Would any of the OTC stuff even be effective? Melatonin, NAC, and Berberine.
A good place to read more about these: https://examine.com/supplements/n-acetylcysteine/?show_condi...
Review of Anti-Aging Drugs
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Re: Review of Anti-Aging Drugs
#12[dead]
Re: Review of Anti-Aging Drugs
#13Would any of the OTC stuff even be effective? Melatonin, NAC, and Berberine.
Melatonin is just for jetlag/otherwise shifted sleeping schedule, are people using it as an anti aging drug?
Re: Review of Anti-Aging Drugs
#14Earlier quoted context omitted.
Rapamycin modulates the immune system. I get that he's probably consulting a doctor but can you imagine taking this risk during a pandemic or even in older age? It makes me uncomfortable to play around with these very powerful drugs.
The dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk. I think there are some proper human trials happening but the jury is still out.
> I think there are some proper human trials happening but the jury is still out.
That's exactly my point. No one really knows the risk that they are taking.
Re: Review of Anti-Aging Drugs
#15Be careful when reading such blogs:
> Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg).
Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.
Re: Review of Anti-Aging Drugs
#16Would any of the OTC stuff even be effective? Melatonin, NAC, and Berberine.
Truth be told, none of either prescription or OTC stuff has any solid research backing it. Some people, especially on HN are obsessed with living long and are always prompt to try the weirdest experimental stuff. Reasonable people should remember what the COVID period was on this website, and act accordingly...
Re: Review of Anti-Aging Drugs
#17Be careful when reading such blogs: > Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg). Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.
Lack of pharmacology background doesn't seem like the biggest issue when extrapolating from mouse to human.
Re: Review of Anti-Aging Drugs
#18From the conclusion paragraph: > Your primary life extension program is diet and exercise. Choose a diet that works for you. Stay slim. Considering heart disease is the #1 killer, doing whatever you can to not die from heart disease is the best place for most people to start. Even in 2025, diet and exercise are still king.
And if diet alone isn't getting you to a healthy weight, the GLP-1 drugs are miraculously effective and don't have a lot of downsides aside from cost.
Re: Review of Anti-Aging Drugs
#19A lot of people in the comments are talking about the "problem" of death and approaches to take, but really, the only thing you can do is philosophically make your peace. Anything else at this point is yelling into infinity.
Re: Review of Anti-Aging Drugs
#20> Fast for short intervals regularly, and longer fasts as they feel good to you.
You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle.
Being in a fasted state is as close as you can get to actually reversing aging. Your body engages in a process called autophagy when nutrient-sensing pathways are down-regulated. When you are stuffing your face constantly (i.e., every ~8 hours), there is less opportunity for this mechanism to do its job.