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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#421

Post by StefanBatory »

mlsu wrote: post #381
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…

I was obese myself, and I have different thoughts on that.

For me, it was purely an issue of personal falling and willpower issue. I was obese because of a diet I was indulging in; full of unhealthy things and snacks.

It was due to nobody else but myself.

Re: How long til we're all on Ozempic?

#422

Post by aezart »

ActorNightly wrote: post #401
paulmist wrote: post #249

Earlier quoted context omitted.

What is a realistic path to this? Being from Europe I visited US last year and was horrified at the quality of your food. You see a lot of documentaries/youtube videos/etc... discussing the problem, but how do you even go about this?

The first thing that would help is actually having a realistic discourse about food, and not the idiotic - "You shouldn't be eating processed food, its not good for you". Like most of the food that we eat is not really that bad. Its not optimal for sure, especially for sedentary lifestyles, but a lot of the health problems are not directly tied into the actual food, rather the over-consumption of it, and passing down…

> (for example, children of obese people are more likely to be obese)

I would assume that this is related to gut biome and not genetic makeup.

Re: How long til we're all on Ozempic?

#423

Post by itronitron »

robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

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Re: How long til we're all on Ozempic?

#424

Post by listenallyall »

mlyle wrote: post #330
llamaimperative wrote: post #256

Earlier quoted context omitted.

GP isn't talking about self-control, they're talking about the fact we've created a system that requires obscene amounts of self-control if you wish to maintain physical health. People in the 50s weren't slimmer because they had ironclad determination to stay such.

> People in the 50s weren't slimmer because they had ironclad determination to stay such. No. They lived in an overall healthier environment. But they were also subject to much greater social pressure to stay slim and could endure fairly intense social judgment and stigmatization for weights that we consider normal (particularly women).

"Overall healthier environment". Meaning, food was relatively scarce. No Starbucks, Dunkin Donuts, convenience store on every corner. Coca-cola was not available in 2-liter bottles or in 24 packs of cans. No Costco-sized mutlipacks of anything.

In the 1950s, malnutrition was a serious issue that many people in poor areas died from. When was the last time someone died because they didn't have access to food? Obviously, the other side of that coin is that food being so plentiful, people eat much, much more than ever before.

Re: How long til we're all on Ozempic?

#425

Post by throwaway019254 »

dfxm12 wrote: post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

To paraphrase: Instead of relying on medication that helps with issues caused by our society, let's completely change the society so it's no longer the issue?

That's very idealistic, in my opinion.

Re: How long til we're all on Ozempic?

#426

Post by skeeter2020 »

squidlogic wrote: post #337
llamaimperative wrote: post #256

Earlier quoted context omitted.

GP isn't talking about self-control, they're talking about the fact we've created a system that requires obscene amounts of self-control if you wish to maintain physical health. People in the 50s weren't slimmer because they had ironclad determination to stay such.

In my experience fitness is less about self control or will power and more about creating routines that lead to fitness. For example, I have a routine of going to a group fitness class at my gym in the morning. I don't need to summon willpower, I just have a morning routine that involves doing x thing at y time. No thought required. Given the abundance of options for fitness classes and meal plan services, you really…

Routines help because they reduce the impact and uniqueness of the good behaviour. Another approach is to do things that have high positive pay-off but include health benefits you wouldn't target but get "for free". Example: I ride my bike to work because it's awesome, faster and makes me feel superior. That I get exercise and help out the earth is a side effect; I'd probably still ride my bike if it was unhealthy and produced more CO2

Re: How long til we're all on Ozempic?

#427

Post by vessenes »

rafaelmn wrote: post #400
dyauspitr wrote: post #376

Earlier quoted context omitted.

Sounds like a miracle drug that helps with all afflictions that come with our modern life/sedentary living.

I'd say it's the opposite - if you don't exercise you end up skinny fat which is metabolically unhealthy as well. It helps with super accessible dopamine hits I guess - which is awesome - but need to combine it with exercise for maximum benefit. I wouldn't be surprised if they come up with a drug for that that's more sideffect free than testosterone/ derivatives. Lean and ripped cocktail

This is true, but I'd qualify it. I'm MUCH more active than when I started, just naturally, and my heart health / true age stats (for what they're worth) are twenty years lower than when I started. I lost a lot of muscle, but as a percentage, my body fat is nearly half what it was when I started. 10/10 would do again.

Recomping is a huge struggle, you just can't eat enough to add muscle bulk. Cycling on and off is tough because if you don't taper off it, your body is like "thanks for ending that long term caloric deficit, have you heard of cake?". So you definitely need to approach the muscle mass question seriously, but in no world was I healthier back when I had an extra 10 to 20lbs of muscle, and the rest in fat.

Re: How long til we're all on Ozempic?

#428

Post by rory »

cubefox wrote: post #110
apsec112 wrote: post #8

This compares Ozempic with past drugs, but sales of past drugs are almost always limited by demand. I'm not sure there's much to learn here for a drug that is limited by supply. Also, this part is silly: "The announced investments across both companies total $32 billion. GLP-1s were 71% of Novo’s revenue in 2023, 16% of Lilly’s in 2023, and 26% of Lilly’s in 2024Q1. If these sales are proportional to the manufacturin…

And apparently the pure manufacturing cost for Ozempic is relatively low: > the active drug in Ozempic can be produced for about 29 cents for a month’s supply, or 7.2 cents for a typical weekly dose, the research found. It’s not cheap to make — semaglutide costs over $70,000 per kilogram. But only a tiny quantity of the drug is used in each weekly dose. > https://fortune.com/europe/2024/03/28/ozempic-maker-novo-nor..…

By chance I just talked to someone with deeper knowledge on this and they said the current constraint is actually ramping up supply of the delivery mechanism, not the drug.

I have zero expertise on this, but would be curious if anyone knows what's special about Ozempic delivery that can't be served by a commodity syringe.

Re: How long til we're all on Ozempic?

#429

Post by apwell23 »

robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

Have you noticed any effect on gastric emptying. As someone with 'tummy issues' ( ibs/gerd ect) i am apprehensive of messing with my digestive systems.

Re: How long til we're all on Ozempic?

#430

Post by apwell23 »

itronitron wrote: post #423
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

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They don't need marketing team writing posts on HN. The drug sells itself and even shortages all over the world.
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