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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#41

Post by metalman »

V__ wrote: post #9

Any study which uses epigenetic clocks can be discarded. There is to my knowledge no test which produces reliably measurements which don't have big error bars. The only conclusion this study can really make is: Ozempic changes the 'thing' which the epigenetic clock test also measured.

it does seem that there is no reliable connection with "epigenetic clocks" where people are shown to be dying at the same bio age, regardless of calender age......all of the mortality estimating calculations rely on many "factors", so the "ozempic" effects will be just part of a puzzle, where I will bet anything that attitude, demenour, , basic personal conduct will weigh in as the hinge pins that everything else pivots around..........stress, and how that is delt with, and anyone who thinks that one compound is going to reset the whole clock on a complex organism is kidding themselves, which if done right, works ;) so....it's all for the good

Re: Ozempic shows anti-aging effects in trial

#42

Post by readthenotes1 »

Someone1234 wrote: post #39
thurn wrote: post #34

Are we close to having generic semaglutides e.g. available in India? Or locked into high prices for the foreseeable future?

Generic Semaglutide is already produced on a massive scale throughout the world. However, it is unlawful to import and sell and will remain so until 2032 in the USA. In other markets, where it is under patent, it is significantly cheaper than the $500/month or more in the US currently. For example in the UK it is roughly $150/month USD privately (i.e. not through the NHS). In China it will be out of patent within two…

Iirc, that pricing will change in the US as Trump will require that the price of drugs to Medicaid patients must match or be less than that of any other developed nation.

Since about 1/4 of the people in the US are on medicaid, close to 90 million, that means the drug manufacturers will probably raise the price for everyone else in the US because they got to get their profits somehow...

https://www.whitehouse.gov/fact-sheets/2025/07/fact-sheet-pr...

Re: Ozempic shows anti-aging effects in trial

#43

Post by neves »

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news.

My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU.

The long-term systemic effects of these drugs are still largely unknown.

Re: Ozempic shows anti-aging effects in trial

#45

Post by stronglikedan »

noah_buddy wrote: post #20
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat.

As an American with a sister with thyroid issues, I can say that is absolutely not true for the majority of Americans. People are mostly sympathetic to those who are not obvious slobs.

Re: Ozempic shows anti-aging effects in trial

#47

Post by jorts »

neves wrote: post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

Haven’t these types of drugs been in use for ~15 years?

Re: Ozempic shows anti-aging effects in trial

#48

Post by stronglikedan »

jbentley1 wrote: post #16
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.

I'd wager that you can only call an engineer talented if they know enough to hate AI coding.

Re: Ozempic shows anti-aging effects in trial

#49

Post by jsbg »

neves wrote: post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

> The long-term systemic effects of these drugs are still largely unknown.

The long term effects of obesity are very well known though and unlikely to be better than any still unknown negative effect semaglutide might have.

Re: Ozempic shows anti-aging effects in trial

#50

Post by radiofreeeuropa »

Someone1234 wrote: post #39
thurn wrote: post #34

Are we close to having generic semaglutides e.g. available in India? Or locked into high prices for the foreseeable future?

Generic Semaglutide is already produced on a massive scale throughout the world. However, it is unlawful to import and sell and will remain so until 2032 in the USA. In other markets, where it is under patent, it is significantly cheaper than the $500/month or more in the US currently. For example in the UK it is roughly $150/month USD privately (i.e. not through the NHS). In China it will be out of patent within two…

There's a whole little online subculture of people in the US importing the precursors and making it themselves at home for dirt-cheap.

I gather it's extremely easy and basically fool-proof, as far as producing the desired drug and not producing some other, undesired drug. Much easier than, say, home-brewing beer. The risk is all in contamination, which presents a vector for infection.

[EDIT] I don't mean to downplay the risks or suggest people go do this, only to highlight that there's enough demand for this that we're well into "life, uh, finds a way" territory, and also just how lucky (assuming these hold up as no-brainers to take for a large proportion of the population) we are that these things are so incredibly cheap and simple to make, if you take the patents out of the picture.

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