Significant breakthrough in search for Parkinson's biomarker

Post by techwiz137 » Mon, May 01, 2023, 11:38 AM UTC

EvanAnderson wrote: post #17

c3534l wrote: post #12

My grandmother had Parkinson's and it was awful. How long until I can go to the doctor, get some blood drawn, and see if I'll develop it one day?

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.

Post by defrost » Mon, May 01, 2023, 11:48 AM UTC

logicchains wrote: post #37

aintgonnatakeit wrote: post #34

The first study has 3 patients. The second study is a little better, but not by much. Both have the same first author. If this were legitimate, some academic medical center in the US would have picked it up. Parkinson’s is a huge target, and this kind of thing makes a career. This is likely on the same level as horse dewormer for COVID.

>This is likely on the same level as horse dewormer for COVID You mean something that's demonstrated to have a statistically significant protective effect in a majority of studies but was attacked mercilessly by the pharma industry and the media they fund because they can't profit from a generic drug like that? https://c19ivm.org/meta.html

Post by giantg2 » Mon, May 01, 2023, 11:54 AM UTC

_qua wrote: post #20

Mizza wrote: post #11

Earlier quoted context omitted.

The cynic in me assumes that it's because this is not a patentable drug. EDIT: MJF foundation is aware of it at least - https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... , but points out problems with the study. Further Googling quickly leads to the usual quackery about the magical properties of different supplements and vitamins. Hope this goes somewhere though.

No way. About five years ago there was a quack-y study about reducing death in sepsis which called for high-dose vitamin C, thiamine and steroids. None of these are patent protected. The first study purported to show a 100% reduction in mortality. There were many RCTs done after this which did not bear out the effect, and it has now essentially been proven to be ineffective. it is possible to fund studies without ind…

Post by giantg2 » Mon, May 01, 2023, 11:57 AM UTC

Mizza wrote: post #11

jtbayly wrote: post #10

Earlier quoted context omitted.

If this Was discovered 10 years ago, I’m assuming it must be fairly limited in helping, or the results haven’t lasted or something?

The cynic in me assumes that it's because this is not a patentable drug. EDIT: MJF foundation is aware of it at least - https://www.michaeljfox.org/news/thiamine-vitamin-b1-and-par... , but points out problems with the study. Further Googling quickly leads to the usual quackery about the magical properties of different supplements and vitamins. Hope this goes somewhere though.

Post by giantg2 » Mon, May 01, 2023, 12:01 PM UTC

EvanAnderson wrote: post #17

c3534l wrote: post #12

My grandmother had Parkinson's and it was awful. How long until I can go to the doctor, get some blood drawn, and see if I'll develop it one day?

What would you do if you found out you would? (I ask as someone whose great-grandfather, great-uncle, and grandfather all had Parkinson’s.) I’ve avoided any testing because, as far as I know, there’s nothing preventative to be done. I’d love to hear otherwise. I’ve broached the subject with my last two primary care physicians and both advised that there was no point in knowing.