51–60 of 196 posts
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> I'd probably opt for an egg or sperm donation so that any kids produced would have a high probability of having the disease too?
no, so that they don't have a high probability of having a disease because I'd not be passing it on. How did you read anything else into that statement?
I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…
Published in the "Journal of Integrative and Complementary Medicine", "The leading peer-reviewed journal providing scientific research for the evaluation and integration of complementary medicine into mainstream medical practice." "Integrative and Complementary Medicine" is a fancy way of saying quackery. Also, the video you linked to is on a channel run by a person describing himself as "a certified functional medic…
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If this Was discovered 10 years ago, I’m assuming it must be fairly limited in helping, or the results haven’t lasted or something?
The cynic in me assumes that it's because this is not a patentable drug. EDIT: MJF foundation is aware of it at least - https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... , but points out problems with the study. Further Googling quickly leads to the usual quackery about the magical properties of different supplements and vitamins. Hope this goes somewhere though.
Everyone bangs in about the medical industrial complex, and points to either herbs and vitamins, or more recently ivermectin, or hydroxychloroquine.
Everyone conveniently just rolls over the fact that steroids (also patent free) were rapidly identified by a massive research study in the UK, became standard of care, and saved hundreds of thousands of lives.
Is the pharma industry broken? Yes. Are there doctors who are conveniently leaving the cheap things on the shelf so a pharma company can profit off misery? Doctors are people too. In the most extreme form of this conspiracy thinking, apparently no doctors get or die from cancer. Just think on that for a second
This is everything and nothing all at once. Synucleinopathies are found in many neurological diseases. They even find it in Long COVID. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108014/ This is a marker for many diseases. They still have not found the trigger for Synucleinopathies, which I believe is a nutrient deficiency causing oxidative stress and zinc is at the top of my list. https://academic.oup.com/hmg/art…
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This sounds really interesting! Can you provide a link to more info?
"A 2022 study found that infants who died of SIDS exhibited significantly lower specific activity of butyrylcholinesterase, an enzyme involved in the brain's arousal pathway, shortly after birth. This can serve as a biomarker to identify infants with a potential autonomic cholinergic dysfunction and elevated risk for SIDS." https://en.wikipedia.org/wiki/SIDS
I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…
Published in the "Journal of Integrative and Complementary Medicine", "The leading peer-reviewed journal providing scientific research for the evaluation and integration of complementary medicine into mainstream medical practice." "Integrative and Complementary Medicine" is a fancy way of saying quackery. Also, the video you linked to is on a channel run by a person describing himself as "a certified functional medic…
Yes we should be cautious but no we should not dismiss. In fact I consider myself very fortunate for stumbling on this information as it may be very helpful for someone I love and I want to explore every possible way that can help.
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No way. About five years ago there was a quack-y study about reducing death in sepsis which called for high-dose vitamin C, thiamine and steroids. None of these are patent protected. The first study purported to show a 100% reduction in mortality. There were many RCTs done after this which did not bear out the effect, and it has now essentially been proven to be ineffective. it is possible to fund studies without ind…
Who actually thought that steroids help with an infection? Don't those usually make you more susceptible?
There is actually a good reason to think that steroids are beneficial in severe infections. This is because often in a severe infection/inflammation, a big portion of the damage is done by the inflammatory response.
Reading about the pathophysiology of influenza 13 years ago after H1N1, I came to this conclusion, and it was trialed, but good quality studies showed it to not be effective.
COVID has a slightly different pathophysiology and in COVID it works.
But yea, as a rule, it’s not a good idea to dose with steroids if sick
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>This is likely on the same level as horse dewormer for COVID You mean something that's demonstrated to have a statistically significant protective effect in a majority of studies but was attacked mercilessly by the pharma industry and the media they fund because they can't profit from a generic drug like that? https://c19ivm.org/meta.html
Looks great .. dive in (talk to your local professional epidemiologist) and it's a skewed collection of low N studies mixed in with studies in regions with large intestinal parasite issues. Does horse dewormer do anything significant for large populations in first world countries? No. ( Save for regions with a intestinal parasite problem ) Elsewhere it gets rid of a significant number of parasites, making people heal…
I just found out about Thiamine (vitamin B1) megadose therapy for Parkinson's: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762356/ Another study: https://pubmed.ncbi.nlm.nih.gov/26505466/ > Conclusions: Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesiz…