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What happened to the first cryogenically frozen humans?

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Re: What happened to the first cryogenically frozen humans?

#471
post #10

Years ago when I was in medical school, I concluded to improve quality of life, no matter how finite, is a better endeavour than to prolong it. There's something tremendously philosophically satisfying to recognizing that death is just the recycling of life so that new life can happen.

> death is just the recycling of life so that new life can happen.

This is Stockholm syndrome. We all die, so some of us choose to think it's a good thing. Death in general is needed for recycling, but not human death. Humans represent 0.00000001% (warning, made up number) of the available matter. We don't need to die for others to live.

Re: What happened to the first cryogenically frozen humans?

#473
post #432

Earlier quoted context omitted.

Uh? They already knew that which is why they tried to hide their tombs..

The builders of the pyramids tried to hide their tombs?

The pyramids were very early on in Egyptian history, they had a couple thousand years to refine the approach.

Re: What happened to the first cryogenically frozen humans?

#474

I wanted to know the state of Ted William's head, so I did a search. This is what I found: In "Frozen," Larry Johnson, a former executive at the Alcor Life Extension Foundation in Scottsdale, Ariz., writes that Williams' head was abused at the facility. Johnson claims a technician took baseball-like swings at Williams' frozen head with a monkey wrench. What?

I'll echo this with my own story.

Up in Nederland CO, there is the body of Bredo Morstoel. Most years the town holds the Frozen Dead Guy Days festival to celebrate his cryopreservation, complete with ice cream, coffin races, and frozen salmon tossing. Yes really.

I've been on the tour of his cryonics 'facility'. It is a Tuff Shed on the side of a mountain next to a chemical toilet and a home-made above ground nuclear bunker (with sliding glass doors). The Morstoel family was ... eccentric. During the 'champagne' tour, you are allowed to help restock Bredo Morstoel's tomb with dry ice and see his coffin. The coffin is in very rough shape and you can easily see his corpse.

He is very dead and is never coming back.

He looks just like Otzi the Ice Man. There is a lot of mildew in the corners of his styrofoam and plywood cryo-chamber-thing. He is not fully attached together anymore. His caretakers are, honestly, paranoid occult isolated libertarians.

Bredo Morstoel's dream isn't ever going to come true. He is dead and rotten now.

Re: What happened to the first cryogenically frozen humans?

#475
post #260

Earlier quoted context omitted.

> I'm absolutely shocked that more money and time is not spent researching how to cure death by aging. Faced with their own mortality, a bunch of aging billionaires and multimillionaires tend to pour money into longevity research. I'd be very upset if governments increased spending on fighting senescence today, instead of lower-hanging fruit .

When Elon was asked why longetivity research didn't pick his interest as worthy of an investment, he said: >It is important for us to die because most of the time people don't change their mind, they just die. If you live forever, we might become a very ossified society where new ideas cannot succeed.

I hope he changes his mind about Twitter soon

Re: What happened to the first cryogenically frozen humans?

#476
Isochoric supercooling looks much more promising. The body does not freeze solid. The temperature is lowered to below freezing, but all fluids remain fluids.

I'm not aware of experiments with animals, and obviously not humans. But here's an experiment with human cardiac tissue [1], which went quite well.

[1] https://www.nature.com/articles/s42003-021-02650-9

Re: What happened to the first cryogenically frozen humans?

#477

Never understood the quest for immortality. We are the children of our time. When our time passes, we will live as strangers in a strange land, drowning in the sea of nostalgia. Death will simply takes us back to where we came from before our birth. Don’t fear the reaper.

In case it's insightful, I've correspondingly never understood the common contentment with death. The world is an incredible place, and there's so much to experience and do. If I had the time there's hundreds of careers I could spend a lifetime in each trying to develop mastery. I think I could live a thousand lives with the people I care about and not be done. I've had to choose one life, and it's a nice one, but if…

> per-say

Quick note because you seem like the type of person who’d like to know, it’s “per se”: https://en.wiktionary.org/wiki/per_se

Re: What happened to the first cryogenically frozen humans?

#478

Earlier quoted context omitted.

> "Speak for yourself" Whom do you think I am speaking for? > " please don't confuse that for a good argument for the death of others with a different perspective. " "I want everything" is a youthful perspective that adults grow out of by gaining things and realising that drowning in endless things isn't happiness, it's a hoarding disorder. People with a PetaByte storage array of media aren't the happiest film watche…

> Whom do you think I am speaking for? I think you're speaking for "adults", given your next sentence. > "I want everything" is a youthful perspective that adults grow out of... Also: > > "I don't think longevity advocates generally want to prevent suicide or force people to live forever if they don't want to." > I suspect they are against suicide; why would someone who promotes longevity so much also be pro-dying-ea…

I have read Eliezer Yudkowsky's arguments in favour of longevity, and almost linked them myself. A few of them I can get behind - if there was no death, would we invent it? Probably not. But the cryonics ones I really can't agree with at all. Here in the UK we have a Conservative Prime Minister, a multi-millionaire who, together with his wife, is in the top 250 richest people in the country. And we have nurses, postal workers, transport workers, and more striking for more pay in the wake of the rising living costs, rising inflation, and energy price hikes (hikes which have lead to record profits for energy companies). The Prime Minister recently said that striking workers are "tired of being "foot soldiers" in the union's "class war"".

