Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

sciencedaily.com

Post reply on HN
Print view View original

31–40 of 108 posts

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#31

Post by IAmBroom »

lelanthran wrote: post #19
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

> The "surprising way" is by using a derivate of LSD. What's the difference between a derivate and a derivative? (I'm not being facetious, I'd really rather like to know)

Near as I can tell, they are essentially synonyms, but in practice "derivate" is "a product obtained chemically from a raw material", while "derivative" tends to be used in the mathematical or financial senses.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#32

Post by goodmythical »

jijijijij wrote: post #16
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

Calling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.

Call me a luddite, but I'd personally honestly preferring knowing my chemist so that I can be relatively certain there's no 2-ci or whatever bs the kids are cutting with or straight up substituting these days.

My understanding is that, today in the US (and other markets so far as I know), it is far easier to know a pharmacist than a genuine LSD chemist, though I am several years out of that particular market.

Would be nice to know there's been a resurgence of access to ergot via improvement in Claviceps growth or some nifty novel synthesis we didn't have a few years ago.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#33

Post by IAmBroom »

tim-projects wrote: post #21

I'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.

You are fabricating a lot of details about the study to come to that conclusion.

If only there were experts on the ground, designing the experiment, who could plan to avoid such interfering variables.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#34

Post by catigula »

These psychedelic treatments always have substantial limitations, and this is no different;

1. Low volume cohort i.e. 40 participants per dose group

2. Industry sponsored study i.e. MindMed.

3. Think about it; how do you blind psychedelics? It's pretty obvious you're on one when you take it.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#35

Post by titzer »

Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

Why can't they just put it in the title of the article instead of classic clickbait tactics? Ugh.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#36

Post by IAmBroom »

kykat wrote: post #5

It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.

"Drugs" can cure polio and dysentary; alleviate headaches and menstrual cramps; lower blood pressure; and regulate brain biochemistry in ways that make dysfunctional people able to function again. And sometimes they enable happy feelings.

Yes, drugs are amazing.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#37

Post by tokai »

lelanthran wrote: post #19
Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

> The "surprising way" is by using a derivate of LSD. What's the difference between a derivate and a derivative? (I'm not being facetious, I'd really rather like to know)

MM120 is just a patented LSD. So its just a brandname LSD.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#38

Post by gausswho »

IAmBroom wrote: post #31
lelanthran wrote: post #19

Earlier quoted context omitted.

> The "surprising way" is by using a derivate of LSD. What's the difference between a derivate and a derivative? (I'm not being facetious, I'd really rather like to know)

Near as I can tell, they are essentially synonyms, but in practice "derivate" is "a product obtained chemically from a raw material", while "derivative" tends to be used in the mathematical or financial senses.

Kinda like orient and orientate.

Maybe there's a word for this class of variations. Or variants?

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#39

Post by aswegs8 »

OutOfHere wrote: post #13

Of course they want to repackage a cheaply synthesized substance at 100-1000x the costs even though the original likely works just as well. That's pharma for you.

It's just the tartrate salt of LSD. It isn't even a derivative of it. Does not have any other effects pharmacologically.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#40

Post by aswegs8 »

Rygian wrote: post #4

The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."

It is no derivate. It's just the tartrate salt of LSD. There is no pharmacological difference. It's like saying I got this new Magnesium Tartrate which is now different to the Magnesium Oxide / Citrate / Glycinate / whatever you are taking. It might affect stability or absorption rate or similar, but Tartrate itself doesn't have an effect.
Post reply on HN