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Ask HN: What startup/technology is on your 'to watch' list?

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Re: Ask HN: What startup/technology is on your 'to watch' list?

#471
post #19

Web Assembly It's interesting in a bunch of ways, and I think it might end up having a wider impact than anyone has really realized yet. It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies, and so on. It looks like it's going to enable a wider variety of languages on the web…

I don't like to see wasm replacing native for stuff like development tooling, and desktop apps. JITs may approach native performance in theory - but the battery consumption and memory consumption are not very good. ("Better than JS" is a low bar). As hardware becomes stronger, I would like to do more with it, and when it comes to portable devices, I want more battery life. Nothing justifies compiling same code again…

> I don't like to see wasm replacing native for stuff like development tooling, and desktop apps.

Wasm is like the JVM or CLR in that regard. It's not the future - it's the past.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#472
post #152
post #113

Oxford nanopore sequencing. If a few problems can be figured out (mainly around machine learning and protein design), then it will beat every other biological detection, diagnosis, and sequencing method by a massive amount (no 10x, but more like 100x-1000x) It's hard to explain how big nanopore sequencing is if a few (hard) kinks can be figured out. Basically, it has the potential to completely democratize DNA sequen…

Best part is the Oxford devices are _actually affordable_. Illumina has had such a stranglehold on the market - devices start at around 35k and go up into “this is a house now” territory. Meanwhile the Flongle [0] is $99 and the main Oxford device can be had for $1k. [0] https://store.nanoporetech.com/us/flowcells/flongle-flow-cel...

Depends what you mean by affordable - low barrier to entry, yes. But bases / $ is still orders of magnitude below where needed to displace Illumina for sequencing of large genomes (eg: human).

Re: Ask HN: What startup/technology is on your 'to watch' list?

#473
post #95

Self-driving cars. Now that the hype is over and the fake-it-til-you-make-it crowd has tanked, there's progress. Slowly, the LIDARs get cheaper, the radars get more resolution, and the software improves. UE5's rendering approach. They finally figured out how to use the GPU to do level of detail. Games can now climb out of the Uncanny Valley. The Playstation 5. 8 CPUs at 3.2GHz each, 24GB of RAM, 14 teraflops of GPU,…

> The Playstation 5. 8 CPUs at 3.2GHz each, 24GB of RAM, 14 teraflops of GPU, and a big solid state disk. That's a lot of compute engine for $400. Somebody will probably make supercomputers out of rooms full of those.

That seems like a straight waste of time for lightly customised hardware you'll be able to get off the shelf. And unless they've changed since, the specs you quote don't match the official reveal of 16GB and 10 teraflop. Not to mention the price hasn't been announced, the $400 pricepoint is a complete guess (and pretty weird given the XbX is guessed for 50% more… for a very similar machine).

Re: Ask HN: What startup/technology is on your 'to watch' list?

#474
post #469
post #382

Earlier quoted context omitted.

> Self-driving cars. Now that the hype is over and the fake-it-til-you-make-it crowd has tanked, there's progress. Slowly, the LIDARs get cheaper, the radars get more resolution, and the software improves. Still don't see fully (fully automated) self driving cars happening any time soon: 1) Heavy steel boxes running at high speed in built up areas will be the very last thing that we trust to robots. There are so many…

Of course the owner is to blame.

Counterpoint: In a fully-autonomous situation, of course the AI is to blame.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#475

1. https://www.starlink.com/ Finally, truly global and low latency satellite internet. 2. Generative models for video games - https://aidungeon.io/ is barely scratching the surface. Story, art, animation, music, gameplay, it will all be generated by models in the future. 3. New direct drive robotics actuators such as https://www.google.com/search?q=peano-hasel+actuators I think actuators are holding robotics back mor…

Jai? Jonathan Blow’s new programming language might be an option for you. https://inductive.no/jai/

Jai doesn't do very much in terms of memory safety, Zig [1] might be a better alternative + it actually exists.

1 - https://github.com/ziglang/zig

Re: Ask HN: What startup/technology is on your 'to watch' list?

#477
post #369

Earlier quoted context omitted.

Things like "It is the programmer's responsibility to ensure that std::string_view does not outlive the pointed-to character array." "string_view" is a borrow of a slice of a string. Since C++ doesn't have a borrow checker, it's possible to have a dangling string_view if the string_view outlives the underlying string. This is a memory safety error. Rust has educated people to recognize this situation. Now it's standa…

But surely it's a step towards more safety. Compare to passing char * around or ref/ptr to string. Sure C++ doesnt have a borrow checker but these types encourage the idea of "reifying" lack of ownership rather than keeping it ad hoc

You don't infer potential ownership from a C++ ref. Likewise for char* strings unless it is to interface with a C api, in which case you will keep it anyway.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#478
post #99

Optogenetics [0]. Light changes electrical behavior in cells. AKA, point laser, neurons fire, I know kung-fu Memristors [1] Rebuilding the entire computer from EE basics. New 'color' added to EE spectrum, now computers process huge datasets on a watch battery CRISPR-CaS9 [2] Tricks bacteria used to keeps viruses out are pretty slick. Crtl-C, Ctrl-V for gene editing. $100B technology, easily. Strangely (encouragingly?…

CRISPR-CaS9 seems to be pretty much "done" already. It's already used by many labs and high-profile projects, has transformed upcoming gene therapy pipelines and the main problems are being ironed out. I don't think that there is any doubt anymore that CRISPR is a big milestone in biotech.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#479
post #77

Earlier quoted context omitted.

Very similiar to https://www.datomic.com/

Materialize is based on differential dataflow, that is based on timelly dataflow. The abstraction works like magic: distributed computation, ordering, consistency, storage, recalculation, invalidations... All those hard to since problems are handled naturally by the computing paradigm. Maybe the product is similar, but not the principles behind

Principles only matter to hackers, but the end result for end users is identical.

It’s just very unfortunate that materialize has a much much bigger marketing team than the datomic people.

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