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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#491

Post by gavinray »

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

I've used Retatrutide and wasn't that impressed

I used 5mg/wk

(Have used Semaglutide, Tirzepatide, and Retatrutide. For Sema/Tirz, I've had both RX and grey market.)

Re: Ozempic shows anti-aging effects in trial

#492

Post by siva7 »

ykonstant wrote: post #411
toomuchtodo wrote: post #326

Earlier quoted context omitted.

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(

Get it simply over other legal channels instead of fighting with the stupidity of the local medical system.

Re: Ozempic shows anti-aging effects in trial

#493

Post by Fargren »

anal_reactor wrote: post #407
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I think Ozempic is just a symbol of what modern life looks like. Obesity is a problem that 100% could be solved with a cultural shift (see Japan), but instead we decide to use medicine. It's like, humanity at large grew such big brains because there was evolutionary pressure to be intelligent, but now we're using intelligence to remove that pressure. Which would make sense if we redirected that intelligence to someth…

The way Japan "solves" obesity is quite cruel on those it does not work for. Overweight natives are not treated kindly. I think creating a medicine to make this easier is a moral good, and a sign of kindness and intelligence. Hopefully the aliens also agree.

Re: Ozempic shows anti-aging effects in trial

#494

Post by ajb »

WithinReason wrote: post #435
glp1guide wrote: post #349

Earlier quoted context omitted.

> If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense... It turns out enterprising chemists and pharmacists are capable of reverse engineering. I don't think it's that hard to figure out how someone might do it -- imagine having to reverse engineer food you've received, given many samples. Imagine some of those samples might have "fallen off the back of a truck". > That being…

Wikipedia has the exact formula: https://en.wikipedia.org/wiki/Retatrutide

Yes, chemists don't need to reverse engineer that (although they can) because it will be in the patent. I'm not sure if the production process is though.

Re: Ozempic shows anti-aging effects in trial

#495

Post by wisty »

benchly wrote: post #459
strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great, how come our bodies don't just... While I agree with your sentiment, your argument here assumes the human body always makes intelligent decisions for itself. My obstructive sleep apnea would like a word. After it's done choking me awake, of course. The body is a marvelous machine, but it is far from a perfect or intelligent design. We are lucky to have what we have, but expect operating mist…

Evolution should make intelligent choices for us but there's thousands years where a few extra pounds meant surviving a famine.

Also I bet it will kill a few people with eating disorders.

As long as you're in a 1st world country and have a BMI over ... maybe 25 (and aren't on steroids so you're both anorexic and overweight at the same time) I'd guess you're dodging a lot of the most obvious risks.

Re: Ozempic shows anti-aging effects in trial

#496

Post by theshackleford »

gryn wrote: post #37
NoMoreNicksLeft wrote: post #27

Earlier quoted context omitted.

>My opinion is to wait long enough to validate there are no long term harms, What's your threshold on that? How many years is "long enough"? Trying to calibrate my own sense of risk.

I'm a late adopter to most things. my estimate would bigger than others and I would put it at 30-50years. I take smoking as a cautionary tale, in the beginning it was pushed as not just a recreational thing but a healthy activity that bring benefits with papers published to sing praises about it. my parents were even nudged by their teachers/doctors/etc when they were young to try smoking. now we all know that smokin…

> with papers published to sing praises about it

Links to these papers? I’ve always been curious because I’ve seen this claim many times, especially on HN but no one has ever managed to actually provide a source on one.

Re: Ozempic shows anti-aging effects in trial

#497

Post by astrange »

ggsp wrote: post #429
astrange wrote: post #369

Earlier quoted context omitted.

Fun fact: eating a bunch of black pepper cancels that out.

[flagged]

I meant it cancels out the effect of THC. Which is handy if you've taken an edible and are getting tired of it. But yes, that too.

Re: Ozempic shows anti-aging effects in trial

#498

Post by radu_floricica »

simmerup wrote: post #433
radu_floricica wrote: post #390

Earlier quoted context omitted.

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Statins change some peoples personalities https://www.bbc.co.uk/future/article/20200108-the-medication...

I don't think we really need to worry about rare and very rare side-effects. Or if we do, it'd be fair to also start worrying about all of them equally, but that would mean not taking any drugs ever.

Re: Ozempic shows anti-aging effects in trial

#499

Post by mghfreud »

ykonstant wrote: post #411
toomuchtodo wrote: post #326

Earlier quoted context omitted.

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(

Visit Turkey for a couple weeks. Rules are the same, but behavior is the opposite. Weekly dose of 1mg is sold over the counter for around 150$.

Re: Ozempic shows anti-aging effects in trial

#500

Post by redwood »

glp1guide wrote: post #283
fortran77 wrote: post #274

Earlier quoted context omitted.

I think that, just like with stomach reduction surgery, people are going to find a way to overeat and gain weight while taking Ozempic too.

Nope, because the change is actually in the brain . https://glp1.guide/content/research-on-glp1-signaling-in-the... https://glp1.guide/content/research-suggesting-glp1-is-a-bra... https://glp1.guide/content/are-glp1s-primarily-brain-drugs/ This is the killer feature of Semaglutide and GLP1 Receptor Agonists widely. They were originally commonly thought about as digestion-slowing, and while that is part of it, the rea…

Is glp1guide a neutral source? Honest question
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