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Progress of anti-aging therapies by clinical trial stage

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Re: Progress of anti-aging therapies by clinical trial stage

#51

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

> most people who are chronically stressed will generally never be able to obtain relief

This really stood out to me. If this is how you feel, I strongly recommend trying out meditation. I at one point in my studies while in college felt the same, and it really is night versus day in being able to experience a life without constant stress/anxiety.

> The same for proper sleep. Its not just about 6-8 hours, its about quality. If you aren't getting quality sleep, most people don't have a solution.

Stress/anxiety from above is generally the most common cause of poor sleep. Fixing that will give quality sleep for the majority of people. The next thing to try is to check with your doctor whether you have sleep apnea as that's probably the second most common trigger. For some, sleep apnea is treatable with better sleeping posture and for others it will require more active work to resolve. A note that obesity is the most common cause of sleep apnea. The third most common cause is likely some kind of thyroid condition. More than that is probably going to be a case by case basis where you'll have to individually look at your genetic profile through something like SNPedia (https://www.snpedia.com/index.php/SNPedia) to try and pinpoint your underlying issue. Usually though, the first three things will cover the vast majority of people looking for better sleep.

> In other words the goal is to trigger the body to begin consuming/recycling dead cells and other cellular waste; however, this typically isn't triggered by time restricted eating, but requires longer periods of fasting (usually kicking in around after 20-24 hours of fasting

For most normal people, it's unrealistic to be able to do day fasts. That's why the 8/16 method is so popular. You'll still see benefits as you are incorrect that, there has to be a strict limit of precisely 20 hours to get beneficial effects. Autophagy like any other biological process in the body is a series of continuous interlinking upregulating and downregulating mechanisms that ensure homeostasis. Autophagy is always happening. It's just that the longer you fast, the more your body gets tilted towards consuming/recycling until of course you end up in starvation which is effectively just extreme autophagy.

> Finally "a complete diet", not only is there no general consensus what that is, you generally can't even have a conversation about diet without triggering a flame war.

A complete diet to the best of our knowledge, consists of getting enough macronutrients like protein, lipids, and carbohydrates in addition to an immense number of different micronutrients that while seemingly daunting in size are actually relatively easy to get enough of as long as you eat a diverse mixture of different foods. If that answer doesn't satisfy you, there have been many different studies and current ongoing ones as well to try and pinpoint all the essential trace nutrients the human body needs to survive. From the ones that we've been able to gather over the years, if you were to solely supplement yourself based on those listed, you'd probably be fine. Though it's likely that there would be some things missing.

Re: Progress of anti-aging therapies by clinical trial stage

#52

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

"In other words the goal is to trigger the body to begin consuming/recycling dead cells and other cellular waste; however, this typically isn't triggered by time restricted eating, but requires longer periods of fasting (usually kicking in around after 20-24 hours of fasting)."

I can't comment on how long it takes to achieve autophagy - I am happy to stipulate that you are correct.

However, digestion is a very all-encompassing, rigorous and expensive activity for your body. If we believe that there are more "cleanup" mechanisms than just autophagy, it's not much of a reach to suggest that we engage in extra digestion at the expense of these maintenance tasks.

Re: Progress of anti-aging therapies by clinical trial stage

#53

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

Agreed. If you want to add to it, there's evidence that sauna and donating blood have benefits as well.

https://www.ncbi.nlm.nih.gov/pubmed/25705824

https://www.ncbi.nlm.nih.gov/pubmed/26098293

Re: Progress of anti-aging therapies by clinical trial stage

#54

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

> I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger.

If you have any ready-researched and outlined sources or links for this, please post them here for reference. I know that we all can google, but I think linking here will help a lot of people, me included. HN articles are sometimes used as an online notepad of sorts, a repository of well researched and compiled information with built-in peer review from (hopefully, since they are on HN) somewhat competent even if amateur internet researchers.

Re: Progress of anti-aging therapies by clinical trial stage

#55

Earlier quoted context omitted.

>Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training Yes, but the problem is this is such a broad brush stroke. For example, most people who are chronically stressed will generally never be able to obtain relief. There is a common joke about abs being made in the kitchen not in the wei…

> most people who are chronically stressed will generally never be able to obtain relief This really stood out to me. If this is how you feel, I strongly recommend trying out meditation. I at one point in my studies while in college felt the same, and it really is night versus day in being able to experience a life without constant stress/anxiety. > The same for proper sleep. Its not just about 6-8 hours, its about q…

>This really stood out to me. If this is how you feel, I strongly recommend trying out meditation. I at one point in my studies while in college felt the same

I run about 7-10 miles a day and mediate, and no I am not talking about me, I am talking about the effects of cortisol and chronic stress generally. And not to take away from the stress you felt in your studies, as I say stress is cortisol and the effects are the same no matter the trigger, but in the scheme of life stress in studies is very low. Consider people who have been through traumatic events war, rape, homelessness, kidnappings, murder of a loved one, the death of a child, etc... ]

>You'll still see benefits as you are incorrect that, there has to be a strict limit of precisely 20 hours to get beneficial effects.

I never said there are no beneficial effects of IF, caloric restriction is good for most people and IF helps that. However, I think you should read the actual Nobel Prize winner's papers and research before you say I am incorrect, or consider you are saying the Nobel Prize winner is incorrect, because I was quoting him.

>It's just that the longer you fast, the more your body gets tilted towards consuming/recycling until of course you end up in starvation.

No autophagy has a peak and it is far short of dying of starvation. Again read the work.

Re: Progress of anti-aging therapies by clinical trial stage

#56

Proper sleep, a complete diet, minimizing stress (I'm personally biased towards meditation), intermittent fasting, and vigorous cardiovascular exercise complemented by strength training will by far have the most impact in maximizing your natural lifespan. You shouldn't look at doing anything else until you've at minimum mastered all of the listed items above. Nothing else will have as much outsized impact.

This post is poorly researched or misguided relative to the topic at hand.

We are discussing drugs(or other systemic measures or therapies) that make people younger. The only thing that you can manage to do if you do all those things you listed perfectly is to come close to your theoretical maximum lifespan that is already preset in your biology/genetics. What we are trying to do with these drugs is to increase that biological span, the base span that you are currently always limited at, regardless of how many broccoli you eat or how many steps you make each day. Those are not the same endeavors, they don't work in the same way (although sometimes they will overlap of course).

Please see this quote from Aubrey de Grey: https://www.youtube.com/watch?v=fPyObli0ezA

It is not enough to just recommend people to have a good lifestyle. That is a plus, but that will not get humanity to regular 100+ of healthy life years. We need actual new biological or genetic technology to do this.

Re: Progress of anti-aging therapies by clinical trial stage

#57
post #22
post #6

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

That sounds cheap compared to the cost of old-age healthcare. For comparison, Alzheimer’s care homes cost ~£1000/week in the UK.

A lot of preventative care just delays old-age care rather than avoiding it entirely.

I remember a professor in law school saying that during the big tobacco trials, someone mentioned that people dying younger from smoking meant lower healthcare costs overall, because the major predictor of healthcare costs is age. Basically everyone dies, and the older you are when you die, the more expensive it will be.

Obviously that's not a good reason to die early, but preventative care is mostly good for quality of life, rather than from a financial perspective.

Re: Progress of anti-aging therapies by clinical trial stage

#60

Earlier quoted context omitted.

HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them. So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back. Also, there are many types of tumors that have HGH receptors, and HGH has an ev…

Yes the tumors part was always what scared me about it and why i would not do it again. Its the first time i hear about hgh being able to stop your own production its not something ive found researching the downsides. Its Well know for steroids though.

I don't care how young HGH will make me feel if I'm sacrificing longevity because of increased cancer risk. Cancer is the #1 enemy of longevity.
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