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CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

mdpi.com

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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#41

Post by coldacid »

meowface wrote: post #29
blip54321 wrote: post #3

Earlier quoted context omitted.

It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.

When you say "the vaccine", do you mean the mRNA vaccines specifically, or all of the vaccines?

From reading the paper, it'd be all of the vaccines, or at least all that build on the spike protein as the target for our immune systems to focus on.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#42

Post by sethammons »

Commodore63 wrote: post #12
TravisDick wrote: post #2

I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?

The spike protein from the vaccine is injected into your muscle and does not circulate through your system.

How does that explain the cases of myocarditis?

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#43

Post by j16sdiz »

revolvingocelot wrote: post #21
TravisDick wrote: post #2

I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> I'll again point out that however the spike might fuck with B and T cells, the full-blown virus will surely do more.

Sure. And the full-blown virus trigger the same immune response and create the same spike protein..

BUT, this is all about risk management. If you live alone in somewhere very low infection rate and don't meet people, there is no point taking this risk.

If you need a vaccine, there are safer (but less effective) alternative vaccines.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#44

Post by LurkingPenguin »

hlieberman wrote: post #34

This is published by a predatory publisher ( https://en.wikipedia.org/wiki/MDPI#Controversial_articles ). According to homozygoat ( https://www.twitch.tv/homozygoat ), it doesn't use real virus (rather, it uses other cells transfected to express some covid proteins), and uses the wrong cell type for the conclusions they try to draw.

So we should ignore everything published by MDPI but take as gospel something stated by a PhD candidate in molecular biology who livestreams on Twitch under the name Homozygoat and has 329 followers there?

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#46

Post by coldacid »

resoluteteeth wrote: post #11
coldacid wrote: post #7

Earlier quoted context omitted.

[flagged]

The virus also produces the spike protein

And that made targeting the spike protein with the vaccines a good idea? No. The spike protein itself is the problem, regardless of its source. The vaccine designers picked a bad target.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#47

Post by revolvingocelot »

koolba wrote: post #38
revolvingocelot wrote: post #21

Earlier quoted context omitted.

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> Searching for a means by which the vaccine might meaningfully damage your adaptive immune system is ill-advised. Frankly, we've got terrifying amounts of information about the deleterious effects of catching and surviving serious COVID, and administration of a vaccine tends to uncontroversially downgrade the seriousness of the COVID infection that you will almost assuredly get eventually. Thus, even if the vaccine…

>Explicitly saying nobody should look into a potential negative side effect of vaccines because they might actually find something is down right scary.

You didn't read the article. Or what I wrote about it. The vaccine can't do any worse than the virus, and this study, that does look into a potential negative side effect, found that the virus does indeed do worse!

Scaremongering while putting words into someone else's mouth is why there is mistrust.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#48

Post by j16sdiz »

dvdhnt wrote: post #35
revolvingocelot wrote: post #21

Earlier quoted context omitted.

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> Thus, even if the vaccine harms you in some way, COVID itself will do worse. And that’s the TL;DR folks. Seriously, this distillation makes the choice very easy.

The choice ain't that simple... There are multiple vaccines.. They varies in effectiveness and safeness.

Depends on where you are, the risk of getting inflected varies too.

It is good to stay informed, not blindly take anything you can get.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#49

Post by nnx »

LurkingPenguin wrote: post #14

The key finding: > Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows…

Aren't inactivated virus vaccines (like Sinovac's) also expressing the full-length spike protein?

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#50

Post by coldacid »

steve_taylor wrote: post #16
coldacid wrote: post #7

Earlier quoted context omitted.

[flagged]

That doesn’t make sense.

How so? No matter how you get the spike proteins in you (virus, mRNA vaccine, or traditional vax using the spike protein as target) the preferential targeting of the virus for immune system cells, combined with the properties being exhibited by the spike protein, means that the immune system isn't able to properly develop the immunity you should be getting from infection or from vaccination.

If a different target from the virus was chosen, perhaps it'd be a different story, but going for the spike protein without having a fuller understanding of what it does in our cells has made the vaccines for SARS-CoV-2 questionable given the findings in this paper.

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