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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#281

Post by glp1guide »

godshatter wrote: post #112
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly. There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run. We also don't know what the long term side effects of it will be, if any. I don't find…

> I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly.

This isn't true

https://glp1.guide/content/do-people-regain-all-the-weight-l...

The rest of the incorrect points other people have basically covered, so won't repeat.

Is teaching the discipline lesson worth the shorter life people would live without this medication? Maybe we could find another way to teach people discipline that doesn't maintain a threat to their health?

> I don't find any of that unreasonable to me. I'm saying this as a type-2 diabetic who could stand to lose a lot of weight.

Gonna be incredibly blunt, but talk to your doctor and get on GLP1s. Take a low dose if you want.

GLP1s are incredibly well researched and effective. Imagine dying of a heart attack early because you refused to properly research effective, low-risk medication that is being used by millions and recommended by professional organizations and doctors widely. Real Steve Jobs energy.

Re: Ozempic shows anti-aging effects in trial

#282

Post by glp1guide »

m463 wrote: post #277
glp1guide wrote: post #269

Earlier quoted context omitted.

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

> We think obesity is basically going to be gone in I wonder if this is for wealthy people (...who might be the target market - being overweight might be a disease of affluence)

Nope! It won't be, because capitalism.

In 2026, patent protections that lapse are going to cause a tidal wave:

https://glp1.guide/content/novo-nordisk-patent-protections-l...

For context, the previous calculus was:

https://glp1.guide/content/patent-expirations-for-glp1-recep...

(~2033 for the US)

Theoretically, the tidal wave of generic Semaglutide wouldn't hit the US or EU due to patent protections there... But see the aforementioned note about capitalism.

Note that there is already generic Liraglutide as well:

https://glp1.guide/content/another-generic-liraglutide-launc...

Tirzepatide (Mounjaro/Zepbound) > Semaglutide (Ozempic/Wegovy/Rybelsus) > Liraglutide

But having any of these available is a step change.

> (...who might be the target market - being overweight might be a disease of affluence)

This might be true on the margin but is mostly untrue these days. The lack of access to healthy unprocessed food and the free time to exercise are becoming increasingly problems for those who are NOT wealthy.

Re: Ozempic shows anti-aging effects in trial

#283

Post by glp1guide »

fortran77 wrote: post #274
glp1guide wrote: post #269

Earlier quoted context omitted.

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

I think that, just like with stomach reduction surgery, people are going to find a way to overeat and gain weight while taking Ozempic too.

Nope, because the change is actually in the brain.

https://glp1.guide/content/research-on-glp1-signaling-in-the...

https://glp1.guide/content/research-suggesting-glp1-is-a-bra...

https://glp1.guide/content/are-glp1s-primarily-brain-drugs/

This is the killer feature of Semaglutide and GLP1 Receptor Agonists widely. They were originally commonly thought about as digestion-slowing, and while that is part of it, the real change is that it's a brain drug.

Oh also, on whether people gain back the weight:

https://glp1.guide/content/do-people-regain-all-the-weight-l...

tl;dr - most people (i.e. over 50%) do not.

Re: Ozempic shows anti-aging effects in trial

#284

Post by loeg »

fortran77 wrote: post #274
glp1guide wrote: post #269

Earlier quoted context omitted.

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

I think that, just like with stomach reduction surgery, people are going to find a way to overeat and gain weight while taking Ozempic too.

Uh, so, first, I'll say that bariatric surgery is largely a successful (if extremely invasive) intervention. It is not the case that people who do that surgery somehow compensate eat back to the same level -- on average, they don't. And second, the GLP-1s just massively reduce the urge to snack/eat. I'm sure they are less effective for some people than others, but on the whole they are miraculously effective for the population that overate habitually (the obese).

Re: Ozempic shows anti-aging effects in trial

#285

Post by homefree »

rockemsockem wrote: post #205
throwawaylaptop wrote: post #185

Earlier quoted context omitted.

[flagged]

I find that almost all doctors give useless advice. On multiple occasions I've been advised that there was nothing wrong but they can run a scan "if I insist" and then bam, the exact problem I expected shows up clear as day. They're morons for the most part.

It’s like any other field, most suck and it requires effort to find the smart ones.

Re: Ozempic shows anti-aging effects in trial

#286

Post by glp1guide »

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water:

https://glp1.guide/content/a-new-glp1-retatrutide/

Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense.

[EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it or do even take GLP1s in general. The point is that we have a preview of anecdata from people (with obviously high risk tolerance) taking this drug.

Re: Ozempic shows anti-aging effects in trial

#287

Post by loeg »

matwood wrote: post #68
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I've heard this as well, but (anecdotally) they haven't reduced my interest in alcohol at all.

Re: Ozempic shows anti-aging effects in trial

#288

Post by slavik81 »

nosignono wrote: post #178
garbawarb wrote: post #177

Earlier quoted context omitted.

I wonder how it compares to Adderall.

Adderall produces a very, very different experience and is prescribed to address a very, very different root cause.

However, amphetamines such as Adderall were also sometimes prescribed for weight loss. I'm surprised it was done so rarely before Ozempic was a thing. They were quite effective.

Re: Ozempic shows anti-aging effects in trial

#289

Post by homefree »

nradov wrote: post #255
42772827 wrote: post #241

Earlier quoted context omitted.

The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar." You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

Obviously it’s not much easier or the drug wouldn’t be so valuable.

People make such a moral crusade of this - the drug works, people will take it. Behavior modification works in theory and fails for most in practice. Even for those that can make it work usually don’t hold out indefinitely.

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