Gotti M, Vergani G (April 2017). "Paracetamol in fever in critically ill patients-an update".…

> At a standard dose, paracetamol slightly reduces fever,[13][17][18] though it is inferior to ibuprofen in that respect[19]

It's good you can take both at the same time then! (For adults.)

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#54

Post by e40 »

artvandelai wrote: post #50
nine_k wrote: post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

NSAIDs reduce inflammation. Since inflammation is part of healing, they can slow recovery, but they’re useful when inflammation itself is a problem.

paracetamol is not an NSAID.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#55

Post by vanderZwan »

cenamus wrote: post #38
odyssey7 wrote: post #27

Earlier quoted context omitted.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

Same goes for icebaths, they reduce inflammation, which is the whole point of working out.

What about ginger? Because that apparently only downregulates COX-2 without affection COX-1 (most inflammation-reducing drugs affect both)

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#57

Post by Terr_ »

a3w wrote: post #42
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

"Any medicine can be poison" is kinda missing the point.

There is a rich and varied multidimensional field of danger, from aspects like the safety-margin between regular/dangerous dose levels, the chronology of how it can spike or accumulate, whether there's feedback in advance of damage, etc.

Yeah, I can poison myself drinking clean water, but it's hard.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#58

Post by SoftTalker »

bena wrote: post #11
latchkey wrote: post #3

> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development." Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.

This is probably one of those things where the risk is normally small, so small increases cause large changes in percentage. For instance, if spontaneous abortion is normally 1% and smoking increases it to 2%, then that’s a 100% increase. Now, I don’t know the actual numbers, and smoking is just generally not good for one’s health, but I wouldn’t go as far to say things were stacked against you.

Millions of kids have been born to parents who smoked and drank all the way through their pregnancies, especially before the 1970s or so. It raises risks, but doesn’t guarantee bad outcomes.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#59

Post by [deleted] »

jonkoops wrote: post #34
Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

As with all things, the poison is in the dose. A tonne of incredibly useful medicine can kill you if dosed incorrectly.

[deleted]

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#60

Post by docfort »

bena wrote: post #11
latchkey wrote: post #3

> "Smoking and alcohol are established risk factors for spontaneous abortion, underscoring the importance of the chemical environment during embryonic development." Both of my parents are/were heavy smokers drinkers from their teenage years. Mom died of lung cancer from smoking. Kind of wild to think that the odds were really stacked against my birth.

This is probably one of those things where the risk is normally small, so small increases cause large changes in percentage. For instance, if spontaneous abortion is normally 1% and smoking increases it to 2%, then that’s a 100% increase. Now, I don’t know the actual numbers, and smoking is just generally not good for one’s health, but I wouldn’t go as far to say things were stacked against you.

The article says that implantation fails in humans 10-40% of the time. Your point is still valid, but the scale in reality is very significant.
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