Effects of fexofenadine, diphenhydramine, and alcohol on driving performance

Post by volkl48 » Sat, Apr 30, 2022, 10:45 PM UTC

stordoff wrote: post #31

Is 60mg a typical dose of fexofenadine? I'm only familiar with it as 180mg tablets (I was initially prescribed 180mg twice daily for dermatographic urticaria, and currently take 360mg twice daily).

Post by tom_ » Sat, Apr 30, 2022, 10:55 PM UTC

hammock wrote: post #35

0xB31B1B wrote: post #34

Earlier quoted context omitted.

Shooting a gun into a crowd and not hitting anyone is also a "victimless crime", that doesn't mean it isn't high risk behavior that should be discouraged. The reality is that the large majority of drunk drivers are chronic drunks and drunk driving rules are pretty effective at taking them off the road.

>the large majority of drunk drivers are chronic drunks and drunk driving rules are pretty effective at taking them off the road. That's a good point. Aren't you now arguing though that the vast majority of drinkers, who are not chronic drunks, be punished for the actions of a few?

Post by runnerup » Sat, Apr 30, 2022, 11:09 PM UTC

sjmm1989 wrote: post #40

runnerup wrote: post #7

Earlier quoted context omitted.

2 doses of diphenhydramine can have very noticeable and profound effects on many people, 50mg total isn't a light dose by any metric. That seems fine as a comparison to 0.1% BAC. But 60mg Fexofenadine makes no sense to me in comparison. It's usually 180mg in a single pill.

Hate to break it to you, but 50mg is pretty much a common dosage for most people taking Diphen. At least where I lived over the past few decades... This is mostly due to the effect of 'if 1 pill is almost enough to do the job, then 2 pills should be adequate'. You see this a lot with people who take Tylenol and/or Advil. Tylenol overdoses are more common because of the frequency of acetaminophens use in other medicat…

Post by chillingeffect » Sat, Apr 30, 2022, 11:44 PM UTC

tyrfing wrote: post #2

2nd gen antihistamines (Fexofenadine, Cetirizine, Loratidine) are definitely what you want for allergies. 1st gen like Benadryl/Diphenydramine have awful side effects. I highly recommend nasal sprays like Fluticasone as well, available OTC in the US these days and amazing stuff.

Post by danachow » Sun, May 01, 2022, 1:26 AM UTC

988747 wrote: post #21

mberning wrote: post #18

I didn’t see it in the abstract but how are the alcohol and placebo administered? If they were ingested the participant surely knew they got alcohol or a placebo. And I assume that may have some impact on their performance aside from possibly being intoxicated. I suppose all 4 could be IV administered, but it doesn’t sound like that.

Well, you can give non-alcoholic beer to the subject telling them it is a real thing. Or make them a cocktail, such as Mojito, just a virgin one. Or the opposite: give them a soda secretly spiced with vodka. The possibilities are endless. But the problem is: people usually are familiar with how being drunk feels (and 0.1% BAC is pretty drunk), so it's almost impossible to hide the fact from them. So I guess "placebo…