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From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

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Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#41

Post by renewiltord »

neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

It's just that when something is widespread enough you can actually study other effects it has. Sort of like how psilocybin and weed had all these other effects but we couldn't study them till they got a little less criminalized. All sorts of shit does stuff, but we grandfathered in substances and froze everything for a while. Then COVID came along and a bunch of people started doing telemedicine and before you know it compounding pharmacies were handing out GLP-1RAs as a substitute for the phentermine they were passing out. Not scheduled, absolutely effective, great stuff.

Then with all that use in the wild you could rock and roll. Only problem is that off-label use like me with my retatrutide makes some population studies less effective than before.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#43

Post by arjie »

jodje wrote: post #36

how is 26 people statistically relevant??

Well, that depends on the effect size etc. right? There's a chocolate bar in front of you and your two buddies. You split it in thirds. As soon as one of your buddies eats his, he drops dead. Your other buddy says "Sample size of 1. Psh. Billions have eaten chocolate.". He eats his. Drops dead. The sample size is now 2. You eat yours or not?

If the answer is yes, well all right.

If the answer is no, weaken the effects until you see what crosses the threshold of "should we study this more?".

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#44

Post by [deleted] »

neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

[deleted]

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#45

Post by basisword »

tracker1 wrote: post #28
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

All I know is I had some miserable side effects that started after a couple years that just progressively got worse while on them... when I found out it was the Trulicity/Ozempic I stopped, and the effects coming off were nearly as miserable... took almost a year to recover coming off and still dealing with the fallout.

Curious how you tied the side effects to GLP-1 when they didn't appear for a year and took so long to go away after stopping? Is it possible it was unrelated?

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#46

Post by barrenko »

testing22321 wrote: post #40
johnfn wrote: post #33

Earlier quoted context omitted.

One reported benefit from Ozempic is that it improves self control. For instance, there are some studies that show it's easier to stop smoking on Ozempic[1]. I can't think of any way that would be modulated just by being less overweight. [1]: https://www.goodrx.com/classes/glp-1-agonists/semaglutide-fo...

Once you have proven to yourself you can eat less and lose weight, you believe you can do the same with other things like smoking. Makes sense

That's not how it works.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#47

Post by barrenko »

borski wrote: post #16
llm_nerd wrote: post #9

Earlier quoted context omitted.

GLP-1 is a naturally occurring hormone regulating blood sugar, satiety, and gastric emptying. Some people simply don't have enough naturally (which can be a result of diet composition and lifestyle -- there are diet and behaviour modifications to increase your natural production) and artificial supplementation is beneficial. The overwhelming benefits from GLP-1 are courtesy of weight loss and better blood sugar contr…

This is absolutely correct. I couldn’t have said it better myself. (Except I’ll note that’s true for more than one hormone, as tirzepatide is both a GLP1 and GIP agonist, and I believe retatrutide is also Glucagon?)

"Incretins" is the keyword here.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#48

Post by sheepdog »

aksss wrote: post #30
asafira wrote: post #25

Earlier quoted context omitted.

There is large-enough consensus on this drug for its main use cases (treating diabetes and obesity), but more importantly for this conversation: it's actually quite common for drugs to get new indications after their initial one --- at which point, there might be a new, broader consensus on what the drug is good for. Clinical trials are designed to treat a very specific subclass of individuals; pharmaceutical compani…

[flagged]

I didn't get any LLM vibes from the comment at all. I'd heard of "off label use" and other incidental use-cases. So the comment makes a lot of sense...

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#49

Post by borski »

barrenko wrote: post #47
borski wrote: post #16

Earlier quoted context omitted.

This is absolutely correct. I couldn’t have said it better myself. (Except I’ll note that’s true for more than one hormone, as tirzepatide is both a GLP1 and GIP agonist, and I believe retatrutide is also Glucagon?)

"Incretins" is the keyword here.

Indeed! Thank you!
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