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High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

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Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#51

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Read these articles, maybe it gives some insight. The idea that you need high doses of vitamin D might not be as scientifically sound as you’d think

https://www.devaboone.com/post/vitamin-d-part-1-back-to-basi...

https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st...

https://www.devaboone.com/post/vitamin-d-part-3-the-evidence

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#52

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Not sure why you're being downvoted, so I created an account specifically to respond. I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but…

Exactly the same issue!

I have been trying to increase my Vitamin D levels for 15 years now but I just can't tolerate this supplement.

  Lower dosage: ~500-1000 IE -> side effects come after around 3-4 days of daily intake.
  Higher dosage: ~5000 IE -> side effects after a few hours.
I tried following most advice over here in the past but it did not work: https://web.archive.org/web/20240226035822/https://vitamindw...

I'll just live with my low blood Vitamin D levels.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#53

Earlier quoted context omitted.

No, they weren't, and that's a good suggestion that I need to try.

Get a well-rated softgel form without iffy ingredients like caramel coloring.

I think at this point, they should just go straight to liquid with an eyedropper, no gelatin capsule or anything in order to try and rule out as much as possible.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#54

Earlier quoted context omitted.

Get a well-rated softgel form without iffy ingredients like caramel coloring.

I think at this point, they should just go straight to liquid with an eyedropper, no gelatin capsule or anything in order to try and rule out as much as possible.

The problem with an exposed liquid is that will definitely lose its potency a lot quicker. A softgel keeps the active ingredient somewhat protected from oxidation. It also depends on the level of antioxidant present in the liquid. This matters in the tail end of the bottle.
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