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MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

sciencedaily.com

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Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#41

Post by throwforfeds »

lelanthran wrote: post #19
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

> The "surprising way" is by using a derivate of LSD. What's the difference between a derivate and a derivative? (I'm not being facetious, I'd really rather like to know)

They can control the supply and make more money off of it. And you can pay lobbiests to make sure the original LSD stays illegal.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#42

Post by rdtsc »

> It's usually treated with medications like Zoloft and Paxil that boost and stabilize the neurotransmitter serotonin, leading to reduced anxiety and enhanced emotional well-being

How do figure the boost and stabilize part for a patient? Do they take samples of neurotransmitters in the spinal fluid before and after and looking for neurotransmitter concentrations?

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#43

Post by throwforfeds »

goodmythical wrote: post #32
jijijijij wrote: post #16

Earlier quoted context omitted.

Calling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.

Call me a luddite, but I'd personally honestly preferring knowing my chemist so that I can be relatively certain there's no 2-ci or whatever bs the kids are cutting with or straight up substituting these days. My understanding is that, today in the US (and other markets so far as I know), it is far easier to know a pharmacist than a genuine LSD chemist, though I am several years out of that particular market. Would b…

While I agree that I'd love to have a guarantee on purity, the way to do that is just to make LSD legal, rather than have some private equity backed pharma company tie up the supply. LSD should be a case like insulin or the polio vaccine, as it offers an immense amount of potential for the planet.

Sure, if they want to make money by offering retreats in clinical settings for people too afraid to spend an afternoon with a loved one on 100ug of LSD, by all means. But jumping through hoops to lock up the supply of a truly revolutionary molecule that could improve the lives of millions just feels bad to me.

Edit: Also, no one is putting 2c-i on a tab of LSD. The doses are way different (~100ug vs 15mg) and chemists that make LSD tend to be pretty sold on it's potential to help humanity and try to keep the supply as pure as possible.

You may be thinking of "tusi" or pink cocaine, which is a drug mixture that tends to have ketamine and mdma mixed, and often has had fentanyl creep into the supply. Someone just decided to name it similar to Shulgin's 2C class of drugs for some reason, which is annoying and dangerous.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#44

Post by daft_pink »

titzer wrote: post #35
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

Why can't they just put it in the title of the article instead of classic clickbait tactics? Ugh.

I agree. I have anxiety sometimes, but I’m not about to start taking LSD. I’m not going to risk a permanent psychological crisis to reduce my anxiety. It’s not really a cure if it has a even a small percentage chance of causing something much worse.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#45

Post by gavmor »

jml7c5 wrote: post #23
kykat wrote: post #5

It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.

HN has some peculiar medical fixations. It comes in waves. For a while there were a lot of submissions about intermittent fasting. 15 years ago people were excited about polyphasic sleep. 10 years ago it was all about modafinil. Enthusiasm about ketamine for depression was big, but it seems to have finally fizzled out.

Wonder what the approach would be to empirically determine these waves.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#46

Post by jijijijij »

goodmythical wrote: post #32
jijijijij wrote: post #16

Earlier quoted context omitted.

Calling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.

Call me a luddite, but I'd personally honestly preferring knowing my chemist so that I can be relatively certain there's no 2-ci or whatever bs the kids are cutting with or straight up substituting these days. My understanding is that, today in the US (and other markets so far as I know), it is far easier to know a pharmacist than a genuine LSD chemist, though I am several years out of that particular market. Would b…

Yeah, of course that's all legit concerns and demands. However, I dislike the notion this "dangerous street drug" was graciously made to somethings "useful" and safe by the pharma industry. It's the same its always been. Especially around the time of its prohibition.

I am calling out a pattern. It's a bit similar to pharma going into the jungle, taking some natural compound (possibly known to an indigenous tribe), modifying the chemistry just enough to patent it and call it a miracle. The dealer gets life in prison, the Sackler family literally killed thousands, but merely had to pay a fine and do some rebranding.

If LSD wasn't arbitrarily outlawed, your concerns wouldn't exist. ID and purity considerations are purely consequences of being made illegal. It was always synthesized by highly educated and responsible chemists, because the chemistry demands it. It was never an honest public health concern, it's not addictive, practically lacking any toxicity.

MDMA also got this treatment. Immersion with the collectivist teachings of Christ was decided a sinful desire, but now treating the PR problem of broken cogs in the war machine may be ruled acceptable in the eyes of God.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#47

Post by Ylpertnodi »

thin_carapace wrote: post #17
analog8374 wrote: post #3

"Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Here's Tom with the weather." -Bill Hicks

today an evolved monkey realized that the evolution of intelligence via genetic algorithms doesnt line up that well with the scientific trajectory of existence since the big bang , he then realized that his perception of existence would be exactly equivalent to that of a brain in a jar , his final realization was that all realizations are epheremal regardless as to how convincing or conclusive they may seem

I can trip to that.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#48

Post by tmaly »

titzer wrote: post #35
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

Why can't they just put it in the title of the article instead of classic clickbait tactics? Ugh.

There will always be a need to drive more clicks and more comments.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#49

Post by danaris »

gausswho wrote: post #38
IAmBroom wrote: post #31

Earlier quoted context omitted.

Near as I can tell, they are essentially synonyms, but in practice "derivate" is "a product obtained chemically from a raw material", while "derivative" tends to be used in the mathematical or financial senses.

Kinda like orient and orientate. Maybe there's a word for this class of variations. Or variants?

Or variates?

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#50

Post by adammarples »

tim-projects wrote: post #21

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.

The control is where you have the medical staff around but not the drug. I believe placebo control groups are pretty common.
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