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Reading comprehension is mostly about subject knowledgeActually reading comprehension is about everything _besides_ subject knowledge.
It's about the pure ability to understand something you've read -- e.g. to understand tone, intent, turns of phrase, idioms, writing styles, patterns, argument building, etc -- not about having some particular domain knowledge.
In other words if you read an article about a physics experiment but didn't understand it because you don't know what "spin", "wavefunction", or "interferometer" means in QM, then you don't have a reading comprehension problem. You just have a lack of physics knowledge.
If, inversely, you read an article about something you know very well in real life (e.g. baseball), but miss what the author tries to say, mistake the intent of some metaphor, misunderstand the argumentation, etc, then you do have a reading comprehension problem.
Of course to comprehend something you read you also need to be familiar with the thing it's talking about to. But reading comprehension is about everything else but that part -- it's about being familiar with the written word and the ways people express things in writing in themselves [1].
[1] "Fundamental skills required in efficient reading comprehension are knowing meaning of words, ability to understand meaning of a word from discourse context, ability to follow organization of passage and to identify antecedents and references in it, ability to draw inferences from a passage about its contents, ability to identify the main thought of a passage, ability to answer questions answered in a passage, ability to recognize the literary devices or propositional structures used in a passage and determine its tone, to understand the situational mood (agents, objects, temporal and spatial reference points, casual and intentional inflections, etc.) conveyed for assertions, questioning, commanding, refraining etc. and finally ability to determine writer's purpose, intent and point of view, and draw inferences about the writer"