Earlier quoted context omitted.
That is also the symptoms of the ordinary flu which is the more likely candidate.
Lassa fever also occurs often in Nigeria
What's the relationship between Lassa fever and covid-19 ?
A (possible) solution to Covid-19
421–430 of 585 posts
Re: A (possible) solution to Covid-19
#422Earlier quoted context omitted.
ADE is more a problem for the vaccine approaches. It is one reason we may never have a vaccine for this disease. Hard to rule out worst case scenarios, we just have to work with what we have and make hard choices.
>ADE is more a problem for the vaccine approaches. It is one reason we may never have a vaccine for this disease. This is at least partly why there are no SARS/MERS vaccines. There's a paper I'll try to dig up where 4-8 (can't remember) modified vaccine candidates were tested in multiple animal species, and in each case except one, immunity was conferred but exposure to the virus lead to a dangerous autoimmune respon…
My understanding is that we had SARS vaccine candidates ready for human testing, but funding died off once SARS disappeared.
Re: A (possible) solution to Covid-19
#423Earlier quoted context omitted.
This was the UK government's plan until they realised just how many people would die as a result.
Thats false. The UK's plan was to not quarantine ANYone. The young are basically immune to this. I'm saying quarantine the vulnerable populations and let the healthy populations out.
Just before I get into discussing this idea, I'm curious how sure you are about it. The way you describe it it's pretty much a simple solution that just needs implementing.
How do you know exactly what the outcome would be?
Re: A (possible) solution to Covid-19
#424Earlier quoted context omitted.
You’re ignoring the fact that this virus Is an order of magnitude more lethal than the flu, and I would guess that most individuals in poorer countries skip the vaccine altogether.
It has only been proven lethal for very old and people with chronic illnesses. Those people should stay at home and practice distancing.
Are you just igoring news that fly in the face of what you're stating here? Have you looked at the current state of NYC?
Re: A (possible) solution to Covid-19
#425Earlier quoted context omitted.
> And then it turns out similar to "Ethics" Perhaps, but that's Star Trek. It wasn't always obvious how the episode would end. > Pretty wild to count Enterprise as "real Trek", but not Discovery. Why? TNG, DS9, VOY and ENT, together with movies from TMP to NEM, form a certain coherent whole - both artistically, with themes, styles, pacing, and story-wise with a shared universe. Both Discovery and Picard, as well as J…
I mean, yes, Berman/Braga era Trek has a fairly consistent style both visually and thematically because that's how they wanted it, but to privilege that style as "real" (or "proper", as you have it) requires considerable justification as yet not provided. Even from that era, First Contact not only used a largely horror/action-movie style then unprecedented in Trek, but went far out of its way to cast doubt on the Fed…
> but to privilege that style as "real" (or "proper", as you have it) requires considerable justification as yet not provided
It's arguably the largest consistent body of work in the entire Star Trek franchise, the one that was the peak of its popularity, the one that fleshed out the universe and is most recognizable. Also somewhat unique compared to other science fiction, which I can't say about post-ENT installations.
> Was First Contact therefore less "real"?
Nah, I consider it real because - besides mostly staying thematically and stylistically consistent - in terms of storyline, it critiqued the "ethically more evolved" humanity; it shown shades of gray of an otherwise mostly white object, instead of making it black with occasional lighter tones, like post-ENT installments do. It's the same defense I'd give DS9. It's still the same utopian world, the same beacon of hope - just not a perfect utopia.
(Also: throughout TNG/DS9 and the movies, the Federation did feel like an actual character in the movies. ENT was leading up to it, and it portrayed humanity growing up towards the TNG-era utopia. This aspect seems completely missing from Discovery/Picard; both the Federation and Starfleet seem to exist there just to have a flag and an icon to slap on things.)
