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A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

nytimes.com

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Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#41

Earlier quoted context omitted.

I treat my treatment resistant depression by inducing 101+ fever for half an hour each day. I started when I had to stop an allergy to the EMSAM patch. There are also medications that you might not have heard of. If you want, I can write more when I'm not on mobile.

I would like to know more.

I learnt about it from this interview of about depression inflammation research:

> Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona. Dr. Raison’s research focuses on inflammation.

https://www.youtube.com/watch?v=6DtJGJWjDys

While the protocol he is implementing (and most hyperthermia protocols I have seen) involve temperatures reaching 104-105 degrees, in the interview they discuss a possible connection to hot yoga and sauna use, which would not involve such high temperatures.

I would assume that it would easiest to try something like this at a sauna in a gym for a few week or so - all else you would need would be a thermometer. I picked up a bunch of IR lamps and a couple of space heaters, and set them up in a space just big enough to do push-ups in. The entire setup cost ~$200.

http://i.imgur.com/aM3BCbE.jpg

I have been getting my temperature to 100 degrees via the lights and the heaters, spending another ten minutes trying to increase it from there (it is usually close to 102 by the time I stop), then resting for another 20 minutes with the heaters and lights not quite as overbearingly close. I've also started incorporate pushups and planks and drink a quart of hot tea (watch out with this and the thermometer :) )

At first I thought it wasn't doing much for depression, but continued to use it due to dramatic and unexpected improvements in my other immune conditions. After skipping it a few times, it became very obvious what effect it was having on my mood, which noticeably and reliably lifts around 20 minutes or so of reaching 100 degrees.

Overall, it takes an hour a day. The process is tiring, and once your temperature starts getting above 100, you can't concentrate or do very much: even watching TV becomes a chore. And while it hasn't alleviated my depression, it's had enough of an effect that I'm no longer willing to go without it.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#42

Earlier quoted context omitted.

I treat my treatment resistant depression by inducing 101+ fever for half an hour each day. I started when I had to stop an allergy to the EMSAM patch. There are also medications that you might not have heard of. If you want, I can write more when I'm not on mobile.

What are these alternative meds?

I was thinking specifically of Pramiplexole.

Pramipexole in Treatment Resistant-Depression, Possible Role of Inflammatory Cytokines:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143506/ https://www.nature.com/articles/npp2016217.pdf?origin=ppub

Antidepressant-like effect of pramipexole in an inflammatory model of depression.

https://www.ncbi.nlm.nih.gov/pubmed/27825895

Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606303/

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#43

Earlier quoted context omitted.

Not for half an hour, unless you have someone patient with a kettle. I have seen one journal abstract where that that was used, but I don't know the details. There are better methods though, if you have the budget of a hospital or research center, such as IR lights filtered through water. There's also a article outlining various methods of inducing hyperthermia.

Well, perhaps not by itself . I used to take an ear thermometer in the tub with me, dunk my head, check temp in both ears to make sure I hit 102, then wrap up in bedding, fully covered, for 20 minutes or so. Edit in reply to your edit: Yes I also preheated water on the stove and had assistance from a family member, though technically no kettle was involved. There are no doubt better methods if you have scads of money…

I've spent ~$200 on this.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#44

Earlier quoted context omitted.

Well, perhaps not by itself . I used to take an ear thermometer in the tub with me, dunk my head, check temp in both ears to make sure I hit 102, then wrap up in bedding, fully covered, for 20 minutes or so. Edit in reply to your edit: Yes I also preheated water on the stove and had assistance from a family member, though technically no kettle was involved. There are no doubt better methods if you have scads of money…

I've spent ~$200 on this.

For some people, that would be a lot of money.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#45

Earlier quoted context omitted.

The parent did not dispute that diet can have a significant effect on health, including mental health, only the particular examples you mentioned. Lithium in particular is a well known case that's been researched and has plenty of supporting literature. I have not seen comparable studies supporting the use of rosemary or Vitamin C for the indications you mentioned and the latter in particular seems unlikely unless yo…

This is one of the links in my original comment: https://news.ycombinator.com/item?id=16140867 I've already stated that these decisions are based on research. I don't plan to try to "prove" anything here to people being dismissive of me rather than genuinely interested in what I know. I deal with far too much of that and it never, ever goes good places. The parent did not dispute that diet can have a significant effe…

> And I cannot comprehend how anyone who sees themselves as scientific can genuinely insist in earnest that the power of belief has more influence over my physical body than the power of food chemistry.

It would appear belief can have an extreme severe acute impact on our bodies. It follows then belief can also have chronic affects.

People can die simply because they've given up, life has beaten them and they feel defeat is inescapable, according to new research.

The study, by Dr. John Leach, a senior research fellow at the University of Portsmouth, is the first to describe the clinical markers for 'give-up-itis', a term used to describe what is known medically as psychogenic death.

https://m.medicalxpress.com/news/2018-09-people-die.html

HN discussion here https://news.ycombinator.com/item?id=18083509

It appears you didn’t comment on that one, so perhaps you missed it?

Also, it stands to reason the affect of foods, herbs, essential oils, what have you, on people probably follows a bell curve distribution and therefore there are likely to be extreme outliers. This may explain why some people experience significant clinical effects from, say, Rosemary and Sage, while others not.

