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High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

medicalxpress.com

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Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#41

Post by elric »

kpfleger wrote: post #36
nostrebored wrote: post #27

Earlier quoted context omitted.

Yes, 90% of the world’s population does not absorb dietary vitamin D well, which should make people skeptical of this result.

Nonesense. It's well established that dietary D3 (or D2, but D3 is better) clearly incleases 25(OH)D serum levels. It is that serum biomarker whose deficiency (levels below 20ng/ml or 30ng/ml) that has the largest association with higher risk of dozens of diseases as well as all-cause mortality. You can defend your phrasing by saying that "not well" just means one has to take a lot of it. Yes, there is a wide variety…

Is the blood level diagnostically significant with vit D? Or is this something like magnesium where serum levels can be normal while having a magnesium shortage? IIRC vit d is fat soluble, does the body store any excess quickly, or does it linger around?

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#42

Post by canucker2016 »

elric wrote: post #41
kpfleger wrote: post #36

Earlier quoted context omitted.

Nonesense. It's well established that dietary D3 (or D2, but D3 is better) clearly incleases 25(OH)D serum levels. It is that serum biomarker whose deficiency (levels below 20ng/ml or 30ng/ml) that has the largest association with higher risk of dozens of diseases as well as all-cause mortality. You can defend your phrasing by saying that "not well" just means one has to take a lot of it. Yes, there is a wide variety…

Is the blood level diagnostically significant with vit D? Or is this something like magnesium where serum levels can be normal while having a magnesium shortage? IIRC vit d is fat soluble, does the body store any excess quickly, or does it linger around?

Yes, from https://pmc.ncbi.nlm.nih.gov/articles/PMC5577589/

  The goal of this study was to investigate whether the relationship between body composition, serum 25-hydroxyvitamin D (25OHD), vitamin D in subcutaneous (SQ) and omental (OM) adipose, and total adipose stores of vitamin D differ among OB and C. ... In summary, although OB had significantly greater total vitamin D stores than C, the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the OM and SQ fat compartments was similar.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#43

Post by adamgordonbell »

justinko wrote: post #28
adamgordonbell wrote: post #6

I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…

Always take magnesium with vit D. Ask an LLM why.

I do take magnesium, but I could try to up it when I take D. Thanks

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#44

Post by adamgordonbell »

canucker2016 wrote: post #38
adamgordonbell wrote: post #13

Earlier quoted context omitted.

Yeah, experimentation makes sense. I've had it happen twice, with two different dosages. First time was at a higher dosage than 1000 and I think it happened sooner. I'm just calling it out here, because sometimes you get lucky and someone else had the same issue and has the answer and will resolve the mystery. I'm not saying Vit D is bad, I'm just curious if others have had difficulties with it. My doctors opinion on…

Never had/heard of your problem with Vitamin D. A web search brings up - https://www.reddit.com/r/Biohackers/comments/1ia6yyb/update_... tl;dr - some Vit D supplements are based on lanolin. if you're sensitive to it, you may switch to a supplement that doesn't use lanolin. also one response talks about taking a multi-Vitamin B supplement for anger issues with Vit.D

This is helpful. I will try this!

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#45

Post by trevorkoob »

adamgordonbell wrote: post #35
trevorkoob wrote: post #32

Earlier quoted context omitted.

Curious. Could you please share your physical activity level around the time of supplementation? One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massive doses of vitamin D. The result of the massive doses were that patience had less hip fractures, but more falls compared to the control. Now take this next part with a grain of sa…

I run 3-5 times a week but otherwise pretty sedentary.

Thank you for replying!

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#46

Post by trevorkoob »

elric wrote: post #40
trevorkoob wrote: post #19

Earlier quoted context omitted.

Did a masters on Vit D. Multiple overdoses of over 1 million IU have been recovered from without obvious long-term damage present in near term follow up. Out of vitamin D’s many potentially clinically positive effects some of the clearest and best evidence is for increased muscle strength. Personally I take between 5000-10000 IU D3 daily depending on exposure to sun intensity.

Care to share your thesis? Sounds interesting! What was your degreee in?

The hypothesis was: is it beneficial to supplement vitamin D to reach the maximum levels achieved through sun exposure year-round?

Conclusion: these types of studies did not exist at the time, but the risks of doing such studies would be minimal, and such studies would be able to test for the effects of higher dose supplementation that were lacking at the time. Potential benefits include increased muscular strength and bone strength.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#47

Post by OutOfHere »

Tade0 wrote: post #14
VladVladikoff wrote: post #4

I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be. I can’t find the article which caused me to originally start my 7500 IU regiment but there…

> I’ve personally been taking 7500 IU daily for many years now. And here I am debating whether increasing to 4000 was pushing my luck. I am also reporting less illnesses - or actually - no instances of being bedridden, which is an improvement over the previous flu seasons.

It depends on your sun exposure and kidney health. In the elderly with a compromised kidney, 4000 can push them over a sane limit. For most people though with minimal sun exposure, 4000-5000 is pretty good, and certainly will make them less sick. For optimal effect, stack with calcium and magnesium as citrate or better.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#48

Post by OutOfHere »

vitanxiety wrote: post #37
Sunspark wrote: post #29

Earlier quoted context omitted.

Out of curiosity, the various brands, were any of them in liquid form? The reason I ask is because it's possible to be intolerant or allergic to one of the filler ingredients in a tablet.

No, they weren't, and that's a good suggestion that I need to try.

Get a well-rated softgel form without iffy ingredients like caramel coloring.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#49

Post by OutOfHere »

GrantMoyer wrote: post #30

Too much Vitamin D can calcify your soft tissues, so be cateful following some of the reccomendations in these comments. https://en.wikipedia.org/wiki/Vitamin_D#Excess

Up to 5000 IU per day is unlikely to result in a concerningly high level of D3 or calcium in someone with minimal sun exposure. Also, caffeine drains nutrients like calcium away. Those with compromised kidneys will have to be more careful.

Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

#50

Post by audunw »

chasebank wrote: post #17

I remember reading about how the current recommended dose of Vitamin D was a statistical error in a study and has since been corrected to the tune of 10-11x higher. "The recommended daily intake of vitamin D has a long history, originally set at 400 IU/day in the early-to-mid 20th century, including the 1970s, primarily to prevent rickets in children and bone disease in adults. In 2010, the Institute of Medicine (IOM…

It should be said that there are experts that still argue strongly that we shouldn’t casually take large doses of Vitamin D. It’s not actually a vitamin. It’s a steroid hormone.

You can easily be misled about how much vitamin D you need because the skin makes a huge amount of it when exposed to sunlight.. but it does that as part of the process of protecting itself from sunlight, not because the body necessarily needs that much vitamin D.

Before you take large doses you should read and understand these articles.

https://www.devaboone.com/post/vitamin-d-part-1-back-to-basi...

https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st...

https://www.devaboone.com/post/vitamin-d-part-3-the-evidence

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