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Review of Anti-Aging Drugs

scienceblog.com

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Re: Review of Anti-Aging Drugs

#51

Post by p_ing »

rscho wrote: post #16
ivape wrote: post #6

Would any of the OTC stuff even be effective? Melatonin, NAC, and Berberine.

Truth be told, none of either prescription or OTC stuff has any solid research backing it. Some people, especially on HN are obsessed with living long and are always prompt to try the weirdest experimental stuff. Reasonable people should remember what the COVID period was on this website, and act accordingly...

If you want to live long, be bipolar and take lithium.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7553080

(no don't, it's hell on earth)

Re: Review of Anti-Aging Drugs

#52

Post by gautamcgoel »

Eldt wrote: post #40
bob1029 wrote: post #20

> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…

Do you get acid reflux?

Simple solution: take an antacid, like Tums.

Re: Review of Anti-Aging Drugs

#53

Post by rscho »

obloid wrote: post #49
adamgordonbell wrote: post #3

Earlier quoted context omitted.

Also this: > The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans. And earlier: > Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.

I recently saw a patient with overwhelming MRSA sepsis with multiple foci of infection including epidural abscess (around the spinal cord), and meningitis. This person was taking rapamycin presumably for "life extension" purposes. Almost certainly the immunosuppression from the rapamycin made the infection much worse. I'd be very wary of taking an immunosuppressive drug as an otherwise healthy person for theoretical…

Don't come and spoil our nice individualism with populational effects, you filthy rationalist !

Re: Review of Anti-Aging Drugs

#54

Post by ac29 »

pama wrote: post #15

Be careful when reading such blogs: > Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg). Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.

> Be careful when reading such blogs

I followed a link to another blog post of theirs in which they go on a rant claiming there was a conspiracy to suppress chloroquine and ivermectin as COVID treatments. I dont think anyone should be taking health advice from this person

Re: Review of Anti-Aging Drugs

#55

Post by deadbabe »

How many people can really even afford life extension? As in living all the way into 90s or 100? Your retirement savings have to be pretty solid to enjoy those extra years. It’s not like before, the game has changed.

Re: Review of Anti-Aging Drugs

#56

Post by DrBenCarson »

bob1029 wrote: post #20

> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…

Latest research (as in only ~2m old) dispels that narrative a bit but not entirely. Looks like spermidine is the autophagy signal but they’re not sure fasting does t always increase spermidine

Also…lifting light weights for like 10 minutes a day at home is a lifechanger in the early days

Re: Review of Anti-Aging Drugs

#58

Post by IceHegel »

There's a fascinating tension with anti-aging drugs, which is that your preference would obviously be to take them as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway.

But taking experimental drugs while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake of their 70s in a way they end up regretting, even if there aren't any side effects.

Re: Review of Anti-Aging Drugs

#59

Post by avarun »

A_D_E_P_T wrote: post #41
pama wrote: post #15

Be careful when reading such blogs: > Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg). Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.

lol, that one was really a howler. You're spot on. But for the rest of the forum: The most commonly accepted mouse-to-human conversion is: (D)*(3/37) = H Where D = the mouse dose in mg/kg. H = human dose in mg/kg. So if a 25g mouse eats 0.1% of its bodyweight in taurine, that comes out to 1000mg/kg. It translates to 81mg/kg for a human. If you weigh 100kg, an equivalent daily dose for you is 8.1 grams/day. The rat eq…

In plain English: scale by body weight then divide by 12.

Re: Review of Anti-Aging Drugs

#60

Post by hgomersall »

sigmoid10 wrote: post #43
bob1029 wrote: post #20

> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…

While autophagy does correlate with fasting and some studies link it to health markers, it should be noted that it usually takes at least 18 hours of continued fasting to even start and only goes into full swing after 48 to 72 hours. It is also an extreme cell response that is associated with high levels of cellular stress, which might have understudied long term detrimental effects. A simple calorie reduction either…

Is exercise really a maybe?
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