That's the kind of out of touch that E Yudkowsky's writing has, from his position of employing someone to sit next to him to remind him he's supposed to be writing Harry Potter fan fiction instead of procrastinating. Quite possibly I would agree more if I was a genius academic able to write about anything that interested me for a living and had an audience hanging on my every blog post. Here for example[1] is a LessWrong post from Gwern which I resonate more with. Quotes: "Next to life itself, freedom is the most precious value; and most people’s lives are functionally devoid of it. Many cryonicists fail to see this, because they are self employed, are in jobs that offer them compensating satisfaction, or that they don’t perceive as “work”". and "Heaven isn’t waking up from cryopreservation and having to go into work two weeks later – FOREVER. That is the very definition of hell for most people."

And even then it doesn't capture several things about cryonics arguments which bother me; the fiddling of the finances with insurance. Sure it may cost more than a normal person earns in a lifetime to cryopreserve someone, but if we handwave it away with "insurance" then it will all be fine. Insurance companies are scummy, the academic calculations about risk/reward/probability never take that real world fact into account, "markets are great" they say while everyday people are swindled by marketeers day in, day out. Or the delight in drastic medical treatments where the results may look good on paper, but look at people's lived experience of medical procedure aftermaths, problems they are left with, and it looks uncomfortably different. e.g. [2], c.f. how many doctors would personally refuse the old age treatments their elderly patients+families ask for. And then wonder what the actual lived experience of the cryo-revived would be, separate from the paperwork which says 'revived successfully'.

And then how self-satisified the whole thing is, e.g. from the Gwern post: "many of the arguments that make cryonics credible, require a remarkable degree of both intelligence and scholarship. Inability to understand the enabling ideas and technologies usually means the inability to understand, let alone embrace, cryonics.". Now that alone wouldn't change how likely it is to work, but consider Eliezer Yudkowsky who values his own intelligence more than most things; he is overweight and under exercised[3]. Caloric restriction is the only proven way to extend life in any creatures, and it's much more likely that it is effective in humans than it is that you personally will be cryonically revived, but he doesn't do it. Why not? Exercise is about the only proven way to slow IQ decline with age, something you'd think he would value highly, and it appears he doesn't do that either. Why not?

Compare with Ray Kurzweil and his book "the Fantastic Voyage - live long enough to live forever"[4], he has been partnering with a doctor for decades studying body biochemistry and interventions to improve his health and increase his life expectancy - and doing them - incredibly fiddly diet and micronutrient tracking and regular medical interventions at the doctor's office, dozens of regular blood tests. Seen through the lens of this book what it takes to try and live longer, makes it a bit less attractive to bother, doesn't it? Ray Kurzweil's reason was to live long enough to see the singularity in about 2035 and become immortal and revive his father. EY argues much more strongly for live extension than Ray Kurzweil, but apparently takes far less interest in doing anything about it today. The pro-cryonics arguments are often about how clever the cryonics suporters are for seeing a loophole in the universe - and conveniently it's a loophole that only needs an online signup with a credit card, but if you look at their 'revealed preferences', they aren't convinced enough to act on things which are much more likely to work but involve effort, so maybe agreeing with cryonics isn't about how intelligent you are, it's about how tempted you are to an easy low-effort fix?

Compared to most creatures on Earth we already have longevity, btw. Imagine how much more you could master if you hadn't spent so long commuting, washing vegetables, making your bed, showering, gazing out the window, vacuuming dust-catcher carpets, polishing silverware ... if you surgically removed all your life, how much more life you could cram in. Oh you don't want to give up eating delicious calories for decades for the hope of a few more years at the end? Funny, me either. You don't want to spend hours exercising for the hope of a few more IQ points near the end? Weird, I don't either. You don't want to wash your vegetables in acid and drink only filtered water and spend hours a week analysing your blood test results making microadjustments to your dozens of regular nutritional supplements using the latest medical study results for guidance?[5] Hah, guess what, me either.

[1] https://www.lesswrong.com/posts/mkrvsNi8cYGSjGqkh/on-the-unp...

[2] https://collateral-damage.net/ read the Preview of Chapter One. The developing full story used to be there as blog posts before it was turned into a book, you might find them on https://web.archive.org/web/20081215144025/http://adventures...

[3] https://live.staticflickr.com/6035/6262275090_186d29a15c_b.j... (belly)

[4] http://www.fantastic-voyage.net/ and https://www.goodreads.com/book/show/83538.Fantastic_Voyage

[5] Ray Kurzweil on supplements: "For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin." - now that's longevity in practise, who's still interested? Who even bothered to read this, let alone do it?

Re: What happened to the first cryogenically frozen humans?

#479

As someone that has frozen cells down many times successfully, I don’t think this will ever work for bodies. If you could save your DNA and a few cells and be cloned at a later date is that good enough for you? No memories but the same code. Is that still “you”? It’s like being an identical twin of yourself.

Can you imagine any experiment that will adjust your belief? Show you that there is a chance it might work for bodies?

Yes, any experiment that freezes down something large and multicellular like an organ and thaws it and it works.

The reason freezing cells works is that they have no large 3d structure and the surface area to volume works with the slow freeze down process (1 deg. C per min.) and rapid thawing (as fast as possible) necessary for them to survive.

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