Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#481

Post by theshackleford » Wed, Aug 06, 2025, 9:40 AM UTC

Spooky23 wrote: post #318

slavik81 wrote: post #288

Earlier quoted context omitted.

However, amphetamines such as Adderall were also sometimes prescribed for weight loss. I'm surprised it was done so rarely before Ozempic was a thing. They were quite effective.

Stimulants have well documented downsides. It’s one of the hard aspects for adults with adhd as you often need to taper as you develop heart issues.

This is not accurate outside of abusive dosages or those with pre-existing conditions and I know adult patients in their 70s and even 80s on stimulants.

Re: Ozempic shows anti-aging effects in trial

#482

Post by gtr » Wed, Aug 06, 2025, 9:42 AM UTC

rglover wrote: post #130

hinkley wrote: post #124

Earlier quoted context omitted.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

> That said, we are at a point where people are overweight enough that getting exercise has its own risks, and taking a medication that allows you to be more active is likely to cancel out some of those downsides. And yet we rarely ask or say "maybe I should just eat fewer calories?" Unless you have some other disorder that prevents normal bodily function, that does work (and would be viable I'd imagine for the major…

As someone who has been fat and not-fat throughout my life, I think literally everyone knows that it is simple to lose weight by eating fewer calories. That does not mean it is easy. If you are already fat, which can happen almost without you noticing by eating 200-300 calories too much a day over a year say, or as a result of some brain malfunction (both have happened to me), then eating the calorie deficit require to lose weight is mentally very hard to to.

As a thought experiment, imagine what you eat per day. Now halve it. Would you be having a good time?

Re: Ozempic shows anti-aging effects in trial

#483

Post by cyrillite » Wed, Aug 06, 2025, 9:45 AM UTC

throwup238 wrote: post #364

strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? There are several reasons: Chimps have a higher density of testosterone receptors with a higher sensitivity than humans. Compared to humans, they are essentially roided out all the time. Humans are also hairless endurance hunters so we naturally have much larger fat reserves (15-25% of…

Not to mention that we really are much more similar to chimps than they’re giving us credit for. If we ate a relatively low calorie, high protein diet, and maintained an active lifestyle, we’d all be pretty damn muscular and lean. Not roided out muscular, but far more so than I think the average person expects. Our body composition is significantly determined by relatively near-zero fitness demands in modern life and an overabundance of the wrong kinds of calories

Re: Ozempic shows anti-aging effects in trial

#484

Post by backscratches » Wed, Aug 06, 2025, 9:50 AM UTC

op00to wrote: post #204

throwawaylaptop wrote: post #193

Earlier quoted context omitted.

[flagged]

You’re a fool. “Pull out” does not protect against pregnancy or STDs. Pre-ejaculate can have viable sperm in it.

pre ejaculate contains zero sperm if you havent fully ejaculated previously. there is no mechanism for sperm to be released during preejaculation.

Re: Ozempic shows anti-aging effects in trial

#485

Post by minznerjosh » Wed, Aug 06, 2025, 9:53 AM UTC

throwawaylaptop wrote: post #142

radiofreeeuropa wrote: post #58

Earlier quoted context omitted.

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

I find it odd you included potatoes in the list of foods to give up. Boiled potatoes in particular rank at the very top of the satiety index[1], meaning they keep you full longer with less calories than other food (likely due to a combo of high water and fiber content.) I recently lost a modest 10 lbs and mashed potatoes (even with some added butter and milk) were a staple of my diet—keeping me from feeling hungry even at a calorie deficit.

[1] https://pubmed.ncbi.nlm.nih.gov/7498104/

Re: Ozempic shows anti-aging effects in trial

#486

Post by lazeythrowerb » Wed, Aug 06, 2025, 9:55 AM UTC

wraptile wrote: post #424

strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1 This strays too far into appeal to nature teritory. Evolution made us fit to reproduce not to age. As for "no free lunch" - we do have a lot of that in medicine historically speaking: iodine salt, clean water, vitamins (C, D), iron supplements, hormone theraphy, vaccines. The field of medicine is no stranger to free lunch.

Exactly! Further for evolution in the larger picture, it is actually necessary for living beings to die at some point, because of overpopulation. Survival instinct of the individual is only necessary to achieve enough reproduction. Death after reproduction age is necessary for evolution.

Re: Ozempic shows anti-aging effects in trial

#487

Post by sillyfluke » Wed, Aug 06, 2025, 9:56 AM UTC

Spooky23 wrote: post #315

DharmaPolice wrote: post #170

Earlier quoted context omitted.

Every person I know who tried to give up smoking has the same story - they were successful for a while and then they encountered some stressful moment (exam, work deadline, etc) and they fell off the wagon. One explanation could simply be that normally we have food stresses which manifests in general stress which we relieve via video games or whatever else. If these drugs turn down the volume of hunger then maybe thi…

I’ve taken a GLP for two years. It resets your dopamine reward system. It helped me lose 80 lbs and I’m running now. Zero craving for alcohol and sugar. But, my libido is like 3x lol. If some rando internet dude thinks I’m weak or stupid, fine with me. It’s a drug that has improved my life in ways that are difficult to describe.

>my libido is like 3x lol

Something that eliminates all your drives except your sex drive, a miracle drug surely.

Weird that this is not talked about more, but I don't see a lot of ads in general so maybe it is.

Re: Ozempic shows anti-aging effects in trial

#488

Post by sfn42 » Wed, Aug 06, 2025, 9:57 AM UTC

Aurornis wrote: post #220

cm2187 wrote: post #147

Earlier quoted context omitted.

and there are people who don't get fat no matter what they eat. Not sure what difference it makes to the millions of people I am refering to. Not even sure what is your point.

> and there are people who don't get fat no matter what they eat. This is a myth. When you actually track what these people eat, their daily caloric intake averages out to numbers you'd expect. At best, the difference between "fast metabolism" and "slow metabolism" people in studies comes out to a couple hundred calories per day. You may witness someone consume 2 pizzas and a soda in one sitting without getting fat,…

I feel like the word metabolism is often misunderstood. My metabolism is just the number of calories I need to maintain my weight. If I start being more active my metabolism increases, if I become less active it decreases.

So, metabolism is really just an expression of how active we are. Some athletes eat 5-10,000 calories a day just to maintain their weight. Hard working laborers also need a lot more calories than office workers.

Meanwhile, people blame their metabolism as if it's just a trait they can't control like their height. You absolutely can increase your metabolism, just move more. This is also likely a big reason why many people gain weight in adulthood - in school we have weekly gym classes and we spend lots of time running around ad playing with friends etc. Then we grow up and our activity level plummets, but we don't adjust our diet to accommodate our much lower metabolism.

Re: Ozempic shows anti-aging effects in trial

#489

Post by Nursie » Wed, Aug 06, 2025, 9:58 AM UTC

jxf wrote: post #455

strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1? We don't know. But one early signal is that you lose an atypical combination of muscle mass and not just fat, which is not a good evolutionary adaptation if you are an endurance hunter. https://healthcare.utah.edu/newsroom/news/2025/08/new-study-...

Muscle-mass loss is normal on any weight-losing diet, and the link says it is actually less than expected…

Re: Ozempic shows anti-aging effects in trial

#490

Post by gavinray » Wed, Aug 06, 2025, 9:59 AM UTC

toomuchtodo wrote: post #291

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

What's the difficulty level of obtaining Retatrutide through non traditional channels?

Quite easy, a single Google search

That will show you peptide sellers though with prices x10 higher than getting it directly from manufacturers in China