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Longevity Linked to Proteins That Calm Overexcited Neurons

quantamagazine.org

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Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#51

Post by keenmaster »

bitL wrote: post #46
keenmaster wrote: post #23

Earlier quoted context omitted.

There’s a theory that longevity is lower in men because they need to be stronger in order to survive in a conflict. It’s a trade off. Physical strength is the result of growth, but some of the same pathways for increased growth are also theorized to be the root cause of aging. Note that this is independent of strength training; it’s the ability to get stronger, rather than actually getting stronger (among other relat…

More muscles are correlated with lower incidence of cancer (and inflammation), so that goes against strength preference being a reason of aging.

Scientists are finding that aging is a discrete disease that catalyzes other secondary diseases, like cancer and dementia. They are also finding that it is highly likely that men’s cellular aging is slightly accelerated compared to women, albeit with the trade off described above. The anti-inflammatory benefits of muscle are overwhelmed by the avalanche of diseases caused by aging. If you’re 80 years old and you use drugs to stave off one disease, you’re likely to die from another disease soon thereafter. It’s like playing wack-a-mole, because we’re not addressing the primary disease: aging. That may change soon since more research is being done into aging as a disease.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#53

Post by keenmaster »

redsymbol wrote: post #38
rpmisms wrote: post #14

Does this relate in any way to the anti-aging drug cocktail that we saw a few months ago? IIRC that one related to genetic aging markers, and stress can affect mitosis. It seems like immortality has a lot of building blocks, and the research isn't far enough to combine them yet.

Anyone have a link to that? Sounds interesting.

You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8

Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day:

- Resveratrol – 1g in the morning (this is synergistic with NMN)

- Nicotinamide Mononucleotide (NMN) – 1g in the morning

- Metformin (prescription drug) – 1g in the evening – except on days when exercising, since metformin reduces muscle growth after exercising

(As an aside, he also engages in intermittent fasting, to reduce his total feeding hours. There’s a theory that intermittent fasting triggers a beneficial stress response whereby your body becomes more “efficient” in a way that prolongs life. Intermittent fasting has been shown to prolong lifespan in mice. Interestingly, resveratrol is expressed in plants as a defense mechanism akin to what intermittent fasting does in humans, and that’s one of the supplements that Sinclair recommends.)

Sinclair is very careful not to recommend that cocktail for anyone, since anti-aging research is still very preliminary. The relevant human trials are underway. However, NMN in particular has had astonishing effects on mice. Mice that took NMN lived significantly longer than other mice. Old mice that took it ran for so long that the measuring device on their running wheel timed out, because they weren’t expected to ever run that long.

In old age, the NMN mice were conspicuously stronger, had more hair, saw better, and were more mentally intact. In short, NMN might reverse the underlying epigenetic causes of aging. Sinclair subscribes to the information theory of aging, where, over time, your epigenome accumulates damage and errors, and protective mechanisms die out. It’s like scratches on an overplayed analog vinyl disc which slowly declines in function and eventually stops playing altogether. You lose a majority of your NAD+ as you get older (NAD+ is fed by NMN), which is problematic because NAD+ feeds biological mechanisms which mitigate informational damage. That’s why supplementing with NMN is theorized to have anti-aging effects.

Sinclair wrote a great book synthesizing aging research if you want to read more about it. https://www.amazon.com/dp/1501191977/ref=cm_sw_em_r_mt_awdo_...

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#54

Post by dang »

juliendorra wrote: post #22
alexis_fr wrote: post #4

Earlier quoted context omitted.

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

I know that your points are standard masculinist talking points and I most probably won’t change your perspective. As I understand it, you seem to point the blame for men relatively shorter lifespan (which in fact have consistently grow over the last decades in OCDE countries, except in the US) toward “more attention to women’s issues”. Of course every single bit of attention to women’s issues have been a very long h…

Please don't take HN threads further into gender flamewar. Last thing we need here.

https://news.ycombinator.com/newsguidelines.html

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#55

Post by eyeball »

keenmaster wrote: post #53
redsymbol wrote: post #38

Earlier quoted context omitted.

