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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#481

Post by tedmiston »

SubiculumCode wrote: post #65
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

And this morning, I cut another hole in my belt. Turns out, losing weight and being thin was never about willpower or laziness in the face of absolute food abundance. It was mostly about whether a person was born lucky enough to have a moderate appetite, or was born burdened by exaggerated appetite. The underlying issue is physiological food cravings, not some personal failing or lack of willpower, and GLP-1 absolute…

[dead]

Re: What Ozempic does to the gut-brain axis

#482

Post by ElProlactin »

wpm wrote: post #476
ElProlactin wrote: post #230

Earlier quoted context omitted.

> People take depression meds, blood pressure meds, all kinds of meds for their whole life. And a lot of these medications have side effects that can affect quality of life negatively in other ways. That doesn't mean they're not helpful, or shouldn't be taken. But the "no free lunch" rule usually applies, sometimes to a noticeable degree.

OK, so is the point being made that "drugs have side effects"? Wow. I had no idea. Come on, why is it that whenever GLP-1s come up on this site, the comments are filled with people helpfully pointing out this fact as if no one knows it already?

> ...the comments are filled with people helpfully pointing out this fact as if no one knows it already?

First, I don't personally have it out for GLP-1s specifically.

Second, here's the thing about side effects: there are a good number of examples across multiple categories of drugs showing that some people experience side effects doctors and pharmaceutical companies have insisted aren't real or are exceedingly rare, with evidence later showing this not to be the case.

For instance, there is a growing body of evidence that a subset of people who take SSRIs experience life-altering sexual dysfunction that persists long after the SSRIs are discontinued. Up until fairly recently, that this was happening at all was basically dismissed by all but a small number of practitioners. Now, there's a name for this and even some warning labels.

In the US, which is only one of two developed countries in the world that allows pharma companies to advertise directly to consumers, there are huge incentives to minimize side effect profiles and even to bias clinical trials so that benefits are exaggerated and downsides are underestimated.

https://jamanetwork.com/journals/jama/fullarticle/198809

Re: What Ozempic does to the gut-brain axis

#483

Post by wpm »

faangguyindia wrote: post #151
phil21 wrote: post #122

Earlier quoted context omitted.

Who is lying? I was fat because I ate too much. Why I ate too much is uninteresting to me. I also don’t have some moral hang up over it. Give me that easy button all day long so I can focus on shit in my life that actually matters. If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care?

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care? Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? if there is no resistance, simply prescribin…

> if there is no resistance, simply prescribing GLPs to average person may become a new normal.

so what?

Re: What Ozempic does to the gut-brain axis

#484

Post by cjbgkagh »

Scalestein wrote: post #436
cjbgkagh wrote: post #432

Earlier quoted context omitted.

I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modaf…

Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically. Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.

That reaction could very much be dose dependent. I think those in most need of the effect start out very hypersensitive to it and that reaction could easily obscure any benefits.

I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants.

My overall theory is that a combination of anxiety disorders (genetic inability to ameliorate stress) pushes me into a Sympathetic state and keeps me there to the point that cytokines (or some undiscovered small molecule) are created by the immune system to knock me out of that state as a backup to other mechanisms that have stopped working. So I studied some psychopharmacology to design a drug combo that wouldn’t override the autonomic state so I could both work with my natural rhythms (using weaker ligands) and increase the magnitude of the swings so that I could spend enough time in the Parasympathetic state to obviate the need for the immune system backup. I take a lower dose of Modafinil (100mg started and stayed at this dose no apparent tolerance build) and am genetically very sensitive to caffeine so that and one coffee is enough to get me amped for the entire day, but I need amitryptiline to bring me back down to sleep (started as 25mg and many years later I’m at 125mg due to increasing tolerance). I do want to bring down my reliance on amitryptiline but I’m working crazy hours and figure I can wait to titrate down my dose later. I’ve been at this same dose for a year now so it’s at least not getting any worse).