This brings me to something I like to highlight: the difference between public health policy and individualised medicine. It might not be sound public health policy to put essential oils in the water, although I’m not aware of any rigorous studies, but may be sound advice for a component of individualised wholistic care.

Disclosure: I’ve dabbled in nutritional and herbal medicine, with four years of formal study and the resultant certifications, here in Australia. For what it’s worth.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#46

I've long suspected that my depression & OCD were caused by some immune response. It all started very suddenly when I had a very bad illness. Unfortunately I have yet to find a doctor that believes me and is willing to do anything other than giving me the standard medications.

If you haven’t tried the Wim Hof method, please give it a go. It might not work for you as well as it has for others, but it won’t cost you anything to try it.

To heal depression or OCD or both?

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#47

Earlier quoted context omitted.

This is one of the links in my original comment: https://news.ycombinator.com/item?id=16140867 I've already stated that these decisions are based on research. I don't plan to try to "prove" anything here to people being dismissive of me rather than genuinely interested in what I know. I deal with far too much of that and it never, ever goes good places. The parent did not dispute that diet can have a significant effe…

> And I cannot comprehend how anyone who sees themselves as scientific can genuinely insist in earnest that the power of belief has more influence over my physical body than the power of food chemistry. It would appear belief can have an extreme severe acute impact on our bodies. It follows then belief can also have chronic affects. People can die simply because they've given up, life has beaten them and they feel de…

Thank you. It's a reasonable comment. Unfortunately, in the context of multiple people being incredibly dismissive, it somewhat comes across as just another dismissal, though I sincerely believe you don't mean it that way.

For context, my official diagnosis is atypical cystic fibrosis. I was diagnosed a bit over 17 years ago. I had been bedridden for several months and had a hole in my left lung.

Classical CF accounts for about 1/3 of all adult lung transplants and 1/2 of all pediatric lung transplants in the US. It has a very low life expectancy and you typically take about $100k worth of drugs annually to manage it with no hope of actually getting well.

So I have a lot of baggage from internet strangers insisting that the hole in my lung closing and my ability to get off multiple prescription drugs etc is obviously due to placebo effect and couldn't possibly be due to extensive dietary and lifestyle changes, nor could I possibly actually know a fucking thing of any value at all, what with being a woman and former homemaker.

I'm leaving this discussion now. Nothing personal against you. I'm just fed up with people attacking my personal anecdotes in a way that doesn't automatically get done to other people who say "I have X diagnosis and I do Y thing for it." Other people can talk about their health and how they manage it without everyone piling on to inform them they are a nutcase who imagined the entire thing.

Other points I make are consistently ignored in order to focus on what I said about my firsthand experience and tell me that I don't know what I experienced. Some internet stranger has more expertise in my life than I have.

Ugh.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#48

Earlier quoted context omitted.

> And I cannot comprehend how anyone who sees themselves as scientific can genuinely insist in earnest that the power of belief has more influence over my physical body than the power of food chemistry. It would appear belief can have an extreme severe acute impact on our bodies. It follows then belief can also have chronic affects. People can die simply because they've given up, life has beaten them and they feel de…

Thank you. It's a reasonable comment. Unfortunately, in the context of multiple people being incredibly dismissive, it somewhat comes across as just another dismissal, though I sincerely believe you don't mean it that way. For context, my official diagnosis is atypical cystic fibrosis. I was diagnosed a bit over 17 years ago. I had been bedridden for several months and had a hole in my left lung. Classical CF account…

Yeah, sorry, didn't mean it as a dismissal at all. Was actually trying to support your claims. Good evening.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#49

Earlier quoted context omitted.

Thank you. It's a reasonable comment. Unfortunately, in the context of multiple people being incredibly dismissive, it somewhat comes across as just another dismissal, though I sincerely believe you don't mean it that way. For context, my official diagnosis is atypical cystic fibrosis. I was diagnosed a bit over 17 years ago. I had been bedridden for several months and had a hole in my left lung. Classical CF account…

Yeah, sorry, didn't mean it as a dismissal at all. Was actually trying to support your claims. Good evening.

I realize that. I apologize for dumping on you.

Re: A bone-marrow transplant treated a patient’s leukemia – and his schizophrenia

#50

When penicillin was first used to treat syphilis, thousands of cured schizophrenics were released from mental asylums. https://www.newsweek.com/diseases-mind-133263 I've apparently submitted this article three times, the last time 18 days ago. It's never gotten traction. I have a long history of viewing mood issues and the like as somatopsychic side effects of medical issues. I tend to ask my sciency son to "Look up…

> When penicillin was first used to treat syphilis, thousands of cured schizophrenics were released from mental asylums

Syphilis itself produces psychosis and those "schizophrenics" were most likely never schizophrenics in the first place (shame on you Newsweek)

https://www.ncbi.nlm.nih.gov/pubmed/11186166 https://www.ncbi.nlm.nih.gov/pubmed/1521109

If those diet based treatments work for you then that's great but, respectfully, I think everyone should take those statements with a serious pinch of salt (no pun intended)

Edited 2x for brevity, grammar

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