Anyone have a link to that? Sounds interesting.

You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8 Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day: - Resveratrol – 1g in the morning (this is synergistic with NMN) - Nicotinamide Mononucleotide (NMN) – 1g in the morning - Metformin (prescription drug) – 1g i…

hopefully it doesn't turn out like the book of that sleep guy, matthew walker

https://guzey.com/books/why-we-sleep/

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#56

Post by moh_maya »

keenmaster wrote: post #53
redsymbol wrote: post #38

Earlier quoted context omitted.

Anyone have a link to that? Sounds interesting.

You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8 Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day: - Resveratrol – 1g in the morning (this is synergistic with NMN) - Nicotinamide Mononucleotide (NMN) – 1g in the morning - Metformin (prescription drug) – 1g i…

Re reservatol:

The jury is out in terms of its efficacy, or lack thereof. [1,2]

[1] https://www.health.harvard.edu/blog/resveratrol-the-hype-con...

[2] https://www.health.harvard.edu/blog/diet-rich-resveratrol-of...

Re. David Sinclair [3]:

"Despite his enthusiasm, published scientific research has not yet demonstrated the molecule works in humans as it does in mice. Sinclair, however, has a considerable financial stake in his claims being proven correct, and has lent his scientific prowess to commercializing possible life extension products such as molecules known as “NAD boosters.”

His financial interests include being listed as an inventor on a patent licensed to Elysium Health, a supplement company that sells a NAD booster in pills for $60 a bottle. He’s also an investor in InsideTracker, the company that he says measured his age."

[3] https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#57

Post by keenmaster »

moh_maya wrote: post #56
keenmaster wrote: post #53

Earlier quoted context omitted.

You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8 Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day: - Resveratrol – 1g in the morning (this is synergistic with NMN) - Nicotinamide Mononucleotide (NMN) – 1g in the morning - Metformin (prescription drug) – 1g i…

Re reservatol: The jury is out in terms of its efficacy, or lack thereof. [1,2] [1] https://www.health.harvard.edu/blog/resveratrol-the-hype-con... [2] https://www.health.harvard.edu/blog/diet-rich-resveratrol-of... Re. David Sinclair [3]: "Despite his enthusiasm, published scientific research has not yet demonstrated the molecule works in humans as it does in mice. Sinclair, however, has a considerable financial sta…

Yep, resveratrol on its own doesn’t seem to do much, which is puzzling given its effect on mice. That’s why I added Sinclair’s claim that it is a synergistic part of his drug cocktail. Let’s hope NMN is different. As for Elysium, Sinclair is not affiliated with them and he said he doesn’t make any money off of supplement sales.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#58

Post by keenmaster »

eyeball wrote: post #55
keenmaster wrote: post #53

Earlier quoted context omitted.

You should watch Joe Rogan speak with David Sinclair, who researches aging at Harvard, about the latest developments in his field https://youtu.be/ZGLL77wYxe8 Aside from multivitamins and idiosyncratic drugs, Sinclair takes the following supplements every day: - Resveratrol – 1g in the morning (this is synergistic with NMN) - Nicotinamide Mononucleotide (NMN) – 1g in the morning - Metformin (prescription drug) – 1g i…

hopefully it doesn't turn out like the book of that sleep guy, matthew walker https://guzey.com/books/why-we-sleep/

Walker seems to have made some claims without empirical backing. Sinclair on the other hand refers to miracle research in mice and says that they might or might not translate into humans. However, he does explain, at length, how it may work to extend longevity in humans just like it does in mice.

He also gave the aforementioned drug cocktail to his elderly dad and said it seems to have rejuvenated him. His dad is hiking all around Australia, just like he did as a young man. I paid little attention to that particular claim since it is an n=1 anecdote.

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