Re: What Ozempic does to the gut-brain axis

#485

Post by sublinear »

nullc wrote: post #410
sublinear wrote: post #199

Earlier quoted context omitted.

I had a similar experience bringing down my A1C. People talk a lot about meat, but not enough about dairy. My prayers were answered at the altars of feta, greek yogurt, half and half, butter, cottage cheese, etc. They made salads not suck. They opened up a ton of lower carb dessert options. My gut health improved. All of my health improved. I no longer treat these humble foods as optional extras. They perfectly fill…

How'd your LDL?

Cholesterol levels are normal. I did mention salads, but fair enough, I forgot to mention how important fiber is. Some people look to these comments for advice.

I'm not advocating for a crazy diet. I'm just saying people ignore the basics and assume that healthy food has to be miserable. Small changes add up and make a big impact.

Re: What Ozempic does to the gut-brain axis

#486

Post by treis »

faangguyindia wrote: post #332
toasterlovin wrote: post #327

Earlier quoted context omitted.

You’re like a guy who’s confused why drug addicts don’t just try not taking drugs.

I've helped many people lose weight, become jacked, and go from underweight to a healthy weight. I regularly hear from overweight and obese people who come to me, “I’m genetically predisposed to being fat.” Yet after a few months, we often make significant progress. Many of them have also tried “deficit dieting,” and it didn’t work for them. But when I looked more deeply into their methods, I found they had calculate…

Pretty much everyone can make significant progress in a few months. That’s not the problem being solved.

Re: What Ozempic does to the gut-brain axis

#487

Post by grey-area »

serf wrote: post #473
rnewme wrote: post #363

Earlier quoted context omitted.

Eating disorders are mental health condition. Just because there are a lot of visible "false" cases, it doesn't mean that someone else is not living it for real. Your comment is insensitive

these types of (modern) eating disorders are a product of our current market, and I think that blaming humans for eating wrong due to 'food noise' when many shelves have little else to offer is insensitive victim blaming. the perpetrators are the people selling poison under false auspices. we're not blaming people with pica for eating drywall. We're blaming profiteers for shoveling garbage into the mouth of anyone wi…

> Many shelves have little else to offer

Go into any western supermarket and there are massive aisles of fruit and veg, along with various types of protein.

None of these eating disorders are new. If anything it is far easier to be healthy now.

Re: What Ozempic does to the gut-brain axis

#488

Post by anon84873628 »

photon_lines wrote: post #479
frgturpwd wrote: post #370

Earlier quoted context omitted.

And what's the underlying issue, exactly?

Eating ultra processed foods with added sugar / loads of calories. A huge reason why they're so destructive is because they lack fibre (which keep our microbiomes healthy) and lack compounds which are good for us. Try keeping weight on while eating minimally-processed food that is more vegan in nature: the amount you'll have to consume to keep the weight on is significant. When you start this diet, you won't like it…

Them: The problem is making good food choice. The drug helps with that.

You: The drug is a bandaid; just make good food choices.

Antidepressants are the best analogy here. If the core problem is in your brain (or brain-body integration), then, for now, exogenous compounds are the only way to address the core issue.

Re: What Ozempic does to the gut-brain axis

#489

Post by QuantumGood »

joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

The "here's where you're getting it wrong" discussions on glucagon‑like peptide‑1 receptor agonists are paralleling AI discussons. Interesting to watch these two domains of knowledge sparking (mis)framing arguments happening at roughly the same time.

Re: What Ozempic does to the gut-brain axis

#490

Post by giardini »

s1artibartfast wrote: post #445
faangguyindia wrote: post #324

Earlier quoted context omitted.

What do you eat in those 5000kcal calories? Genuinely curious.

as an aexample, I once ate a 5lb tritip over an afternoon, and that isnt counting breakfast or sides

Get checked for parasites, seriously! It will save you $$
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