I remember reading this published insight[1] from Marissa Mayer a few months ago: Burnout is caused by resentment Which sounded amazing, until this guy who dated a neuroscientist commented[2]: No. Burnout is caused when you repeatedly make large amounts of sacrifice and or effort into high-risk problems that fail. It's the result of a negative prediction error in the nucleus accumbens. You effectively condition your…
>>The best way to prevent burnout is to follow up a serious failure with doing small things that you know are going to work. If you are making large amounts of sacrifice towards high risk problems and failing. You are likely doing something wrong and merely backing them up with 'small wins' is not going to help and shouldn't help. The best thing in that case is to really burnout and quit, to do things that are better…
Startups are a perfect example of this. We see serial entrepreneurs fail spectacularly (see Color), we read about entrepreneurs who kill themselves after a string of failures, and we read all of the time about the new guys and girls who tried their hardest yet never managed to take off. People like to write about "why my startup failed", but they are hurting a lot more than they let on.
Entrepreneurs shouldn't be risk adverse. If you want risk adverse, go work at Google. At the same time, we should understand what it means to live in high risk mode, and learn to recognize warning signs (depression, burn out, loneliness, etc.) in ourselves and others so that a high risk lifestyle can be manageable and even healthy.