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Ask HN: What startup/technology is on your 'to watch' list?

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Re: Ask HN: What startup/technology is on your 'to watch' list?

#151
post #62

Earlier quoted context omitted.

Cautionary tale: we’ve been here before with JVM CPUs like Jazelle. They didn’t take over the world.

Even closer to home. Palm, RIM, Microsoft, Apple and Google have all said at one point that web apps were the answer for mobile apps....

I mean, modern Google was half-built on the back of the Gmail web app...

Re: Ask HN: What startup/technology is on your 'to watch' list?

#152
post #113

Oxford nanopore sequencing. If a few problems can be figured out (mainly around machine learning and protein design), then it will beat every other biological detection, diagnosis, and sequencing method by a massive amount (no 10x, but more like 100x-1000x) It's hard to explain how big nanopore sequencing is if a few (hard) kinks can be figured out. Basically, it has the potential to completely democratize DNA sequen…

Best part is the Oxford devices are _actually affordable_. Illumina has had such a stranglehold on the market - devices start at around 35k and go up into “this is a house now” territory. Meanwhile the Flongle [0] is $99 and the main Oxford device can be had for $1k.

[0] https://store.nanoporetech.com/us/flowcells/flongle-flow-cel...

Re: Ask HN: What startup/technology is on your 'to watch' list?

#153
post #71

Rust lang - Memory safety through zero cost abstraction as a way to eliminate a large class of errors in systems languages is interesting. Especially if it allows more people to write systems programs. WASM - Mostly as a compile target for Rust, but I think this changes the way software might be deployed. No longer as a website, but as a binary distributed across CDNs. ZK-SNARKS - Zero knowledge proofs are still nasc…

btw since two weeks ago the official Oculus Quest store is not sold out anymore (although it might be sold out again, haven't checked since it got back in store)

Re: Ask HN: What startup/technology is on your 'to watch' list?

#154
The general trend toward returning computing to the edge, which is just starting and has been accelerated due to COVID forcing BeyondCorp type practices on us.

Cognitive radio, ultra wide spread spectrum, and other radio tech that promises great range and license free or minimal licensing operation due to lack of interference with other stuff.

Rust is the first serious C/C++ replacement contender IMHO.

RISC-V and other commodity open source silicon.

Cheaper faster ASIC production making custom silicon with 100X+ performance gains feasible for more problems.

Zero knowledge proofs, homomorphic crypto, etc.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#157
post #77

Materialize https://materialize.io/ Incremental update/materialization of database views with joins and aggregates is super interesting. It enables listening to data changes, not just on a row level, but on a view level. It's an approach that may completely solve the problem of cache invalidation of relational data. Imagine a memcache server, except it now also guaranties consistency. In addition, being able to liste…

Very similiar to https://www.datomic.com/

Materialize is based on differential dataflow, that is based on timelly dataflow. The abstraction works like magic: distributed computation, ordering, consistency, storage, recalculation, invalidations... All those hard to since problems are handled naturally by the computing paradigm. Maybe the product is similar, but not the principles behind

Re: Ask HN: What startup/technology is on your 'to watch' list?

#158
post #19

Web Assembly It's interesting in a bunch of ways, and I think it might end up having a wider impact than anyone has really realized yet. It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies, and so on. It looks like it's going to enable a wider variety of languages on the web…

I want to believe... I always thought WebAssembly had a lot of potential, however, in practice it doesn't seem to have turned out that way. I remember the first Unity demos appearing on these orange pages at least 4 or 5 years ago, and promptly blowing me away. But, after an eternity in JavaScript years, I still dont know what the killer app is, technically or business wise. (Side note - I encourage people to prove m…

> I'd love to see examples of what WebAssembly makes possible that wouldn't exist without it.

I've been playing with WebAssembly lately and the moment where it clicked for me how powerful it was was building an in-browser crossword filler (https://crossword.paulbutler.org/). I didn't write a JS version for comparison, but a lot of the speed I got out of it was from doing zero memory allocation during the backtracking process. No matter how good JS optimization gets, that sort of control is out of the question.

I also think being able to target the browser from something other than JS is a big win. 4-5 years is a long time for JS, but not a long time for language tooling; I feel like we're just getting started here.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#159
post #31

zksnarks https://blog.ethereum.org/2016/12/05/zksnarks-in-a-nutshell/ Essentially let’s you verify computation is accurate without doing the computation yourself, and even treating the computation as a black box so you don’t know what is computed. Many applications in privacy, but also for outsourced computation.

One important weakness of zkSnarks is that it requires a trusted setup, for example [1]. A new alternative is called zk-STARK [2], which doesn't require the trusted setup, and is post-quantum secure. However, it significantly increases the size of the proof (around ~50KB). In general, hash-based post-quantum algorithms require bigger size and it would be interesting to watch the progress made in this regard.

[1]https://filecoin.io/blog/participate-in-our-trusted-setup-ce...

[2] https://eprint.iacr.org/2018/046.pdf

Re: Ask HN: What startup/technology is on your 'to watch' list?

#160

Materialize https://materialize.io/ Incremental update/materialization of database views with joins and aggregates is super interesting. It enables listening to data changes, not just on a row level, but on a view level. It's an approach that may completely solve the problem of cache invalidation of relational data. Imagine a memcache server, except it now also guaranties consistency. In addition, being able to liste…

+1, very excited about this. They're marketing it in the OLAP space right now, but at some point I'd like to try integrating it with a web framework I've been working on.[1][2] It'd be a more powerful version of firebase's real-time queries. Firebase's queries don't let you do joins; you basically can just filter over a single table at a time. So you have to listen to multiple queries and then join the results by han…

Thanks for the vote of confidence! One thing: We're not marketing it in the OLAP space. Our existing users very much are building new applications.

Initially we went for the metaphor of "what if you could keep complex SQL queries (e.g. 6-way joins and complex aggregations, the kinds of queries that today are essentially impossible outside a data warehouse) incrementally updated in your application within milliseconds? What would you build?

We're moving away from that metaphor because it seems it's more confusing than helpfuL. Tips always appreciated!

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