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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#421

Post by ehnto »

ifwinterco wrote: post #395
torginus wrote: post #335

Earlier quoted context omitted.

Yeah this is pretty much a nothingburger. I guess being fat causes biological damage similar to aging, and losing weight (which Ozempic helps with) reverses the process.

Yeah, it looks like it's basically just saying: 1) Being fat is really bad for you 2) Moderate calorie restriction may have some health benefits Both of which we already knew, the second one being a bit more controversial but a hypothesis that has been around for decades

I think it's controversial mostly because it is mixed in with morality, self-image, personal freedom etc.

I think everyone has the right to be fat, if they have chosen to prioritise other aspects of life, but I think people should be informed and consider the "being fat can be healthy" movement to be quite disingenuous. Do what you want, but be realistic about it, and tricking people into ignoring the negative effects is not fair to them either.

Re: Ozempic shows anti-aging effects in trial

#422

Post by RataNova »

pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group

Re: Ozempic shows anti-aging effects in trial

#423

Post by RataNova »

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

The gray market stuff makes me nervous

Re: Ozempic shows anti-aging effects in trial

#424

Post by wraptile »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1

This strays too far into appeal to nature teritory. Evolution made us fit to reproduce not to age.

As for "no free lunch" - we do have a lot of that in medicine historically speaking: iodine salt, clean water, vitamins (C, D), iron supplements, hormone theraphy, vaccines. The field of medicine is no stranger to free lunch.

Re: Ozempic shows anti-aging effects in trial

#425

Post by zosima »

aianus wrote: post #334
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

Is there a drug I can take to gain weight?

You have so much choice:

For the pure fat experience I suggest corticosteroids, lithium or a random antipsychotic. Insulin is also very useful here, but a tad dangerous.

If it has to be muscle mass, then anabolic steroids of course are preferable. But beta adrenergic agonists like clenbuterol also seem to have some effect.

And there are many more.

Re: Ozempic shows anti-aging effects in trial

#426

Post by johncolanduoni »

throwup238 wrote: post #383
johncolanduoni wrote: post #347

Earlier quoted context omitted.

How many times has a drug had negative effects that only showed up after 10-20 years? Out of all the drugs that have been widely prescribed in, say, the last 100 years? And it’s not even actually a new drug class - Liraglutide was approved in 2010! Should we wait until the clinical trial participants all die of old age until we put a drug on the market?

It took us 10-20 years to find out about tardive dyskinesia due to antipsychotic medications and the long term dependency and withdrawal effects of benzodiazepines. Two entire classes of drugs that are now in common use, so it’s not unheard of. I’m not saying we should take Ozempic off the market but don’t be fooled into thinking that we’re immune to unintended consequences just because we did a few studies (almost a…

At no point did I say we were immune to unintended consequences. Just that demanding every drug be used for 30+ years before you’ll touch it is not actually making an analysis of the tradeoffs involved.

Also, the drug classes you listed are not great examples. Benzodiazepines don’t fit what we’re talking about at all: it’s common to develop tolerance and get serious withdrawal symptoms from a few months of heavy use. You definitely don’t need to take them for 10-20 years (or even the 8 years since Ozempic was approved) to notice the serious side effects. If Ozempic killed you if you quit it cold turkey, we would already know. Psychiatrists were not unaware of what happened when you took too much Valium back in the 60s when it was first introduced. It’s just that they (and society in general) had an attitude toward risks that is totally alien to modern sensibilities (and to be clear, I think it was bad).

First-generation antipsychotic’s incidence of TD was strongly correlated with dose, which was strongly correlated with having schizophrenia and other mental illnesses involving psychosis specifically (as opposed to other indications like bipolar without psychotic features or major depression). Getting TD later in life but being able to live outside of an asylum (they were still around when first-generation antipsychotics were commonly prescribed) is probably a tradeoff many of these people would have taken, even if they knew about it.

Re: Ozempic shows anti-aging effects in trial

#427

Post by b800h »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

The other side of this is related to morals. People learned self-discipline by having to moderate their diet. Replacing that challenge with an injection is another example of a world in which people are not challenged to grow as people, but merely go out and buy something to make themselves feel or look better.

Re: Ozempic shows anti-aging effects in trial

#428

Post by freehorse »

mbac32768 wrote: post #306
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

This concept would be hard to grasp for me if I did not know personally a person facing such issue. I don't think most people can understand that "just eat more" does not work in such cases, because most people can eat just fine even if not really hungry.

Re: Ozempic shows anti-aging effects in trial

#430

Post by conradfr »

Der_Einzige wrote: post #249
brcmthrowaway wrote: post #242

Earlier quoted context omitted.

How does one get Ozempic without being overweight?

There’s armies of grey market don’t ask don’t tell e doctors who will give it to you with no request for evidence of being overweight. Thank god for poor regulation. Unironically thank god and may this situation continue.

So the South Park special was kind of based on reality?
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