Live data from Hacker News

Weight loss jabs: What happens when you stop taking them

bbc.com

41–50 of 125 posts

Re: Weight loss jabs: What happens when you stop taking them

#41
post #19

Being overweight is a chronic disease. Just like alcoholism, or any kind of other addictions. I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop. I have th…

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

> It feels like gaining weight is incredibly easy and losing it is incredibly hard

I feel like there is more to it.

Obviously, I sympathize with you, and I noticed that when I switch from a bulking cycle to a cutting cycle, it is a bit difficult to adjust for the first couple of weeks as well.

But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed. And when I don’t work out aggresively and don’t keep track of my cycle, it feels just natural for me to default to eating way less, as opposed to the other way around.

To be clear, this isn’t meant to be a dig at your take. All I mean is that, I feel like the whole issue is a bit more complex.

Re: Weight loss jabs: What happens when you stop taking them

#42
post #24
post #19

Earlier quoted context omitted.

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

> the problem is not that fat people are so unbelievably stupid that they didn't know this I don't suggest this applies to you, but even a small amount of searching around and reading stuff on the web will reveal a substantial subgroup of outright thermodynamics deniers.

Can you provide an example of someone who outright denies thermodynamics?

I’m familiar with people who believe that there are details of how a body metabolizes fuel , expends energy, and generally operates that escape analysis focused on fuel volume and physical activity. I am familiar with people who characterize this as denial of the laws of thermodynamics, but I am not familiar with anyone who seems to believe that there are situations in which the laws of thermodynamics are outright suspended.

Re: Weight loss jabs: What happens when you stop taking them

#43
post #19

Being overweight is a chronic disease. Just like alcoholism, or any kind of other addictions. I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop. I have th…

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

There's a lot of very visible and conscious messaging about losing weight.

There's an equal and opposite level of messaging to keep eating, which is less conscious and runs under the radar.

Snacks are literally designed to be addictive. TV ads start from birth. Most restaurants have huge portion sizes. "Family" and "Festival" events assume overeating is expected. Junk food is cheap and quality food is expensive. Overeating is framed as being "naughty" but also indulgent and nurturing.

All of this is a huge social problem that's not acknowledged at all.

It's very, very hard to Just Eat Less when there's a constant barrage of messaging encouraging you to do the opposite, and you're not even aware of it.

The contradictory messaging is actually a classic crazy-making psychological double bind. So of course it's very difficult to make a dent in this, and even harder to permanently change habits so all the contradictions no longer influence you.

Re: Weight loss jabs: What happens when you stop taking them

#44
post #24
post #19

Earlier quoted context omitted.

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

> the problem is not that fat people are so unbelievably stupid that they didn't know this I don't suggest this applies to you, but even a small amount of searching around and reading stuff on the web will reveal a substantial subgroup of outright thermodynamics deniers.

> outright thermodynamics deniers

I've heard people say this before, but when reading those arguments it mostly turns out to be people who think there's something more complicated going on with digestion, excretion, or metabolism such that eaten calories are more efficiently used for some, and burned off or passed through without full processing to some degree for people who self-reportedly "can't gain weight".

Re: Weight loss jabs: What happens when you stop taking them

#45
post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that. It’s not like others like myself, currently on a cut cycle, don’t experience hunger. The idea that we are just “lucky” ignores all the willpower and discipline we fight through to do it ourselves. I’ve eaten about 800 calories today and it is 4pm. Just finished 90 minutes on the indoor bike. My stomach feels h…

How can you say that with any certainty, though? How do you know that hunger hits you in the exact same way it does another person? That overcoming it requires the exact same amount of willpower in all people?

Re: Weight loss jabs: What happens when you stop taking them

#46

Earlier quoted context omitted.

I don’t think that’s a fair assessment. I’m all for life-long drugs that help with weight loss, I don’t view it as a moral failing. That said, it is easy to see why so many people are concerned about these drugs: people taking them can look terrible (“ozempic face”). Gaunt, sick, hollowed out, look at people like Sharon Osbourne, that’s the public face of these drugs. And so when people are committing to life-long us…

"Ozempic face" is actually just "unhealthy rapid weight loss face". Ozempic makes it easier to starve yourself, but that isn't how it's supposed to be used.

It’s also accelerated muscle loss, even heart tissue. I‘m not saying it’s not worth it, but this should be kept on the radar for sure.

Re: Weight loss jabs: What happens when you stop taking them

#47
post #19

Earlier quoted context omitted.

It's frustrating. "Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us. My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the…

There's a lot of very visible and conscious messaging about losing weight. There's an equal and opposite level of messaging to keep eating, which is less conscious and runs under the radar. Snacks are literally designed to be addictive. TV ads start from birth. Most restaurants have huge portion sizes. "Family" and "Festival" events assume overeating is expected. Junk food is cheap and quality food is expensive. Over…

Most restaurants have huge portion sizes.

ppl keep blaming this, but this is contradicted by shrinkflation, yet people still are getting fatter than ever. There is nothing to stop someone from buying more food to offset smaller portions.

Re: Weight loss jabs: What happens when you stop taking them

#48

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0] The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consu…

> Revita basically re-surfaces the duodenum. Does this reduce mucous production going forward? Otherwise, it seems like it would be a temporary effect.

My impression (and I'm not a scientist) is that the mucosal overgrowth comes from eating an obesogenic diet. (Some combination of too much sugar / salt / wrong types of fat?)

If you get the procedure and don't go back to an obesogenic diet, then it should be permanent.

Re: Weight loss jabs: What happens when you stop taking them

#49

Earlier quoted context omitted.

I don’t think that’s a fair assessment. I’m all for life-long drugs that help with weight loss, I don’t view it as a moral failing. That said, it is easy to see why so many people are concerned about these drugs: people taking them can look terrible (“ozempic face”). Gaunt, sick, hollowed out, look at people like Sharon Osbourne, that’s the public face of these drugs. And so when people are committing to life-long us…

"Ozempic face" is actually just "unhealthy rapid weight loss face". Ozempic makes it easier to starve yourself, but that isn't how it's supposed to be used.

Taking Ozempic also drops a lot of muscular mass and that ozempic face look totally makes sense.

There's no free lunch or wonder drug. While it's effective at weight loss it has a lot of unwanted side effects. And when stopping the drug the weight gain comes back so not sure if it's worth it.

Re: Weight loss jabs: What happens when you stop taking them

#50
If you’re substantially overweight, you have to wonder if the long term side effects of GLP-1 are better than being obese

That said, its a little disheartening to see people who are 10-15kg overweight also resort to these drugs - this kind of excess weight can be fought with simply diet and exercise

Post reply on HN