Unlike JJ movies, I'm not considering DIS and Picard as completely bad. I've noticed and appreciated the point about Picard brought up in his eponymous series, as much as I appreciated the concerns of Klingons in DIS - their point about Federation being a cultural threat to them would fit perfectly fit TNG-era Trek, and add further depth to their race. And I tried to be fair to both DIS and Picard, to watch them without biasing myself against them - but they really don't fit the whole in my eyes. They stand out as something totally different in almost every way.
> But the Trek fandom has ever qualified their shows as especially worthy not for the quality of their visuals, but for that of their ideas. From that perspective, a lot of TNG, and of its era more generally, struggles today.
I've been rewatching TNG (and DS9) quite recently, and the way I feel, it's the concerns that aged, not the ideas. I.e. TNG (and DS9) cover themes that were the concern of society of the 80s and 90s, which seem less relevant today, but I don't feel like the way of thinking of the characters has aged badly.
Re: A (possible) solution to Covid-19
#426Earlier quoted context omitted.
Why did they choose indiegogo over traditional medical research funding?
Good question. I am even surprised why not Kickstarter - it's more suitable for the larger goals.
Flexible funding allows one to keep the proceeds even if the goal is not met in the allotted time. Kickstarter offers only an all-or-nothing payout for projects (unless something changed the last time I checked).
Re: A (possible) solution to Covid-19
#427In one of the article comments there is an interesting suggestion on reviving the research on DRACO[1]: > In cell culture, DRACO was reported to have broad-spectrum efficacy against many infectious viruses, including dengue flavivirus, Amapari, and Tacaribe arenavirus, Guama bunyavirus, H1N1 influenza, and rhinovirus, and was additionally found effective against influenza in vivo in weanling mice. It was reported to…
Why did they choose indiegogo over traditional medical research funding?
The source that wikipedia cites says the following:
"However, research on DRACOs has entered the well-known “Valley of Death” in which a lack of funding prevents DRACOs, and many other promising new drugs, from being developed and advancing toward human medical trials. To progress DRACOs research it needs to be demonstrated against clinically relevant viruses (i.e; HSV). To that end an IndieGoGo campaign (http://igg.me/at/EndTheVirus) was started on October 13, 2015."
They don't seem to elaborate on what the hell they mean by the valley of death.
Re: A (possible) solution to Covid-19
#428Earlier quoted context omitted.
This is an attenuated live vaccine, though. So the risks are similar or worse than just doing a real, engineered vaccine. If it's mere paperwork, we can solve that with a regular vaccine just as fast. And the regular vaccine would be more likely to be safe, even at an early stage. (Note: I'm a rando, not a medical or biological professional.)
if bureacracy held up the spread of a live coronavirus, we wouldn't be in this mess
The proposal is to intentionally apply a live virus to people, so absolutely there are bureaucratic barriers to this (and for good reason). There is no a priori reason why this should have less red tape than a dead virus.
If we're just going to ignore any regulations and bureaucracy for a live virus (like this proposes), we can do the same for a dead virus.
Re: A (possible) solution to Covid-19
#429Could we already start with this? There are almost no deaths in young people, so how about we send the youth to a Corona Summer Camp for a week or 3? https://www.worldometers.info/coronavirus/coronavirus-age-se...
How much % of young people end up in ICUs or hospital ? The numbers are always elusive about that.
According to CDC :
Age group (yrs) 0–19 (123 cases) Hospitalization 1.6–2.5 ICU admission 0 Case-fatality 0
Re: A (possible) solution to Covid-19
#430I totally missed it from the article but how is he going to tell the deadly strain from the less deadly one? I mean I understand how they can tell the difference between the two strains. But how to tell that some particular strain is less deadly? To the best of my understanding the only way to get there is to sequence the virus from statistically significant number (~10^5 ??) of carriers including the significant pro…
Not to mention relying on each person's account of the severity of the symptoms, and coding that into a dataset that corresponds to the sequencing results. You need a LOT of asymptomatic people with the strain in order to draw any strong conclusions.
The upside is, you may draw other very interesting conclusions while collecting data for this mission, and be able to "pivot" if you will.