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Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

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Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#51

Post by firephonestival »

lazide wrote: post #17
jmalicki wrote: post #4

The article is extremely short, but comparing 2-4 OTC doses of diphenhydramine to a level of alcohol concentration above what constitutes a DUI in most places seems like an odd choice? Or is that just a matter of proof of concept, go for the big obvious demonstration first?

Having done that for awhile once? It basically is, and that is the typically OTC recommended dose.

Sure, but you should always check basic mg/kg numbers before you take a drug. Diphenhydramine can be hallucinogenic in high doses.

They also sell 1-gram extra-strength Tylenol pills OTC, but that's a very high dose for an average person. And what do you know, acetaminophen is the leading cause of acute liver failure in the US.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#52

Post by 0xdeadb00f »

Trouble_007 wrote: post #16

FYI: Antihistamines : https://psychonautwiki.org/wiki/Antihistamine Diphenhydramine : https://psychonautwiki.org/wiki/Diphenhydramine

One not mentioned on this page is dexchlorpheniramine. In my personal experience, exceeding the recommended dose and fighting the drowsiness effect leads to quite a pleasant high and mild aphrodisiac effect.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#53

Post by lazide »

firephonestival wrote: post #51
lazide wrote: post #17

Earlier quoted context omitted.

Having done that for awhile once? It basically is, and that is the typically OTC recommended dose.

Sure, but you should always check basic mg/kg numbers before you take a drug. Diphenhydramine can be hallucinogenic in high doses. They also sell 1-gram extra-strength Tylenol pills OTC, but that's a very high dose for an average person. And what do you know, acetaminophen is the leading cause of acute liver failure in the US.

What is your point exactly?

That typical OTC doses for a common antihistamine ARE probably equivalent in impairment to being legally drunk for most people is mine?

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#54

Post by the_only_law »

0xdeadb00f wrote: post #52
Trouble_007 wrote: post #16

FYI: Antihistamines : https://psychonautwiki.org/wiki/Antihistamine Diphenhydramine : https://psychonautwiki.org/wiki/Diphenhydramine

One not mentioned on this page is dexchlorpheniramine. In my personal experience, exceeding the recommended dose and fighting the drowsiness effect leads to quite a pleasant high and mild aphrodisiac effect.

That’s kinda interesting. I’ve only ever heard of DPH and Doxylamine (which I’ll on occasion use as a terrible sleep aid). I knew other antihistamines exist, but was never curious about their effects.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#55

Post by the_only_law »

sokoloff wrote: post #33
weaksauce wrote: post #30

Earlier quoted context omitted.

The founder of madd in america thinks they went too far though. https://www.washingtontimes.com/news/2002/aug/6/20020806-035... > Candy Lightner, MADD’s founder, says she disassociated herself from the movement in 1985 because she believed the organization was headed in the wrong direction. > “It has become far more neo-prohibitionist than I had ever wanted or envisioned,” said Mrs. Lightner, who founded MADD after h…

I would sooner drive after a couple beers with dinner than after taking Benadryl (diphenhydramine). That’s not because I think alcohol is safe to drive on.

I’ve used doxylamine (similar antihistamine) as a sleep aid and I wouldn’t trust myself to do much. It was hard just getting ready for work because of the brain fog the next morning.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#56

Post by Trouble_007 »

0xdeadb00f wrote: post #52
Trouble_007 wrote: post #16

FYI: Antihistamines : https://psychonautwiki.org/wiki/Antihistamine Diphenhydramine : https://psychonautwiki.org/wiki/Diphenhydramine

One not mentioned on this page is dexchlorpheniramine. In my personal experience, exceeding the recommended dose and fighting the drowsiness effect leads to quite a pleasant high and mild aphrodisiac effect.

>One not mentioned on this page is dexchlorpheniramine. 

  Yes, I'm afraid the site is not comprehensive, and a bare-bones entry at wikipedia;
Dexchlorpheniramine : https://en.wikipedia.org/wiki/Dexchlorpheniramine

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#57

Post by ta988 »

retrac wrote: post #13
etaioinshrdlu wrote: post #6

50mg diphenhydramine is quite a bit! Anyone who has ever taken that amount for sleep effects will tell you so.

It is, but 25 - 50 mg every 4 - 6 hours, with no more than 200 mg over 24 hours, is also the instructions on the OTC bottle I have. I made that mistake once in university. Took two capsules for a moderate skin reaction and slept the entire afternoon away. Fortunately I was at home! Just willing myself to get up long enough to disrobe and turn the lights off was excruciating.

Look on Reddit some people are taking much much more recreationally and the usage reports are pretty daunting.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#58

Post by hammock »

danachow wrote: post #49
hammock wrote: post #19

Earlier quoted context omitted.

> Fluticasone A corticosteroid, it has awful side effects as well

Administered nasally it has very poor systemic bioavailability.

I thought so at first. My personal experience was different though.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#59

Post by bradknowles »

danachow wrote: post #50
988747 wrote: post #21

Earlier quoted context omitted.

Well, you can give non-alcoholic beer to the subject telling them it is a real thing. Or make them a cocktail, such as Mojito, just a virgin one. Or the opposite: give them a soda secretly spiced with vodka. The possibilities are endless. But the problem is: people usually are familiar with how being drunk feels (and 0.1% BAC is pretty drunk), so it's almost impossible to hide the fact from them. So I guess "placebo…

> But the problem is: people usually are familiar with how being drunk feels The problem is people know how alcohol tastes. Have you ever had a non-alcoholic beer?

There are alcoholic beers that taste as bad or worse as the non-alcoholic ones.

And there are alcoholic drinks that taste like they have no alcohol in them at all. Or drinks where you cannot tell if they have any alcohol in them.

There are ways to make these things blinded.

Re: Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

#60

Post by danachow »

bradknowles wrote: post #59
danachow wrote: post #50

Earlier quoted context omitted.

> But the problem is: people usually are familiar with how being drunk feels The problem is people know how alcohol tastes. Have you ever had a non-alcoholic beer?

There are alcoholic beers that taste as bad or worse as the non-alcoholic ones. And there are alcoholic drinks that taste like they have no alcohol in them at all. Or drinks where you cannot tell if they have any alcohol in them. There are ways to make these things blinded.

> Or drinks where you cannot tell if they have any alcohol in them.

Proving this for a sample is pretty much impossible because you’re simply masking it and the sensory performance of humans is highly variable. You can get some imperfect approximation of blinding but it will be a compromise.

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