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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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41–50 of 217 posts

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#41
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

So, literally "no pain, no gain" ?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#42
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose.

Roughly:

- Paracetamol overdose can cause severe liver damage and may be fatal.

- Ibuprofen in high doses can lead to kidney injury and stomach bleeding.

- Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidosis.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#43
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

Just NSAID’s - they’re anti-inflammatory and muscle synthesis happens in response to inflammation.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#44
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

Anti-inflammatories - not all painkillers.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#45

[flagged]

Not denying that acetaminophen/paracetamol has a horrible therapeutic index, but there are reasons why it is still so widely used. Despite potential hepatoxicity, it is considered the safest pain relief drug (this emerging research notwithstanding)

Ibuprofen is not better in every way. For instance ibuprofen, as well as other NSAIDs, is much less gentle on gastrointestinal tract and puts much more strain on kidneys.

Some people (e.g. with inflammatory bowel diseases or renal diseases) do not tolerate NSAIDs well, which is why acetaminophen is on the same step of analgesic ladder - it is still considered better in some cases. Both are also used complementary to each other in pediatrics.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#46
post #12
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

The vaccine-autism smoking gun that Andrew Wakefield and RFK Jr. heroically tried to find has, so far, failed to turn up. But there was a study recently that showed that autism is correlated with the mother taking acetaminophen during pregnancy.

Or maybe it's genetic. Or whatever. Cite yer sources matey, or it be all hot sargassum.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#47
post #38

Earlier quoted context omitted.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

Same goes for icebaths, they reduce inflammation, which is the whole point of working out.

Does the opposite hold true as well? If I taunt a wasp nest after hitting the gym will I discover the fast route to mad gains?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#48
post #47
post #38

Earlier quoted context omitted.

Same goes for icebaths, they reduce inflammation, which is the whole point of working out.

Does the opposite hold true as well? If I taunt a wasp nest after hitting the gym will I discover the fast route to mad gains?

You'll certainly get swole.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#49
post #12
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

The vaccine-autism smoking gun that Andrew Wakefield and RFK Jr. heroically tried to find has, so far, failed to turn up. But there was a study recently that showed that autism is correlated with the mother taking acetaminophen during pregnancy.

The general advice is to not take any medication during pregnancy without a physician’s advice. This includes all over the counter medicines.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#50
post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

NSAIDs reduce inflammation. Since inflammation is part of healing, they can slow recovery, but they’re useful when inflammation itself is a problem.
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